Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Lizette Sturgeon"'
Autor:
Kelly M. Loyet, Lisa A. Damico-Beyer, Jeremy Good, Kha Le, Xiangdan Wang, Philip E. Hass, Laura DeForge, Teresa Davancaze, Jihong Yang, Alyssa Morimoto, Lizette Sturgeon, Menno van Lookeren Campagne, Maureen Wong, Peter Haughney
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 351:527-537
Anti-factor D (AFD; FCFD4514S, lampalizumab) is a humanized IgG Fab fragment directed against factor D (fD), a rate-limiting serine protease in the alternative complement pathway (AP). Evaluation of AFD as a potential intravitreal (IVT) therapeutic f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff87804fcd99c185604a27c050704d1f
https://doi.org/10.1124/jpet.114.215921
https://doi.org/10.1124/jpet.114.215921
Autor:
Scott Stawicki, Kelly M. Loyet, Hongkang Xi, Christian Wiesmann, Lizette Sturgeon, Kenneth J. Katschke, Philip E. Hass, Yan Wu, Laura DeForge, Jianping Yin, Menno van Lookeren Campagne, Micah Steffek
Publikováno v:
Journal of Biological Chemistry. 284:10473-10479
Amplification of the complement cascade through the alternative pathway can lead to excessive inflammation. Targeting C3b, a component central to the alternative pathway of complement, provides a powerful approach to inhibit complement-mediated immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee3d14cb6bd3a3af0c73508404e9c38
https://doi.org/10.1074/jbc.m809106200
https://doi.org/10.1074/jbc.m809106200
Autor:
Kelly M. Loyet, Robert R. Graham, Lily Pao, Menno van Lookeren Campagne, Laura DeForge, Kenneth J. Katschke, Lizette Sturgeon, Joe G. Hollyfield, Sock Cheng Lewin-Koh, Lauri Diehl
Publikováno v:
Investigative ophthalmologyvisual science. 53(10)
PURPOSE. To determine if the progression of age-related macular degeneration (AMD) is associated with complement activation in the eye. METHODS. Immunohistochemistry and ELISAs were used to determine the distribution, concentration, and activation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd466b35f1d6bd893a5fd2c09468c584
https://pubmed.ncbi.nlm.nih.gov/22930722
https://pubmed.ncbi.nlm.nih.gov/22930722
Autor:
Sachdev S. Sidhu, Jason Chinn, Lauri Diehl, Menno van Lookeren Campagne, Laura DeForge, Bing Li, Wyne P. Lee, Christian Wiesmann, Lizette Sturgeon, Hongkang Xi, Robert F. Kelley
Publikováno v:
The Journal of biological chemistry. 284(51)
CRIg is a recently discovered complement C3 receptor expressed on a subpopulation of tissue-resident macrophages. The extracellular IgV domain of CRIg (CRIg-ECD) holds considerable promise as a potential therapeutic because it selectively inhibits th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00391435d453679b7965baa42c4077ce
https://pubmed.ncbi.nlm.nih.gov/19833734
https://pubmed.ncbi.nlm.nih.gov/19833734