Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Lizana, Ludvig"'
Chromosome capture techniques like Hi-C have expanded our understanding of mammalian genome 3D architecture and how it influences gene activity. To analyze Hi-C data sets, researchers increasingly treat them as DNA-contact networks and use standard c
Externí odkaz:
http://arxiv.org/abs/2405.05425
Cells regulate fates and complex body plans using spatiotemporal signaling cascades that alter gene expression. Enhancers, short DNA sequences (50-150 base pairs), help coordinate these cascades by attracting regulatory proteins to enhance the transc
Externí odkaz:
http://arxiv.org/abs/2402.09209
Autor:
Hedström, Lucas, Lizana, Ludvig
The most common gene regulation mechanism is when a protein binds to a regulatory sequence to change RNA transcription. However, these sequences are short relative to the genome length, so finding them poses a challenging search problem. This paper p
Externí odkaz:
http://arxiv.org/abs/2311.11727
Publikováno v:
J. Phys. Complex. 4 035004 (2023)
Researchers developed chromosome capture methods such as Hi-C to better understand DNA's 3D folding in nuclei. The Hi-C method captures contact frequencies between DNA segment pairs across the genome. When analyzing Hi-C data sets, it is common to gr
Externí odkaz:
http://arxiv.org/abs/2302.14684
Publikováno v:
Sci Rep 13, 12979 (2023)
To better understand DNA's 3D folding in cell nuclei, researchers developed chromosome capture methods such as Hi-C that measure the contact frequencies between all DNA segment pairs across the genome. As Hi-C data sets often are massive, it is commo
Externí odkaz:
http://arxiv.org/abs/2212.08456
Autor:
Hedström, Lucas, Lizana, Ludvig
Publikováno v:
New J. Phys. 25 033024 (2023=
The most common gene regulation mechanism is when a transcription factor protein binds to a regulatory sequence to increase or decrease RNA transcription. However, transcription factors face two main challenges when searching for these sequences. Fir
Externí odkaz:
http://arxiv.org/abs/2211.04195
Chromosomes in the nucleus assemble into hierarchies of 3D domains that, during interphase, share essential features with a knot-free condensed polymer known as the fractal globule (FG). The FG-like chromosome likely affects macromolecular transport,
Externí odkaz:
http://arxiv.org/abs/2109.14933
The 3D organisation of the genome in interphase cells is not a randomly folded polymer. Rather, experiments show that chromosomes arrange into a network of 3D compartments that correlate with biological processes, such as transcription, chromatin mod
Externí odkaz:
http://arxiv.org/abs/1811.01578
Autor:
Lee, Sang Hoon, Kim, Yeonghoon, Lee, Sungmin, Durang, Xavier, Stenberg, Per, Jeon, Jae-Hyung, Lizana, Ludvig
Publikováno v:
Sci. Rep. 9, 6859 (2019)
Several experiments show that the three dimensional (3D) organization of chromosomes affects genetic processes such as transcription and gene regulation. To better understand this connection, researchers developed the Hi-C method that is able to dete
Externí odkaz:
http://arxiv.org/abs/1810.01307
Publikováno v:
In Journal of Biological Chemistry