Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lizzette Pérez Pérez"'
Autor:
Meaghan Flagg, Kerry Goldin, Lizzette Pérez-Pérez, Manmeet Singh, Brandi N. Williamson, Nathanael Pruett, Chuong D. Hoang, Emmie de Wit
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 2 (2023)
There is tremendous heterogeneity in the severity of COVID-19 disease in the human population, and the mechanisms governing the development of severe disease remain incompletely understood. The emergence of SARS-CoV-2 variants of concern (VOC) Delta
Externí odkaz:
https://doaj.org/article/ec540c177e954033983095d97fb37a3b
Autor:
Emily Speranza, Jyothi N Purushotham, Julia R Port, Benjamin Schwarz, Meaghan Flagg, Brandi N Williamson, Friederike Feldmann, Manmeet Singh, Lizzette Pérez-Pérez, Gail L Sturdevant, Lydia M Roberts, Aaron Carmody, Jonathan E Schulz, Neeltje van Doremalen, Atsushi Okumura, Jamie Lovaglio, Patrick W Hanley, Carl Shaia, Ronald N Germain, Sonja M Best, Vincent J Munster, Catharine M Bosio, Emmie de Wit
Publikováno v:
Life science alliance. 5(4)
Advanced age is a key predictor of severe COVID-19. To gain insight into this relationship, we used the rhesus macaque model of SARS-CoV-2 infection. Eight older and eight younger macaques were inoculated with SARS-CoV-2. Animals were evaluated using
Autor:
Jyothi N. Purushotham, Julia R Port, Manmeet Singh, Lydia M. Roberts, Jonathan E Schulz, Patrick W. Hanley, Catharine M. Bosio, Atsushi Okumura, Benjamin Schwarz, Gail L. Sturdevant, Brandi N. Williamson, Sonja M. Best, Lizzette Pérez-Pérez, Jamie Lovaglio, Friederike Feldmann, Ronald N. Germain, Emily Speranza, Aaron B. Carmody, Carl Shaia, Emmie de Wit, Vincent J. Munster, Meaghan Flagg, Neeltje van Doremalen
Advanced age is a key predictor of severe COVID-19. To gain insight into this relationship, particularly with respect to immune responses, we utilized the rhesus macaque model of SARS-CoV-2 infection. Two cohorts of eight older (16-23 years) and eigh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::726dae533f9e34fc120335482920f1bb
https://doi.org/10.1101/2021.09.08.459430
https://doi.org/10.1101/2021.09.08.459430
Autor:
Patrick W. Hanley, Myndi G. Holbrook, Neeltje van Doremalen, Emmie de Wit, Greg Saturday, Brian J. Smith, Vincent J. Munster, Brandi N. Williamson, Craig Martens, Jamie Lovaglio, Beniah Brumbaugh, Atsushi Okumura, Danielle R. Adney, Claude Kwe Yinda, Meaghan Flagg, Sarah L. Anzick, Lizzette Pérez-Pérez, Jonathan E Schulz, Manmeet Singh, Friederike Feldmann
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
Science Advances
article-version (status) pre
article-version (number) 1
Science Advances
Description
SARS-CoV-2 variants of concern B.1.1.7 and B.1.351 do not cause more severe disease in rhesus macaques.
The emergence of several SARS-CoV-2 variants has caused global concerns about increased transmissibility, increased pathogen
SARS-CoV-2 variants of concern B.1.1.7 and B.1.351 do not cause more severe disease in rhesus macaques.
The emergence of several SARS-CoV-2 variants has caused global concerns about increased transmissibility, increased pathogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c411b91062bc2d7de7e25d391e056104
https://doi.org/10.1101/2021.05.07.443115
https://doi.org/10.1101/2021.05.07.443115
Autor:
Yonghua Li, David Kaufman, Peter Meyn, Nancy Amoroso, Huilin Li, Clea Barnett, Stephen T. Yeung, Bo Shopsin, Laura Evans, Luis Angel, Imran Sulaiman, Jan Bakker, Ann Marie Schmidt, Deepak Pradhan, Christian V. Forst, Ralf Duerr, Timothy M. Uyeki, Kenneth A. Stapleford, Sara A Thannickal, J. Carpenito, Vikramjit Mukherjee, Jose C. Clemente, Anthony Lubinsky, Michael D. Weiden, Guomiao Shen, Shari B. Brosnahan, Kun Ji, Lizzette Pérez-Pérez, R. Schluger, Daniel H. Sterman, Adriana Hegu, Stephanie Banakis, Xiuxiu Liu, Chang Wang, Bin Zhang, Chan Wang, Leopoldo N. Segal, Benjamin G. Wu, Destiny Collazo, Jun-Chieh J. Tsay, Radu Postelnicu, Matthew Chung, George Jour, Kamal M. Khanna, Elodie Ghedin, Emmie de Wit, Kelsey Krolikowski, Ludovic Desvignes, Samaan Rafeq, Anthony Labarbiera, Akiko Koide, Shohei Koide
Publikováno v:
Research Square
article-version (status) pre
article-version (number) 1
medRxiv
Nat Microbiol
article-version (status) pre
article-version (number) 1
medRxiv
Nat Microbiol
Mortality among patients with COVID-19 and respiratory failure is high and there are no known lower airway biomarkers that predict clinical outcome. We investigated whether bacterial respiratory infections and viral load were associated with poor cli
Autor:
Heinz Feldmann, Atsushi Okumura, Kimberly Meade-White, Brandi N. Williamson, Friederike Feldmann, Brian J. Smith, Sonja M. Best, Lizzette Pérez Pérez, Jamie Lovaglio, Emmie de Wit, Gail L. Sturdevant, Vincent J. Munster, Carl Shaia, Emily Speranza, Craig Martens
Publikováno v:
Science Translational Medicine
Single-cell RNA sequencing of lungs of SARS-CoV-2–infected African green monkeys reveals virus replication and host response dynamics in vivo.
