Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ljiljana Zuvela-Jelaska"'
Autor:
Steven J. Taylor, Asitha Abeywardane, Shuang Liang, Zhaoming Xiong, John R. Proudfoot, Bennett Sandy Farmer, Donghong A. Gao, Alexander Heim-Riether, Lana Louise Smith-Keenan, Ingo Muegge, Yang Yu, Qiang Zhang, Donald Souza, Mark Panzenbeck, Daniel Goldberg, Melissa Hill-Drzewi, Mariana Margarit, Brandon Collins, John Xiang Li, Ljiljana Zuvela-Jelaska, Jun Li, Neil A. Farrow
Publikováno v:
ACS Omega, Vol 6, Iss 29, Pp 18635-18650 (2021)
Externí odkaz:
https://doaj.org/article/28925716e0524cb7af79c7a4126b692b
Autor:
Bishi Fu, Mengmeng Zhao, Lingyan Wang, Girish Patil, Jennifer A. Smith, Ignacio J. Juncadella, Ljiljana Zuvela-Jelaska, Martin E. Dorf, Shitao Li
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Interferon regulatory factor 5 (IRF5) is a key transcription factor of innate immunity, which plays an important role in host restriction to viral infection and inflammation. Genome-wide association studies have implied the association of IR
Externí odkaz:
https://doaj.org/article/3b52515862064e31851be11761ce05b9
Autor:
Jun Li, Frank H. Büttner, Martin Winter, Annekatrin Heimann, Daniel Bischoff, Roman P. Simon, Andreas H. Luippold, Wolfgang Reindl, Robert Ries, Tom Bretschneider, Gisela Schnapp, Ljiljana Zuvela-Jelaska, Carola Kleiner
Publikováno v:
SLAS Discovery. 25:372-383
Comprehensive and unbiased detection methods are a prerequisite for high-throughput screening (HTS) campaigns within drug discovery research. Label-free matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d4090c1e13cb42ec8c31702c9b546e
https://doi.org/10.1177/2472555219880185
https://doi.org/10.1177/2472555219880185
Autor:
John Xiang Li, Steven John Taylor, Mariana Margarit, Jun Li, Yu Yang, Qiang Zhang, Ingo Muegge, Melissa Hill-Drzewi, Alexander Heim-Riether, Mark Panzenbeck, Asitha Abeywardane, Zhaoming Xiong, Daniel R. Goldberg, Bennett Sandy Farmer, Gao Donghong A, Ljiljana Zuvela-Jelaska, John R. Proudfoot, Shuang Liang, Donald Souza, Lana Louise Smith-Keenan, Neil A. Farrow, Brandon Collins
Publikováno v:
ACS Omega
ACS Omega, Vol 6, Iss 29, Pp 18635-18650 (2021)
ACS Omega, Vol 6, Iss 29, Pp 18635-18650 (2021)
Here, we described the design, by fragment merging and multiparameter optimization, of selective MMP-13 inhibitors that display an appropriate balance of potency and physicochemical properties to qualify as tool compounds suitable for in vivo testing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f527696acc72281bab3399c1433275
https://pubmed.ncbi.nlm.nih.gov/34337203
https://pubmed.ncbi.nlm.nih.gov/34337203
Autor:
Martin E. Dorf, Shitao Li, Bishi Fu, Lingyan Wang, Girish Patil, Ljiljana Zuvela-Jelaska, Jennifer A. Smith, Ignacio J. Juncadella, Mengmeng Zhao
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Interferon regulatory factor 5 (IRF5) is a key transcription factor of innate immunity, which plays an important role in host restriction to viral infection and inflammation. Genome-wide association studies have implied the association of IRF5 with s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e83cbe50e986af59da06079f3b749b
https://doi.org/10.1038/s41598-017-02857-z
https://doi.org/10.1038/s41598-017-02857-z
Autor:
Usha R. Patel, Richard M. Nelson, Gerald Nabozny, Christian Harcken, Zhidong Chen, Ljiljana Zuvela-Jelaska, Donald Souza, Todd Bosanac, Alison Kukulka, Mita Patel, Thomas Wai-Ho Lee, Doris Riether, Mark Stephen Ralph, David S. Thomson, Tazmeen Fadra-Khan, Yancey David Ward, Hossein Razavi, Pingrong Liu
