Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lizbeth Lockwood"'
Autor:
Di Zhang, Bijay Singh, Jessica Moerland, Owen Mitchell, Lizbeth Lockwood, Sarah Carapellucci, Srinivas Sridhar, Karen T. Liby
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Mutations in BRCA genes are the leading cause of hereditary breast cancer. Current options to prevent cancer in these high-risk patients, such as anti-estrogen drugs and radical mastectomy, are limited by lack of efficacy, undesirable toxici
Externí odkaz:
https://doaj.org/article/40f3abc1cc2a42d1872ad1437fb1b359
Autor:
Zhilin Hou, Lizbeth Lockwood, Di Zhang, Christopher J. Occhiuto, Linqing Mo, Kelly E. Aldrich, Hayden E. Stoub, Kathleen A. Gallo, Karen T. Liby, Aaron L. Odom
Publikováno v:
RSC Medicinal Chemistry. 14:74-84
SAR on NRF2 inhibitor MSU38225 has led to a compound that inhibits expression of NRF2 target genes, reduces proliferation of lung cancer cells through G2/M arrest, and lowers cell migration.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d2c7ef46dbd6bb13d4a8a841fe4508a
https://doi.org/10.1039/d2md00211f
https://doi.org/10.1039/d2md00211f
Suppl Fig. 1 lists the primer sequences for NFE2L2 and downstream gene targets of Nrf2. Suppl Fig. 2 shows that MSU38225 does not alter the overall expression pattern of abundant cellular proteins. Suppl Fig. 3 shows that MSU38225 does not inhibit th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e5360b093c1e0921559c8e8d7014cc
https://doi.org/10.1158/1535-7163.22523014
https://doi.org/10.1158/1535-7163.22523014
The nuclear factor erythroid-2-related factor 2 (Nrf2)–Keap1–ARE pathway, a master regulator of oxidative stress, has emerged as a promising target for cancer therapy. Mutations in NFE2L2, KEAP1, and related genes have been found in many human ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963cfc4696c6f6bddc7263bdfd011a18
https://doi.org/10.1158/1535-7163.c.6543550.v1
https://doi.org/10.1158/1535-7163.c.6543550.v1
Publikováno v:
Cancer Research. 83:3648-3648
Neurofibromatosis type 1 (NF1) is a common genetic disease that predisposes approximately 50% of affected individuals to develop plexiform neurofibromas (PNFs), which can progress to highly aggressive malignant peripheral nerve sheath tumors (MPNSTs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f85cdd2aa14cf02c909012e1504e7940
https://doi.org/10.1158/1538-7445.am2023-3648
https://doi.org/10.1158/1538-7445.am2023-3648
Autor:
Srinivas Sridhar, Karen T. Liby, Jessica A. Moerland, Lizbeth Lockwood, Bijay Singh, Di Zhang, Sarah Carapellucci, Owen Mitchell
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports
Mutations in BRCA genes are the leading cause of hereditary breast cancer. Current options to prevent cancer in these high-risk patients, such as anti-estrogen drugs and radical mastectomy, are limited by lack of efficacy, undesirable toxicities, or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6802d6489eb27bb510b2eb582eb8b4
https://doaj.org/article/40f3abc1cc2a42d1872ad1437fb1b359
https://doaj.org/article/40f3abc1cc2a42d1872ad1437fb1b359
Publikováno v:
Mol Cancer Ther
The nuclear factor erythroid-2-related factor 2 (Nrf2)–Keap1–ARE pathway, a master regulator of oxidative stress, has emerged as a promising target for cancer therapy. Mutations in NFE2L2, KEAP1, and related genes have been found in many human ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08b1bf14f83e6dd585566c60e3d4307
https://pubmed.ncbi.nlm.nih.gov/34158350
https://pubmed.ncbi.nlm.nih.gov/34158350
Autor:
Bijay Singh, Srinivas Sridhar, Sarah Carapellucci, Lizbeth Lockwood, Jessica A. Moerland, Di Zhang, Owen Mitchell, Karen T. Liby
Publikováno v:
Cancer Research. 80:12-12
Mutations in BRCA genes are the leading cause of hereditary breast cancer and dramatically increase the lifetime risk of developing breast cancer. Anti-estrogen drugs are approved to reduce the risk of developing invasive breast cancer, but they are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69c84f0c1a51e5fb3201dac09befef83
https://doi.org/10.1158/1538-7445.am2020-12
https://doi.org/10.1158/1538-7445.am2020-12
Publikováno v:
Pediatrics. 144:608-608
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8fc6470d3ceeb50b57df59b3730feb9
https://doi.org/10.1542/peds.144.2ma7.608
https://doi.org/10.1542/peds.144.2ma7.608
Publikováno v:
Pediatrics. 141:579-579
Purpose: Injury to the intestinal mucosa with loss of epithelial barrier integrity is a pathophysiologic hallmark of necrotizing enterocolitis (NEC). Several key mediators of gastrointestinal wound healing have been identified including prostanoids s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a30f24ab1ecbddc2d827962e6daa33
https://doi.org/10.1542/peds.141.1ma6.579
https://doi.org/10.1542/peds.141.1ma6.579