Výsledky vyhledávání - "Ljubica Harhaji"

Akademický článek

3-Methyladenine prevents energy stress-induced necrotic death of melanoma cells through autophagy-independent mechanisms

Autor: Milica Kosic, Verica Paunovic, Biljana Ristic, Aleksandar Mircic, Mihajlo Bosnjak, Danijela Stevanovic, Tamara Kravic-Stevovic, Vladimir Trajkovic, Ljubica Harhaji-Trajkovic

Publikováno v: Journal of Pharmacological Sciences, Vol 147, Iss 1, Pp 156-167 (2021)

We investigated the effect of 3-methyladenine (3MA), a class III phosphatidylinositol 3-kinase (PI3K)-blocking autophagy inhibitor, on cancer cell death induced by simultaneous inhibition of glycolysis by 2-deoxyglucose (2DG) and mitochondrial respir

Externí odkaz: https://doaj.org/article/eb8d900fabeb461fb94e00420a9dca50

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Akademický článek

The Exploitation of Lysosomes in Cancer Therapy with Graphene-Based Nanomaterials

Autor: Biljana Ristic, Mihajlo Bosnjak, Maja Misirkic Marjanovic, Danijela Stevanovic, Kristina Janjetovic, Ljubica Harhaji-Trajkovic

Publikováno v: Pharmaceutics, Vol 15, Iss 7, p 1846 (2023)

Graphene-based nanomaterials (GNMs), including graphene, graphene oxide, reduced graphene oxide, and graphene quantum dots, may have direct anticancer activity or be used as nanocarriers for antitumor drugs. GNMs usually enter tumor cells by endocyto

Externí odkaz: https://doaj.org/article/185a04bb33fc43d9806f8a114411abb8

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Akademický článek

Autophagy Receptor p62 Regulates SARS-CoV-2-Induced Inflammation in COVID-19

Autor: Verica Paunovic, Ljubica Vucicevic, Maja Misirkic Marjanovic, Vladimir Perovic, Biljana Ristic, Mihajlo Bosnjak, Milos Mandic, Danijela Stevanovic, Ljubica Harhaji-Trajkovic, Jovan Lalosevic, Milos Nikolic, Branka Bonaci-Nikolic, Vladimir Trajkovic

Publikováno v: Cells, Vol 12, Iss 9, p 1282 (2023)

As autophagy can promote or inhibit inflammation, we examined autophagy-inflammation interplay in COVID-19. Autophagy markers in the blood of 19 control subjects and 26 COVID-19 patients at hospital admission and one week later were measured by ELISA

Externí odkaz: https://doaj.org/article/fc92143248cb4e51be0b73ee2d0d5c6f

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Akademický článek

Mechanisms and therapeutic significance of autophagy modulation by antipsychotic drugs

Autor: Ljubica Vucicevic, Maja Misirkic-Marjanovic, Ljubica Harhaji-Trajkovic, Nadja Maric, Vladimir Trajkovic

Publikováno v: Cell Stress, Vol 2, Iss 11, Pp 282-291 (2018)

In this review we analyze the ability of antipsychotic medications to modulate macroautophagy, a process of controlled lysosomal digestion of cellular macromolecules and organelles. We focus on its molecular mechanisms, consequences for the function/

Externí odkaz: https://doaj.org/article/65da93e103dc4cb5bb1a48827142f414

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Akademický článek

Data supporting the inability of indomethacin to induce autophagy in U251 glioma cells

Autor: Aleksandar Pantovic, Katarina Arsikin, Milica Kosic, Biljana Ristic, Vladimir Trajkovic, Ljubica Harhaji-Trajkovic

Publikováno v: Data in Brief, Vol 11, Iss C, Pp 225-230 (2017)

Autophagy, a catabolic process involving intracellular degradation of unnecessary or dysfunctional cellular components through the lysosomal machinery, could act as a prosurvival, as well as a cytotoxic mechanism (Parzych and Klionsky, 2014) [1]. Cyc

Externí odkaz: https://doaj.org/article/a26d23a87ca64a05b12974e2dfd7f79e

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Akademický článek

The protective role of AMP-activated protein kinase in alpha-synuclein neurotoxicity in vitro

Autor: Marija Dulovic, Maja Jovanovic, Maria Xilouri, Leonidas Stefanis, Ljubica Harhaji-Trajkovic, Tamara Kravic-Stevovic, Verica Paunovic, Mustafa T. Ardah, Omar M.A. El-Agnaf, Vladimir Kostic, Ivanka Markovic, Vladimir Trajkovic

Publikováno v: Neurobiology of Disease, Vol 63, Iss , Pp 1-11 (2014)

In the present study, we investigated the role of the main intracellular energy sensor, AMP-activated protein kinase (AMPK), in the in vitro neurotoxicity of α-synuclein (ASYN), one of the key culprits in the pathogenesis of Parkinson's disease. The

Externí odkaz: https://doaj.org/article/0a9614463d274d7799fd5280936268cb

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Akademický článek

Inhibition of mTOR-dependent autophagy sensitizes leukemic cells to cytarabine-induced apoptotic death.

Autor: Mihajlo Bosnjak, Biljana Ristic, Katarina Arsikin, Aleksandar Mircic, Violeta Suzin-Zivkovic, Vladimir Perovic, Andrija Bogdanovic, Verica Paunovic, Ivanka Markovic, Vladimir Bumbasirevic, Vladimir Trajkovic, Ljubica Harhaji-Trajkovic

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e94374 (2014)

The present study investigated the role of autophagy, a cellular self-digestion process, in the cytotoxicity of antileukemic drug cytarabine towards human leukemic cell lines (REH, HL-60, MOLT-4) and peripheral blood mononuclear cells from leukemic p

Externí odkaz: https://doaj.org/article/ed2a0c99417743179a0e9eeb16e6ca6c

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