Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Lizbeth Hedstrom"'
Autor:
Mary F. Roberts, Lizbeth Hedstrom
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The dynamic interactions of enzymes and substrates underpins catalysis, yet few techniques can interrogate the dynamics of protein-bound ligands. Here we describe the use of field cycling NMR relaxometry to measure the dynamics of enzyme-bound substr
Externí odkaz:
https://doaj.org/article/45977af52f6c4751bc19096f84e99af2
Autor:
Lizbeth Hedstrom, Farid El Oualid, Eranthie Weerapana, Yu Qian, Rory T. Coffey, Marcus J.C. Long, Ann P. Lawson
Naturally occurring ITCs cause HMW-Ub accumulation in BaF3 cells (S1); Naturally occurring ITCs do not inhibit the proteasome (S2); Natural ITCs have few functional cysteine targets in cells (S3); Activity profiling shows PEITC and BITC inhibit USP9x
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486df2da85da272da3e0d0c62a7dd0d9
https://doi.org/10.1158/0008-5472.22405715
https://doi.org/10.1158/0008-5472.22405715
Autor:
Lizbeth Hedstrom, Farid El Oualid, Eranthie Weerapana, Yu Qian, Rory T. Coffey, Marcus J.C. Long, Ann P. Lawson
Description of additional methods and procedures used in the study. Also includes Supplementary References.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fdcec4bb8567f4df3c15ddc87f1b698
https://doi.org/10.1158/0008-5472.22405712.v1
https://doi.org/10.1158/0008-5472.22405712.v1
Autor:
Deviprasad R. Gollapalli, Gregory D. Cuny, Adhar C. Manna, Natalia Maltseva, Barry B. Snider, Yubo Zhang, Mohana Rao Vippila, Ann P. Lawson, Lizbeth Hedstrom, Minjia Zhang, Youngchang Kim, David M Rothstein, Shibin Chacko, Petr Kuzmic, Xingyou Wang, Andrzej Joachimiak, Ryan T Cullinane, Gyan Modi, Gary M Marqus, Ambrose L. Cheung, Judy L.M. Kotler
Publikováno v:
ACS Infectious Diseases. 7:3062-3076
Many bacterial pathogens, including Staphylococcus aureus, require inosine 5'-monophosphate dehydrogenase (IMPDH) for infection, making this enzyme a promising new target for antibiotics. Although potent selective inhibitors of bacterial IMPDHs have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67a38314a14bd8ed48fa872a866f2505
https://doi.org/10.1021/acsinfecdis.1c00342
https://doi.org/10.1021/acsinfecdis.1c00342
Autor:
Susan Zhang, Kristin E. Burns-Huang, Guido V. Janssen, Huilin Li, Huib Ovaa, Lizbeth Hedstrom, K. Heran Darwin
Publikováno v:
mBio, Vol 8, Iss 1 (2017)
ABSTRACT The protein degradation machinery of Mycobacterium tuberculosis includes a proteasome and a ubiquitin-like protein (Pup). Proteasome accessory factor A (PafA) attaches Pup to proteins to target them for degradation by the proteasome. Free Pu
Externí odkaz:
https://doaj.org/article/d2b74ebe65b244948a736ea43510d1c5
Autor:
Michael J. Pepi, Shibin Chacko, Nicole Kopetz, Helena I.M. Boshoff, Gregory D. Cuny, Lizbeth Hedstrom
Publikováno v:
Bioorganicmedicinal chemistry letters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a371efcdf32f1e8861ec0d0550851a5d
https://pubmed.ncbi.nlm.nih.gov/36572353
https://pubmed.ncbi.nlm.nih.gov/36572353
Autor:
Seungheon Lee, Melissa S. Love, Ramkumar Modukuri, Arnab K. Chatterjee, Lauren Huerta, Ann P. Lawson, Case W. McNamara, Jan R. Mead, Lizbeth Hedstrom, Gregory D. Cuny
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 90:129328
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dcf446f9831cd2db958c5601a963e15
https://doi.org/10.1016/j.bmcl.2023.129328
https://doi.org/10.1016/j.bmcl.2023.129328
Autor:
Gregory C. Patton, Masha M. Rosenberg, Lizbeth Hedstrom, Alfred G. Redfield, Mary F. Roberts, Tianjiong Yao
Publikováno v:
Biochemistry
The remarkable power and specificity of enzyme catalysis rely on the dynamic alignment of the enzyme, substrates, and cofactors, yet the role of dynamics has usually been approached from the perspective of the protein. We have been using an underappr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eceae9f84a3f791bd8ad3779055875f
https://doi.org/10.1021/acs.biochem.0c00212
https://doi.org/10.1021/acs.biochem.0c00212
Autor:
Mary F, Roberts, Lizbeth, Hedstrom
Publikováno v:
Frontiers in molecular biosciences. 9
The dynamic interactions of enzymes and substrates underpins catalysis, yet few techniques can interrogate the dynamics of protein-bound ligands. Here we describe the use of field cycling NMR relaxometry to measure the dynamics of enzyme-bound substr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d7a3ef9fdc20d09513a227dfaa3ab6df
https://pubmed.ncbi.nlm.nih.gov/35433832
https://pubmed.ncbi.nlm.nih.gov/35433832
Autor:
Michael J, Pepi, Shibin, Chacko, Gary M, Marqus, Vinayak, Singh, Zhe, Wang, Kyle, Planck, Ryan T, Cullinane, Penchala N, Meka, Deviprasad R, Gollapalli, Thomas R, Ioerger, Kyu Y, Rhee, Gregory D, Cuny, Helena I M, Boshoff, Lizbeth, Hedstrom
Publikováno v:
ACS Infect Dis
New drugs and new targets are urgently needed to treat tuberculosis. We discovered the D-phenylalanine-benzoxazole Q112 displays potent antibacterial activity against Mycobacterium tuberculosis (Mtb) in multiple media and in macrophage infections. Me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::31a1ae83ee43ca779a5028edd621871f
https://pubmed.ncbi.nlm.nih.gov/35015509
https://pubmed.ncbi.nlm.nih.gov/35015509