A dynamic response to SARS-CoV-2 While a number of animal models for SARS-CoV-2 have been developed,
A dynamic response to SARS-CoV-2 While a number of animal models for SARS-CoV-2 have been developed,
Autor:
Sarah C. Gilbert, Dana P. Scott, Dan Long, Patrick W. Hanley, Neeltje van Doremalen, Daniel B. Wright, Nick J. Edwards, Lizzette Pérez-Pérez, Ciaran Gilbride, Amy Flaxman, Louisa Rose, Kimberly Meade-White, Rebecca Rosenke, Brandi N. Williamson, Vincent J. Munster, Friederike Feldmann, Greg Saturday, Claire Powers, Myndi G. Holbrook, Victoria A. Avanzato, Elizabeth R. Allen, Hannah Sharpe, Jyothi N. Purushotham, Jamie Lovaglio, Marta Ulaszewska, Alexandra J. Spencer, Teresa Lambe, Susan J. Morris, Sandra Belij-Rammerstorfer, Emmie de Wit, Atsushi Okumura, Trenton Bushmaker, Alka Ishwarbhai, Cameron Bissett, Reshma Kailath, Julia R Port, Jonathan E Schulz
Publikováno v:
Nature
Autor:
Brandi N. Williamson, Lizzette Pérez-Pérez, Benjamin Schwarz, Friederike Feldmann, Myndi G. Holbrook, Manmeet Singh, Diane S. Lye, Darius Babusis, Raju Subramanian, Elaine Haddock, Atsushi Okumura, Patrick W. Hanley, Jamie Lovaglio, Catharine M. Bosio, Danielle P. Porter, Tomas Cihlar, Richard L. Mackman, Greg Saturday, Emmie de Wit
Publikováno v:
Antiviral Research
The utility of remdesivir treatment in COVID-19 patients is currently limited by the necessity to administer this antiviral intravenously, which has generally limited its use to hospitalized patients. Here, we tested a novel, subcutaneous formulation
Autor:
Atsushi Okumura, Emmie de Wit, Carl Shaia, Heinz Feldmann, Brandi N. Williamson, Craig Martens, Gail L. Sturdevant, Kimberly Meade-White, Vincent J. Munster, Lizzette Pérez-Pérez, Emily Speranza, Sonja M. Best, Brian J. Smith, Friederike Feldmann, Jamie Lovaglio
Detailed knowledge about the dynamics of SARS-CoV-2 infection is important for unraveling the viral and host factors that contribute to COVID-19 pathogenesis. Old-World nonhuman primates recapitulate mild-moderate COVID-19 cases, thereby serving as i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40875d1efaa2a3b90e023a785325f893
https://doi.org/10.1101/2020.08.20.258087
https://doi.org/10.1101/2020.08.20.258087
Autor:
Patrick W. Hanley, Alexandra J. Spencer, Atsushi Okumura, Lizzette Pérez-Pérez, Cameron Bissett, Jonathan E Schulz, Vincent J. Munster, Elizabeth R. Allen, Neeltje van Doremalen, Jyothi N. Purushotham, Sandra Belij-Rammerstorfer, Brandi N. Williamson, Hannah Sharpe, Marta Ulaszewska, Jamie Lovaglio, Ciaran Gilbride, Victoria A. Avanzato, Claire Powers, Amy Flaxman, Dana P. Scott, Julia R Port, Greg Saturday, Trenton Bushmaker, Alka Ishwarbhai, Sarah C. Gilbert, Kimberly Meade-White, Rebecca Rosenke, Daniel B. Wright, Myndi G. Holbrook, Nick J. Edwards, Emmie de Wit, Dan Long, Susan J. Morris, Louisa Rose, Friederike Feldmann, Reshma Kailath, Teresa Lambe
Publikováno v:
bioRxiv
Nature
Nature
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 20191,2 and is responsible for the coronavirus disease 2019 (COVID-19) pandemic3. Vaccines are an essential countermeasure and are urgently needed to control the pandemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59be2da9b9eee23ecde3d871142468c5
https://europepmc.org/articles/PMC7241103/
https://europepmc.org/articles/PMC7241103/