Drosophila Vps13 Is Required for Protein Homeostasis in the Brain.

Autor: Jan J Vonk, Wondwossen M Yeshaw, Francesco Pinto, Anita I E Faber, Liza L Lahaye, Bart Kanon, Marianne van der Zwaag, Antonio Velayos-Baeza, Raimundo Freire, Sven C van IJzendoorn, Nicola A Grzeschik, Ody C M Sibon

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0170106 (2017)

Chorea-Acanthocytosis is a rare, neurodegenerative disorder characterized by progressive loss of locomotor and cognitive function. It is caused by loss of function mutations in the Vacuolar Protein Sorting 13A (VPS13A) gene, which is conserved from y

Externí odkaz: https://doaj.org/article/5fc263d2c7534130bc21e94d7fab48dd

Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility

Autor: Antonio Velayos-Baeza, Conor Poland, Amalia M. Dolga, Rubén Gómez-Sánchez, Anita I. E. Faber, Nicola A. Grzeschik, Anthony P. Monaco, Francesco Pinto, Ody C. M. Sibon, Wondwossen M Yeshaw, Liza L. Lahaye, Sven C.D. van IJzendoorn, Marianne van der Zwaag

Publikováno v: eLife, 8:43561. ELIFE SCIENCES PUBLICATIONS LTD
eLife, Vol 8 (2019)
eLife

The VPS13A gene is associated with the neurodegenerative disorder Chorea Acanthocytosis. It is unknown what the consequences are of impaired function of VPS13A at the subcellular level. We demonstrate that VPS13A is a peripheral membrane protein, ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7e32d594a9211f0604d270810eeb77
https://doi.org/10.7554/elife.43561

Guidance of Drosophila Mushroom Body Axons Depends upon DRL-Wnt Receptor Cleavage in the Brain Dorsomedial Lineage Precursors

Autor: Iveta M. Petrova, Jean-Maurice Dura, Elodie Reynaud, Claire Marquilly, Martin Privat, Jasprina N. Noordermeer, Liza L. Lahaye, Ana Boulanger, Lee G. Fradkin, Tania Martianez, Adrien Flandre

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2015, 11 (8), pp.1293-1304. ⟨10.1016/j.celrep.2015.04.035⟩
Cell Reports, Vol 11, Iss 8, Pp 1293-1304 (2015)

Summary In vivo axon pathfinding mechanisms in the neuron-dense brain remain relatively poorly characterized. We study the Drosophila mushroom body (MB) axons, whose α and β branches connect to different brain areas. We show that the Ryk family WNT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1be69d5a7ba49cc91aa9657e8e85245
https://hal.archives-ouvertes.fr/hal-01159650/document

Homodimerization of the Wnt Receptor DERAILED Recruits the Src Family Kinase SRC64B

Autor: Jasprina N. Noordermeer, Liza L. Lahaye, Iveta M. Petrova, Lee G. Fradkin, Anja W. M. de Jong, Martijn J. A. Malessy, Joost Verhaagen, Tania Martianez

Publikováno v: Molecular and Cellular Biology, 33, 4116-4127. American Society for Microbiology
Molecular and Cellular Biology, 33(20), 4116-4127

Ryk pseudokinase receptors act as important transducers of Wnt signals, particularly in the nervous system. Little is known, however, of their interactions at the cell surface. Here, we show that a Drosophila Ryk family member, DERAILED (DRL), forms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::567a99c957dc510466ccb4e22f243dbe
https://hdl.handle.net/1887/99909

Guidance of Drosophila Mushroom Body Axons Depends upon DRL-Wnt Receptor Cleavage in the Brain Dorsomedial Lineage Precursors

Autor: Elodie Reynaud, Liza L. Lahaye, Ana Boulanger, Iveta M. Petrova, Claire Marquilly, Adrien Flandre, Tania Martianez, Martin Privat, Jasprina N. Noordermeer, Lee G. Fradkin, Jean-Maurice Dura

Publikováno v: Cell Reports, Vol 11, Iss 8, Pp 1293-1304 (2015)

In vivo axon pathfinding mechanisms in the neuron-dense brain remain relatively poorly characterized. We study the Drosophila mushroom body (MB) axons, whose α and β branches connect to different brain areas. We show that the Ryk family WNT5 recept

Externí odkaz: https://doaj.org/article/200f617be84d40088ed02af0586f1252