Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Lize Deferme"'
Autor:
Peter J. Boogaard, Jochen Buschmann, Wolfgang Koch, Hans B. Ketelslegers, Rainer Fuhst, Katharina Schwarz, Christine McAlinden, Mathieu Vaissiere, Anna Steneholm, Katharina Blümlein, Dirk Schaudien, Lize Deferme
Publikováno v:
Reproductive Toxicology. 99:15-26
The prenatal developmental toxicity of bitumen fume was tested by nose-only inhalation in the rat. The fumes for exposure were collected from the headspace of a storage tank filled with a bitumen corresponding in composition to an anticipated worst-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e283286da0632d461bdd321c509307
https://doi.org/10.1016/j.reprotox.2020.11.009
https://doi.org/10.1016/j.reprotox.2020.11.009
Autor:
Evelien Frijns, An Jacobs, Lize Deferme, Sylvie Remy, Sandra Verstraelen, Karen Hollanders, Masha Van Deun, Hilda Witters, Lieve Geerts, Diane Bertels, Rob Brabers, Jo Van Laer
Publikováno v:
Alternatives to animal experimentation
The goal is to optimize and show the validity of an in vitro method for inhalation testing of petroleum substances and their constituents at the air-liquid interface (ALI). The approach is demonstrated in a pilot study with ethylbenzene (EB), a mono-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a55b45816de3b09ca3c68eaf2ce9bd45
https://repository.uantwerpen.be/docstore/d:irua:9856
https://repository.uantwerpen.be/docstore/d:irua:9856
Autor:
Tewes Tralau, Roland Buesen, Jim Bridges, Mark Pemberton, Ben van Ravenzwaay, Alan Poole, Lize Deferme, Ursula G. Sauer, Knut E. Tollefsen
Publikováno v:
Regulatory Toxicology and Pharmacology. 91:S46-S60
A framework for the quantitative weight-of-evidence (QWoE) analysis of 'omics data for regulatory purposes is presented. The QWoE framework encompasses seven steps to evaluate 'omics data (also together with non-'omics data): (1) Hypothesis formulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef1274bdffc622c9fec01a54868d8f5
https://doi.org/10.1016/j.yrtph.2017.10.010
https://doi.org/10.1016/j.yrtph.2017.10.010
Autor:
J. Richard Wagner, Simone G. J. van Breda, Jos C. S. Kleinjans, Lize Deferme, Sandra M.H. Claessen, Jacco J. Briedé, Daniel H. J. Theunissen, Twan van den Beucken, Jarno E J Wolters
Publikováno v:
Chemical Research in Toxicology, 29(9), 1428-1438. American Chemical Society
In recent years, it has been shown that free radicals not only react directly with DNA but also regulate epigenetic processes such as DNA methylation, which may be relevant within the context of, for example, tumorigenesis. However, how these free ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991cccc40c9d2d1aa0ca3073c09f1705
https://doi.org/10.1021/acs.chemrestox.6b00090
https://doi.org/10.1021/acs.chemrestox.6b00090
Autor:
Jos C. S. Kleinjans, Sandra M.H. Claessen, Simone G. J. van Breda, Lize Deferme, Jarno E J Wolters, Jacob J. Briedé, Twan van den Beucken, Richard Wagner
Publikováno v:
Toxicology in Vitro, 48, 318-328. Elsevier Science
Regulation of DNA methylation plays a crucial role in biological processes and carcinogenesis. The formation of 5-hydroxymethylcytosine (5hmC) by oxidation of 5-methylcytosine (5mC) has been proposed as an intermediate of active demethylation. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d56fa1ab2382e59292505a5c2cf8067
https://cris.maastrichtuniversity.nl/en/publications/207e0e71-6e7f-4923-aa43-261ef38a9ae7
https://cris.maastrichtuniversity.nl/en/publications/207e0e71-6e7f-4923-aa43-261ef38a9ae7
Oxidative Stress Mechanisms Do Not Discriminate between Genotoxic and Nongenotoxic Liver Carcinogens
Publikováno v:
Chemical Research in Toxicology, 28(8), 1636-1646. American Chemical Society
It is widely accepted that in chemical carcinogenesis different modes-of-action exist, e.g., genotoxic (GTX) versus non-genotcodc (NGTX) carcinogenesis. In this context, it has been suggested that oxidative stress response pathways are typical for NG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04de728fa7956e431ba2c87d0c4fc407
https://doi.org/10.1021/acs.chemrestox.5b00222
https://doi.org/10.1021/acs.chemrestox.5b00222
Publikováno v:
Toxicology in Vitro, 29(5), 845-855. Elsevier Science
Imbalance between high reactive oxygen species formation and antioxidant capacity in the colon and liver has been linked to increased cancer risk. However, knowledge about possible cell line-specific oxidative stress-mechanisms is limited. To explore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55079eff2d90951cc9fb8745a3edd054
https://doi.org/10.1016/j.tiv.2015.03.007
https://doi.org/10.1016/j.tiv.2015.03.007
Autor:
Tewes Tralau, Regine Fuchs, Knut E. Tollefsen, Hennicke Kamp, Ben van Ravenzwaay, Jörg Hackermüller, Stefania Perdichizzi, Hans-Martin Kauffmann, Timothy M. D. Ebbels, Carole L. Yauk, Ursula G. Sauer, Lize Deferme, Brian N. Chorley, Alan Poole
Publikováno v:
S35
S27
S27
‘Omics technologies are gaining importance to support regulatory toxicity studies. Prerequisites for performing ‘omics studies considering GLP principles were discussed at the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3533e927ebc27a7dc84ffc4b04b33764
http://hdl.handle.net/10044/1/56974
http://hdl.handle.net/10044/1/56974
Autor:
Ben van Ravenzwaay, Jörg Hackermüller, Alan Poole, Ursula G. Sauer, Laura Gribaldo, Timothy W. Gant, Lize Deferme, Carole L. Yauk, Tewes Tralau, Weida Tong
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 91
This survey by the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) highlights that 'omics technologies are generally not yet applied to meet standard information requirements during regulatory hazard assessment. While they are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb20a3ee49d728e8108882e72cc3ef0
https://pubmed.ncbi.nlm.nih.gov/28927750
https://pubmed.ncbi.nlm.nih.gov/28927750
Autor:
Sandra, Verstraelen, An, Jacobs, Jo, Van Laer, Masha, Van Deun, Diane, Bertels, Witters, Hilda, Sylvie, Remy, Lieve, Geerts, Lize, Deferme, Evelien, Frijns
Publikováno v:
In MethodsX 2020 7