Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Lizhao Feng"'
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108037- (2023)
Summary: Myelin defects cause a collection of myelin disorders in the brain. The lack of human models has limited us from better understanding pathological mechanisms of myelin diseases. While human induced pluripotent stem cell (hiPSC)-derived spher
Externí odkaz:
https://doaj.org/article/6bd58f4442264623a67d312af92d735e
Autor:
Qi Cui, Arjit Vijey Jeyachandran, Gustavo Garcia jr., Chao Qin, Yu Zhou, Mingzi Zhang, Cheng Wang, Guihua Sun, Wei Liu, Tao Zhou, Lizhao Feng, Chance Palmer, Zhuo Li, Adam Aziz, Brigitte N. Gomperts, Pinghui Feng, Vaithilingaraja Arumugaswami, Yanhong Shi
Publikováno v:
MedComm, Vol 4, Iss 5, Pp n/a-n/a (2023)
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the causal agent for coronavirus disease 2019 (COVID‐19). Although vaccines have helped to prevent uncontrolled viral spreading, our understanding of the fundamental biolo
Externí odkaz:
https://doaj.org/article/81c88b3fb37e42ad884dc34e3347c863
Autor:
Lizhao Feng, Jianfei Chao, Peng Ye, Qui Luong, Guoqiang Sun, Wei Liu, Qi Cui, Sergio Flores, Natasha Jackson, Afm Nazmul Hoque Shayento, Guihua Sun, Zhenqing Liu, Weidong Hu, Yanhong Shi
Publikováno v:
Advanced Science, Vol 10, Iss 23, Pp n/a-n/a (2023)
Abstract Demyelinating disorders are among the most common and debilitating diseases in neurology. Canavan disease (CD) is a lethal demyelinating disease caused by mutation of the aspartoacylase (ASPA) gene, which leads to the accumulation of its sub
Externí odkaz:
https://doaj.org/article/09dd6e46f2554eef892a2a30ee48afbe
Autor:
Zhenqing Liu, Jianfei Chao, Cheng Wang, Guihua Sun, Daniel Roeth, Wei Liu, Xianwei Chen, Li Li, E Tian, Lizhao Feng, Hayk Davtyan, Mathew Blurton-Jones, Markus Kalkum, Yanhong Shi
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112841- (2023)
Summary: The C allele of rs11136000 variant in the clusterin (CLU) gene represents the third strongest known genetic risk factor for late-onset Alzheimer’s disease. However, whether this single-nucleotide polymorphism (SNP) is functional and what t
Externí odkaz:
https://doaj.org/article/77cf8d20e7704cc4ab9715b8179a709d
Autor:
Jianfei Chao, Lizhao Feng, Peng Ye, Xianwei Chen, Qi Cui, Guihua Sun, Tao Zhou, E Tian, Wendong Li, Weidong Hu, Arthur D. Riggs, Reuben Matalon, Yanhong Shi
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104391- (2022)
Summary: Canavan disease (CD) is a devastating neurological disease that lacks effective therapy. Because CD is caused by mutations of the aspartoacylase (ASPA) gene, we introduced the wild-type (WT) ASPA gene into patient iPSCs through lentiviral tr
Externí odkaz:
https://doaj.org/article/ec108dc0d5d644b9b0f6d2a356457de6
Autor:
Qian Chen, Wenqiang Zhang, Hao Ran, Lizhao Feng, Hao Yan, Xinyi Mu, Yingying Han, Wei Liu, Guoliang Xia, Chao Wang
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111423 (2014)
In mammals, gonadotropins stimulate oocyte maturation via the epidermal growth factor (EGF) network, and the protein kinase C (PKC) signaling pathway mediates this process. Tumor necrosis factor-α converting enzyme (TACE) is an important protein res
Externí odkaz:
https://doaj.org/article/caecacb4dd2a415e9ff73a3fae26b10b
Publikováno v:
Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering. 236:825-841
The performance of the model-based controller is always affected by the uncertainty and nonlinearity of the model parameters in the vehicle path tracking process. To address this issue, a novel path tracking controller based on model-free adaptive dy
Autor:
Jianfei Chao, Guihua Sun, Reuben Matalon, Edward David Meza, David Hsu, Joseph D. Gold, E Tian, Li Li, Jeremy Klein, Lizhao Feng, Yanhong Shi, Lucy Ghoda, Mi Zhang, Yue Qin, Yonglun Luo, Xianwei Chen, Wendong Li, Tao Zhou, Peng Ye, Weidong Hu, Gerardo Felix, Steven A. Goldman, Wei Dang, Qi Cui
Publikováno v:
Feng, L, Chao, J, Tian, E, Li, L, Ye, P, Zhang, M, Chen, X, Cui, Q, Sun, G, Zhou, T, Felix, G, Qin, Y, Li, W, Meza, E D, Klein, J, Ghoda, L, Hu, W, Luo, Y, Dang, W, Hsu, D, Gold, J, Goldman, S A, Matalon, R & Shi, Y 2020, ' Cell-Based Therapy for Canavan Disease Using Human iPSC-Derived NPCs and OPCs ', Advanced Science, vol. 7, no. 23, 2002155 . https://doi.org/10.1002/advs.202002155
Advanced Science
Advanced Science
Canavan disease (CD) is a fatal leukodystrophy caused by mutation of the aspartoacylase (ASPA) gene, which leads to deficiency in ASPA activity, accumulation of the substrate N‐acetyl‐L‐aspartate (NAA), demyelination, and spongy degeneration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb829c0a831a1c36593358fc5523866
https://curis.ku.dk/portal/da/publications/cellbased-therapy-for-canavan-disease-using-human-ipscderived-npcs-and-opcs(cb32e146-164e-470e-a92f-34769f863b7f).html
https://curis.ku.dk/portal/da/publications/cellbased-therapy-for-canavan-disease-using-human-ipscderived-npcs-and-opcs(cb32e146-164e-470e-a92f-34769f863b7f).html
Autor:
Meina He, Bingying Liu, Jiaqi Zhou, Chao Wang, Tuo Zhang, Huarong Wang, Guoliang Xia, Zhen Teng, Lizhao Feng, Qiliang Xin, Tingting Yang, Jiawei Zhang, Ziqi Chen, Han Cai, Guanghong Sun, Qirui Guo, Hua Zhang, Bo Zhou
Publikováno v:
Journal of Molecular Cell Biology
Establishment of the primordial follicle (PF) pool is pivotal for the female reproductive lifespan; however, the mechanism of primordial folliculogenesis is poorly understood. Here, the transcription factor SP1 was shown to be essential for PF format
Autor:
Edward David Meza, Mi Zhang, Yonglun Luo, E Tian, Gerardo Felix, Lizhao Feng, Wendong Li, Tao Zhou, Yanhong Shi, Joseph D. Gold, Lucy Ghoda, David S. Hsu, Xianwei Chen, Weidong Hu, Peng Ye, Yue Qin, Jeremy Klein, Reuben Matalon, Li Li, Steven A. Goldman, Wei Dang, Qi Cui, Jianfei Chao, Guihua Sun
Publikováno v:
Adv Sci (Weinh)
Canavan disease (CD) is a leukodystrophy caused by aspartoacylase (ASPA) gene mutation with no cure so far. In this study, a functional ASPA was introduced into patient iPSC‐derived neural progenitor cells (iNPCs) and the engineered ASPA iNPCs coul