The Angiotensin AT2Receptor: From a Binding Site to a Novel Therapeutic Target

Autor: U. Muscha Steckelings, Robert E. Widdop, Edward D. Sturrock, Lizelle Lubbe, Tahir Hussain, Elena Kaschina, Thomas Unger, Anders Hallberg, Robert M. Carey, Colin Sumners

Publikováno v: Pharmacological Reviews. 74:1051-1135

Discovered more than 30 years ago, the angiotensin AT2 receptor (AT2R) has evolved from a binding site with unknown function to a firmly established major effector within the protective arm of the renin-angiotensin system (RAS) and a target for new d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed01bea095fdd625441059db2d80f05
https://doi.org/10.1124/pharmrev.120.000281

Cryo‐EM reveals mechanisms of angiotensin I‐converting enzyme allostery and dimerization

Autor: Lizelle Lubbe, Bryan Trevor Sewell, Jeremy D Woodward, Edward D Sturrock

Publikováno v: The EMBO Journal. 41

Hypertension (high blood pressure) is a major risk factor for cardiovascular disease, which is the leading cause of death worldwide. The somatic isoform of angiotensin I-converting enzyme (sACE) plays a critical role in blood pressure regulation, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa9e790b63b0e40376ae3aef2f670fb
https://doi.org/10.15252/embj.2021110550

ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoV

Autor: K. Ravi Acharya, Lizelle Lubbe, Delia Oosthuizen, Gyles E. Cozier, Edward D. Sturrock

Publikováno v: Clinical Science
Clinical Science (London, England : 1979)

Angiotensin converting enzyme (ACE) is well-known for its role in blood pressure regulation via the renin–angiotensin aldosterone system (RAAS) but also functions in fertility, immunity, haematopoiesis and diseases such as obesity, fibrosis and Alz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f1d6d8ee7386e984aefeff3c956cb3
https://doi.org/10.1042/cs20200899

Epitope mapping of novel monoclonal antibodies to human angiotensin I‐converting enzyme

Autor: Edward D. Sturrock, Sergei M. Danilov, Steven M. Dudek, Elena R. Chernykh, Alexander V. Lyubimov, Isolda A. Popova, Pavel A. Petukhov, Olga Leplina, Joe G.N. Garcia, Ilya Trakht, Lizelle Lubbe, Kalantarov Gavriil F

Publikováno v: Protein Sci

Angiotensin I-converting enzyme (ACE, CD143) plays a crucial role in blood pressure regulation, vascular remodeling, and immunity. A wide spectrum of mAbs to different epitopes on the N and C domains of human ACE have been generated and used to study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b2c024d27bbd2576abcbf90ec21843
https://europepmc.org/articles/PMC8284578/

ACE-domain selectivity extends beyond direct interacting residues at the active site

Autor: Gyles E. Cozier, Lizelle Lubbe, Edward D. Sturrock, K.R. Acharya

Publikováno v: Cozier, G, Lubbe, L, Sturrock, E & Acharya, R 2020, ' ACE-domain selectivity extends beyond direct interacting residues at the active site ', Biochemical Journal, vol. 477, no. 7, pp. 1241-1259 . https://doi.org/10.1042/BCJ20200060
Biochemical Journal

Angiotensin-converting enzyme (ACE) is best known for its formation of the vasopressor angiotensin II that controls blood pressure but is also involved in other physiological functions through the hydrolysis of a variety of peptide substrates. The en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9c544569721bb601420dc617dfb8f9
https://purehost.bath.ac.uk/ws/files/204588204/Cozier_et_al_Accepted_version_19_Mar_2020.pdf