Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lizzy Wanka"'
Publikováno v:
Biological Chemistry. 403:133-149
The internalization of G protein-coupled receptors (GPCRs) is an important mechanism regulating the signal strength and limiting the opportunity of receptor activation. Based on the importance of GPCRs, the detailed knowledge about the regulation of
Publikováno v:
Cellular and Molecular Life Sciences. 77:4675-4691
Functionally selective ligands to address specific cellular responses downstream of G protein-coupled receptors (GPCR) open up new possibilities for therapeutics. We designed and characterized novel subtype- and pathway-selective ligands. Substitutio
Autor:
Uta Jappe, Lizzy Wanka
Publikováno v:
Allergy. 76:1265-1267
Publikováno v:
Cellular Signalling. 50:58-71
GPCR internalization, which is induced by arrestin recruitment, is an important mechanism for the regulation of signaling and receptor quantity at the cell surface. In this study, differences in the mechanism of arrestin-3 (arr-3) recruitment to the
Autor:
Caroline Hempel, Lizzy Wanka, Annette G. Beck-Sickinger, Mario Schubert, Anette Kaiser, Heidi E. Hamm
Publikováno v:
Molecular Pharmacology. 93:387-401
Ligand binding and pathway-specific activation of G protein–coupled receptors is currently being studied with great effort. Individual answers may depend on the nature of the ligands and the effector pathway. Recently, we have presented a detailed
Autor:
Karin Mörl, Kerstin Burkert, Stefanie Babilon, Vsevolod V. Gurevich, Lizzy Wanka, Annette G. Beck-Sickinger
Publikováno v:
Cellular Signalling. 29:233-239
The human neuropeptide Y4 receptor is a rhodopsin-like G protein-coupled receptor (GPCR), which contributes to anorexigenic signals. Thus, this receptor is a highly interesting target for metabolic diseases. As GPCR internalization and trafficking af
Publikováno v:
Cellular and molecular life sciences : CMLS. 77(22)
Functionally selective ligands to address specific cellular responses downstream of G protein-coupled receptors (GPCR) open up new possibilities for therapeutics. We designed and characterized novel subtype- and pathway-selective ligands. Substitutio
Publikováno v:
Cellular signalling. 50
GPCR internalization, which is induced by arrestin recruitment, is an important mechanism for the regulation of signaling and receptor quantity at the cell surface. In this study, differences in the mechanism of arrestin-3 (arr-3) recruitment to the
Autor:
Anette, Kaiser, Caroline, Hempel, Lizzy, Wanka, Mario, Schubert, Heidi E, Hamm, Annette G, Beck-Sickinger
Publikováno v:
Molecular pharmacology. 93(4)
Ligand binding and pathway-specific activation of G protein-coupled receptors is currently being studied with great effort. Individual answers may depend on the nature of the ligands and the effector pathway. Recently, we have presented a detailed mo
Autor:
Lizzy Wanka, Kathrin Bellmann-Sickert, Veronika Mäde, Annette G. Beck-Sickinger, Helen M. Cox, Luis E. Gimenez, Stefanie Babilon, Vsevolod V. Gurevich, Navjeet Jolly, Karin Mörl
Publikováno v:
Angewandte Chemie International Edition. 53:10067-10071
Although G protein-coupled receptors (GPCRs) are targeted by more clinically used drugs than any other type of protein, their ligand development is particularly challenging. Humans have four neuropeptide Y receptors: hY1R and hY5R are orexigenic, whi