Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Ljubomir Buturovic"'
Autor:
Ljubomir Buturovic, Hong Zheng, Benjamin Tang, Kevin Lai, Win Sen Kuan, Mark Gillett, Rahul Santram, Maryam Shojaei, Raquel Almansa, Jose Ángel Nieto, Sonsoles Muñoz, Carmen Herrero, Nikolaos Antonakos, Panayiotis Koufargyris, Marina Kontogiorgi, Georgia Damoraki, Oliver Liesenfeld, James Wacker, Uros Midic, Roland Luethy, David Rawling, Melissa Remmel, Sabrina Coyle, Yiran E. Liu, Aditya M. Rao, Denis Dermadi, Jiaying Toh, Lara Murphy Jones, Michele Donato, Purvesh Khatri, Evangelos J. Giamarellos-Bourboulis, Timothy E. Sweeney
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Predicting the severity of COVID-19 remains an unmet medical need. Our objective was to develop a blood-based host-gene-expression classifier for the severity of viral infections and validate it in independent data, including COVID-19. We de
Externí odkaz:
https://doaj.org/article/ee4e353ebc1a4a9cbf2de80046f1b3f4
Autor:
Michael B. Mayhew, Ljubomir Buturovic, Roland Luethy, Uros Midic, Andrew R. Moore, Jonasel A. Roque, Brian D. Shaller, Tola Asuni, David Rawling, Melissa Remmel, Kirindi Choi, James Wacker, Purvesh Khatri, Angela J. Rogers, Timothy E. Sweeney
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Diagnosing acute infections based on transcriptional host response shows promise, but generalizability is wanting. Here, the authors use a co-normalization framework to train a classifier to diagnose acute infections and apply it to independent data
Externí odkaz:
https://doaj.org/article/1514bf7fdf6d4f5db8c9b6afeda1ce2b
Autor:
Manjiri M. Bakre, Charusheila Ramkumar, Arun Kumar Attuluri, Chetana Basavaraj, Chandra Prakash, Ljubomir Buturovic, Lekshmi Madhav, Nirupama Naidu, Prathima R, S. P. Somashekhar, Sudeep Gupta, Dinesh Chandra Doval, Mark D. Pegram
Publikováno v:
Cancer Medicine, Vol 8, Iss 4, Pp 1755-1764 (2019)
Abstract CanAssist‐Breast (CAB) is an immunohistochemistry (IHC)‐based prognostic test for early‐stage Hormone Receptor (HR+)‐positive breast cancer patients. CAB uses a Support Vector Machine (SVM) trained algorithm which utilizes expression
Externí odkaz:
https://doaj.org/article/9e0599c8445a41efaf55c1598f1c78cc
Autor:
Arun Kumar Attuluri, Chandra Prakash V. Serkad, Aparna Gunda, Charusheila Ramkumar, Chetana Basavaraj, Ljubomir Buturovic, Lekshmi Madhav, Nirupama Naidu, Naveen Krishnamurthy, R. Prathima, Suchita Kanaldekar, Manjiri M. Bakre
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background CanAssist-Breast is an immunohistochemistry based test that predicts risk of distant recurrence in early-stage hormone receptor positive breast cancer patients within first five years of diagnosis. Immunohistochemistry gradings fo
Externí odkaz:
https://doaj.org/article/2f220efa6fd54db491fdcb096acc2418
Autor:
John E. Schneider, Jonathan Romanowsky, Philipp Schuetz, Ivana Stojanovic, Henry K. Cheng, Oliver Liesenfeld, Ljubomir Buturovic, Timothy E. Sweeney
Publikováno v:
Journal of Health Economics and Outcomes Research, Vol 7, Iss 1 (2020)
**Background:** Early identification of acute infections and sepsis remains an unmet medical need. While early detection and initiation of treatment reduces mortality, inappropriate treatment leads to adverse events and the development of antimicrobi
Externí odkaz:
https://doaj.org/article/b45f856a3f1048fdba9e5b3cd72cddac
Autor:
Charusheila Ramkumar, Ljubomir Buturovic, Sukriti Malpani, Arun Kumar Attuluri, Chetana Basavaraj, Chandra Prakash, Lekshmi Madhav, Dinesh Chandra Doval, Anurag Mehta, Manjiri M Bakre
Publikováno v:
Biomarker Insights, Vol 13 (2018)
Use of proteomic strategies to identify a risk classifier that estimates probability of distant recurrence in early-stage hormone receptor (HR)-positive breast cancer is relevant to physiological cellular function and therefore to intrinsic tumor bio
Externí odkaz:
https://doaj.org/article/9e374843199e40d28fcc6ff12281eec0
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91240 (2014)
We address the problem of assigning biological function to solved protein structures. Computational tools play a critical role in identifying potential active sites and informing screening decisions for further lab analysis. A critical parameter in t
Externí odkaz:
https://doaj.org/article/bce390ce38974c6ab2da3062393b67f4
Autor:
Noa Galtung, Eva Diehl-Wiesenecker, Dana Lehmann, Natallia Markmann, Wilma H. Bergström, James Wacker, Oliver Liesenfeld, Michael Mayhew, Ljubomir Buturovic, Roland Luethy, Timothy E. Sweeney, Rudolf Tauber, Kai Kappert, Rajan Somasundaram, Wolfgang Bauer
Publikováno v:
European Journal of Emergency Medicine. 29:357-365
mRNA-based host response signatures have been reported to improve sepsis diagnostics. Meanwhile, prognostic markers for the rapid and accurate prediction of severity in patients with suspected acute infections and sepsis remain an unmet need. IMX-SEV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65442d556c41db25dae11e313486f28
https://doi.org/10.1097/mej.0000000000000931
https://doi.org/10.1097/mej.0000000000000931
Autor:
James Wacker, Timothy E. Sweeney, Oliver Liesenfeld, Wolfgang Bauer, Rajan Somasundaram, Ljubomir Buturovic, Roland Luethy, Dana Lehmann, Kai Kappert, Noa Galtung, Henry K Cheng, Rudolf Tauber
Publikováno v:
Critical Care Medicine
Supplemental Digital Content is available in the text.
OBJECTIVES: The rapid diagnosis of acute infections and sepsis remains a serious challenge. As a result of limitations in current diagnostics, guidelines recommend early antimicrobials for s
OBJECTIVES: The rapid diagnosis of acute infections and sepsis remains a serious challenge. As a result of limitations in current diagnostics, guidelines recommend early antimicrobials for s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1afa9269ea47e1bef96aad74a2f4e43b
https://pubmed.ncbi.nlm.nih.gov/34529611
https://pubmed.ncbi.nlm.nih.gov/34529611
Autor:
Ljubomir Buturovic, Oliver Liesenfeld, Eric M. Wohlford, Timothy E. Sweeney, Florian Uhle, Yudong D He
Publikováno v:
Journal of Personalized Medicine
Volume 11
Issue 8
Journal of Personalized Medicine, Vol 11, Iss 735, p 735 (2021)
Volume 11
Issue 8
Journal of Personalized Medicine, Vol 11, Iss 735, p 735 (2021)
In response to the unmet need for timely accurate diagnosis and prognosis of acute infections and sepsis, host-immune-response-based tests are being developed to help clinicians make more informed decisions including prescribing antimicrobials, order
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6aa6d2d0fb09cd32f3e899011ad333c
https://pubmed.ncbi.nlm.nih.gov/34442377
https://pubmed.ncbi.nlm.nih.gov/34442377