Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Lizbeth Celeste Deselm"'
Autor:
Brian H. Heasley, Jing Lin, Thomas F. N. Haxell, Igor Mochalkin, Constantin Neagu, Felix Rohdich, Ruoxi Lan, Amanda E. Sutton, Jennifer Jackson, Potnick Justin, Bayard R. Huck, Andreas Machl, Katrin Georgi, Xiaoling Chen, Sherer Brian A, Erik Wilker, Thomas E. Richardson, Anderson Clark, Reinaldo Jones, Johnson Theresa L, Lizbeth Celeste Deselm, Andreas Goutopoulos, Hui Tian, Yufang Xiao, Joseph A. Moore, Lindsey Crowley
Publikováno v:
Journal of Medicinal Chemistry. 64:14603-14619
Herein, we report the discovery of a novel class of quinazoline carboxamides as dual p70S6k/Akt inhibitors for the treatment of tumors driven by alterations to the PI3K/Akt/mTOR (PAM) pathway. Through the screening of in-house proprietary kinase libr
Autor:
Ruoxi Lan, Hui Tian, Dusica Santos, Lizbeth Celeste Deselm, Jing Lin, Donald Bankston, Constantin Neagu, Sherer Brian A, Jennifer Jackson, Jared Head, Jianguo Ma, Xuliang Jiang, Sakeena Syed, Anderson Clark, Andreas Machl, Yufang Xiao, Erik Wilker, Anna Gardberg, Xiaoling Chen, Igor Mochalkin, Bayard R. Huck, Hui Qiu, Christopher Charles Victor Jones, Vikram Dutt, Johnson Theresa L, Andreas Goutopoulos
Publikováno v:
Bioorganicmedicinal chemistry letters. 50
Activation of the PI3K/Akt/mTOR kinase pathway is associated with human cancers. A dual p70S6K/Akt inhibitor is sufficient to inhibit strong tumor growth and to block negative impact of the compensatory Akt feedback loop activation. A scaffold dockin