Publikováno v:
ACS Medicinal Chemistry Letters. 5:1318-1323
A series of nonsteroidal "dissociated" glucocorticoid receptor agonists was optimized for drug-like properties such as cytochrome P450 inhibition, metabolic stability, aqueous solubility, and hERG ion channel inhibition. This effort culminated in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a0b3a664e8a09670118611ff93aeba
https://doi.org/10.1021/ml500387y
https://doi.org/10.1021/ml500387y
Autor:
Michel J. Emmanuel, Jonathan T. Reeves, Christian Harcken, Raj Betageri, Richard M. Nelson, Jörg Bentzien, Gerald Nabozny, Alison Kukulka, Ljiljana Zuvela-Jelaska, Tazmeen N. Fadra, Roger M. Dinallo, Donald Souza, Doris Riether, Mark Stephen Ralph, David S. Thomson, Angela Berry, Daniel Kuzmich, Pingrong Liu
Publikováno v:
Journal of Medicinal Chemistry. 57:1583-1598
Synthesis and structure-activity relationship (SAR) of a series of nonsteroidal glucocorticoid receptor (GR) agonists are described. These compounds contain "diazaindole" moieties and display different transcriptional regulatory profiles in vitro and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e6fcde7b564a7f668cbef134972ed1
https://doi.org/10.1021/jm4019178
https://doi.org/10.1021/jm4019178
Autor:
Edward Y. Skolnik, Jun Li, Jonathan M. Backer, Xinjiang Cai, Ljiljana Zuvela-Jelaska, Rachel S. Salamon, Zhai Li, Yi Sun, Shekhar Srivastava, Haiyan Wu
Publikováno v:
Proceedings of the National Academy of Sciences. 108:20072-20077
The K + channel KCa3.1 is required for Ca 2+ influx and the subsequent activation of CD4 T cells. The class II phosphatidylinositol 3 kinase C2β (PI3KC2β) is activated by the T-cell receptor (TCR) and is critical for KCa3.1 channel activation. Trip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c840d5c9c8c21a611c358d255d9ab0b3
https://doi.org/10.1073/pnas.1111233109
https://doi.org/10.1073/pnas.1111233109
Autor:
Hidenori Takahashi, Younes Bekkali, Alison J. Capolino, Thomas Gilmore, Susan E. Goldrick, Richard M. Nelson, Donna Terenzio, Ji Wang, Ljiljana Zuvela-Jelaska, John Proudfoot, Gerald Nabozny, David Thomson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:1549-1552
We report the discovery of a novel class of glucocorticoid receptor (GR) ligands based on 1,2-dihydroquinoline molecular scaffold. The compounds exhibit good GR binding affinity and selectivity profile against other nuclear hormone receptors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bbdc57440c4c342f5801e2dff50dff5
https://doi.org/10.1016/j.bmcl.2005.12.043
https://doi.org/10.1016/j.bmcl.2005.12.043
Autor:
Donald Souza, Mark Panzenbeck, Jörg Bentzien, Tazmeen Fadra-Khan, Carol A. Torcellini, Roger M. Dinallo, Christian Harcken, Hossein Razavi, Alison Kukulka, Gerald Nabozny, Ljiljana Zuvela-Jelaska, David S. Thomson, Richard M. Nelson, Josephine Pelletier, Edward Pack, Doris Riether, John R. Proudfoot
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(8)
Synthesis and structure-activity relationship (SAR) of a series of alkyl and cycloalkyl containing non-steroidal dissociated glucocorticoid receptor (GR) agonists is reported. This series of compounds was identified as part of an effort to replace th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a3d38ce00c671a4e81b5135c46af55
https://pubmed.ncbi.nlm.nih.gov/24656565
https://pubmed.ncbi.nlm.nih.gov/24656565