Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Lizhe Zhu"'
Autor:
Fang Ye, Xin Pan, Zhiyi Zhang, Xufu Xiang, Xinyu Li, Binghao Zhang, Peiruo Ning, Aijun Liu, Qinggong Wang, Kaizheng Gong, Jiancheng Li, Lizhe Zhu, Chungen Qian, Geng Chen, Yang Du
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114895- (2024)
Summary: Hydroxycarboxylic acid receptor 3 (HCAR3), a class A G-protein-coupled receptor, is an important cellular energy metabolism sensor with a key role in the regulation of lipolysis in humans. HCAR3 is deeply involved in many physiological proce
Externí odkaz:
https://doaj.org/article/a2ebab9f3ae24ce5a8734c1f30ab6ece
Autor:
Aijun Liu, Yezhou Liu, Geng Chen, Wenping Lyu, Fang Ye, Junlin Wang, Qiwen Liao, Lizhe Zhu, Yang Du, Richard D Ye
Publikováno v:
PLoS Biology, Vol 22, Iss 10, p e3002838 (2024)
Chemerin is an adipokine with chemotactic activity to a subset of leukocytes. Chemerin binds to 3 G protein-coupled receptors, including chemokine-like receptor 1 (CMKLR1), G protein-coupled receptor 1 (GPR1), and C-C chemokine receptor-like 2 (CCRL2
Externí odkaz:
https://doaj.org/article/7ff033937a9143a7a23d76e053593b98
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114578- (2024)
Summary: CXCR4 binding of its endogenous agonist CXCL12 leads to diverse functions, including bone marrow retention of hematopoietic progenitors and cancer metastasis. However, the structure of the CXCL12-bound CXCR4 remains unresolved despite availa
Externí odkaz:
https://doaj.org/article/ee8e99c7eb7d414da0ba9e21a6f5036e
Autor:
Jinchu Liu, Lizhe Zhu
Publikováno v:
Molecules, Vol 29, Iss 21, p 5036 (2024)
CRISPR-Cas12e is a recently identified gene-editing tool mainly known because its relatively small size benefits cell delivery. Drastically different from Cas9, it creates a blunt-end double-strand breakage of the DNA via two cleavage sites; Cas12e p
Externí odkaz:
https://doaj.org/article/e51a8fa0e6d34c30ad333a81752b5511
Autor:
Xin Pan, Fang Ye, Peiruo Ning, Zhiyi Zhang, Xinyu Li, Binghao Zhang, Qian Wang, Geng Chen, Wei Gao, Chen Qiu, Zhangsong Wu, Jiancheng Li, Lizhe Zhu, Jiang Xia, Kaizheng Gong, Yang Du
Publikováno v:
Cell Discovery, Vol 9, Iss 1, Pp 1-17 (2023)
Abstract Hydroxycarboxylic acid receptor 2 (HCAR2) belongs to the family of class A G protein-coupled receptors with key roles in regulating lipolysis and free fatty acid formation in humans. It is deeply involved in many pathophysiological processes
Externí odkaz:
https://doaj.org/article/8c6f33326a9245ae978c5009f4185e6c
Autor:
Geng Chen, Xiankun Wang, Qiwen Liao, Yunjun Ge, Haizhan Jiao, Qiang Chen, Yezhou Liu, Wenping Lyu, Lizhe Zhu, Gydo C. P. van Zundert, Michael J. Robertson, Georgios Skiniotis, Yang Du, Hongli Hu, Richard D. Ye
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Detection of invading bacteria is key to immunity. Here, the authors report cryo-electron microscopy structures of agonist-bound formyl peptide receptor 1 (FPR1), that reveal structural basis for recognition of bacteria-derived formyl peptides.
Externí odkaz:
https://doaj.org/article/213ab71046034930b5702d46eba98f44
Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-13 (2022)
Abstract Cancer stem cells (CSCs) are regarded as the root of tumor recurrence and distant metastasis, as well as the major cause of resistance to conventional cancer therapies. Elucidating the mechanism of regulating CSCs is of great significance fo
Externí odkaz:
https://doaj.org/article/c3a9a7dc89824a98b94638bfaa38ca54
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Lizhe Zhu et al. use a quasi Markov State Model built from extensive molecular dynamics simulations to elucidate the dynamics of RISC-mRNA interactions. Their results provide further insight on how a target nucleotide is positioned before recognition
Externí odkaz:
https://doaj.org/article/f9b08be56b81469197c788250c9a00d7
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundTumors are characterized by extracellular matrix (ECM) remodeling and stiffening. The ECM has been recognized as an important determinant of breast cancer progression and prognosis. Recent studies have revealed a strong link between ECM rem
Externí odkaz:
https://doaj.org/article/6b605dce484540c6b8df011d6bb6a385
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Background: In the absence of targeted therapy or clear clinically relevant biomarkers, neoadjuvant chemotherapy (NAC) is still the standard neoadjuvant systemic therapy for breast cancer. Among the many biomarkers predicting the efficacy of NAC, imm
Externí odkaz:
https://doaj.org/article/057a2567332548a0b9fcf3b5cd30b2b4