Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Lizhou ZHANG"'
Autor:
Yuka Otsuka, Lizhou Zhang, Huihui Mou, Justin Shumate, Claire E. Kitzmiller, Louis Scampavia, Thomas D. Bannister, Michael Farzan, Hyeryun Choe, Timothy P. Spicer
Publikováno v:
SLAS Discovery, Vol 29, Iss 6, Pp 100178- (2024)
Emerging highly pathogenic viruses can pose profound impacts on global health, the economy, and society. To meet that challenge, the National Institute of Allergy and Infectious Diseases (NIAID) established nine Antiviral Drug Discovery (AViDD) cente
Externí odkaz:
https://doaj.org/article/11c7a571d55c43108e85b47fce35be0e
Publikováno v:
Zhongguo dizhi zaihai yu fangzhi xuebao, Vol 34, Iss 5, Pp 97-106 (2023)
Dangerous rock disaster is prevalent geological hazard in southwest China. Under the influence of gravity, dangerous rock masses can easily trigger rockfalls, posing a significant threat to infrastructure such as roads, bridges, and railways. Therefo
Externí odkaz:
https://doaj.org/article/e9d1a18512d940ef8eeb7543ca799fbf
Autor:
Lizhou Zhang, Kunal R. More, Amrita Ojha, Cody B. Jackson, Brian D. Quinlan, Hao Li, Wenhui He, Michael Farzan, Norbert Pardi, Hyeryun Choe
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract During the COVID-19 pandemic, Pfizer-BioNTech and Moderna successfully developed nucleoside-modified mRNA lipid nanoparticle (LNP) vaccines. SARS-CoV-2 spike protein expressed by those vaccines are identical in amino acid sequence, but sever
Externí odkaz:
https://doaj.org/article/7b70659bd0904a95a8cbe3fb1aab2982
Autor:
Lizhou Zhang1,2,3 lizhou.zhang@childrens.harvard.edu, Kitzmiller, Claire E.1, Richard, Audrey S.3, Popli, Sonam3, Hyeryun Choe1,2,3 hyeryun.choe@childrens.harvard.edu
Publikováno v:
Journal of Virology. Nov2024, Vol. 98 Issue 11, p1-22. 22p.
Autor:
Lizhou Zhang, Cody B. Jackson, Huihui Mou, Amrita Ojha, Haiyong Peng, Brian D. Quinlan, Erumbi S. Rangarajan, Andi Pan, Abigail Vanderheiden, Mehul S. Suthar, Wenhui Li, Tina Izard, Christoph Rader, Michael Farzan, Hyeryun Choe
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
SARS-CoV-2 variants with spike (S)-protein D614G mutations currently predominate globally. Here, Zhang et al. hypothesize that D614G variant may increase infectivity by increasing S protein abundance on the virion since pseudoviruses carrying S-G614
Externí odkaz:
https://doaj.org/article/5ab81391dfd1486295e3c90c83762edb
Autor:
Lizhou Zhang, Tippawan Liabsuetrakul
Publikováno v:
Environmental Research Communications, Vol 5, Iss 11, p 115011 (2023)
Waste incineration is becoming the dominant method of waste disposal globally, including in China. Local residents are concerned about the potential negative impacts of waste incineration plants (WIPs) on their environment and health. This study aime
Externí odkaz:
https://doaj.org/article/cf326038af704478a7a9ff4c384d5b34
An Engineered Receptor-Binding Domain Improves the Immunogenicity of Multivalent SARS-CoV-2 Vaccines
Autor:
Yan Guo, Wenhui He, Huihui Mou, Lizhou Zhang, Jing Chang, Shoujiao Peng, Amrita Ojha, Rubens Tavora, Mark S. Parcells, Guangxiang Luo, Wenhui Li, Guocai Zhong, Hyeryun Choe, Michael Farzan, Brian D. Quinlan
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
All available vaccines for coronavirus disease 2019 (COVID-19) express or deliver the full-length SARS-CoV-2 spike (S) protein. We show that this antigen is not optimal, consistent with observations that the vast majority of the neutralizing response
Externí odkaz:
https://doaj.org/article/6183610d6fb446c1b899921bc6de5b56
Autor:
Huihui Mou, Brian D Quinlan, Haiyong Peng, Guanqun Liu, Yan Guo, Shoujiao Peng, Lizhou Zhang, Meredith E Davis-Gardner, Matthew R Gardner, Gogce Crynen, Lindsey B DeVaux, Zhi Xiang Voo, Charles C Bailey, Michael D Alpert, Christoph Rader, Michaela U Gack, Hyeryun Choe, Michael Farzan
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009501 (2021)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein mediates infection of cells expressing angiotensin-converting enzyme 2 (ACE2). ACE2 is also the viral receptor of SARS-CoV (SARS-CoV-1), a related coronavirus that eme
Externí odkaz:
https://doaj.org/article/98e83cef2acb4c9d893d3ecb82c4b632
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009212 (2021)
Hydroxychloroquine, used to treat malaria and some autoimmune disorders, potently inhibits viral infection of SARS coronavirus (SARS-CoV-1) and SARS-CoV-2 in cell-culture studies. However, human clinical trials of hydroxychloroquine failed to establi
Externí odkaz:
https://doaj.org/article/c0eaebee92c84c4aa32b8319b2969a3a
Autor:
Lizhou Zhang, Nancy Hom, Amrita Ojha, Klaus N. Lovendahl, Huihui Mou, Kelly K. Lee, Hyeryun Choe
Publikováno v:
Journal of Virology. 97
Various forms of PVs have been used as tools to evaluate vaccine efficacy and study virus entry steps. When PV infectivity is inherently low, such as that of SARS-CoV-2, a CT-truncated version of the viral entry glycoprotein is widely used to enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd7ce398304e974669b9a423ec581e67
https://doi.org/10.1128/jvi.01650-22
https://doi.org/10.1128/jvi.01650-22