Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Liza Cubeddu"'
Autor:
Didier Boucher, Ruvini Kariawasam, Joshua Burgess, Adrian Gimenez, Tristan E. Ocampo, Blake Ferguson, Ali Naqi, Graeme J. Walker, Emma Bolderson, Roland Gamsjaeger, Kenneth J. O’Byrne, Liza Cubeddu, Kum Kum Khanna, Derek J. Richard
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Maintenance of genomic stability is critical to prevent diseases such as cancer. As such, eukaryotic cells have multiple pathways to efficiently detect, signal and repair DNA damage. One common form of exogenous DNA damage comes from ultravi
Externí odkaz:
https://doaj.org/article/991568c68db64a919a589c680930eeaa
Autor:
Teegan Lawson, Serene El-Kamand, Ruvini Kariawasam, Derek J. Richard, Liza Cubeddu, Roland Gamsjaeger
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 441-446 (2019)
Single-stranded DNA binding (SSB) proteins are essential to protect singe-stranded DNA (ssDNA) that exists as a result of several important DNA repair pathways in living cells. In humans, besides the well-characterised Replication Protein A (RPA) we
Externí odkaz:
https://doaj.org/article/f96194e96ac8474e939d5b146e9728f1
Autor:
Soumya Joseph, Ann H Kwan, Philippa H Stokes, Joel P Mackay, Liza Cubeddu, Jacqueline M Matthews
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109108 (2014)
LIM-domain only protein 4 (LMO4) is a widely expressed protein with important roles in embryonic development and breast cancer. It has been reported to bind many partners, including the transcription factor Deformed epidermal autoregulatory factor-1
Externí odkaz:
https://doaj.org/article/093749faa0124e2ea08beea63a3356a5
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39218 (2012)
The proteins LMO4 and DEAF1 contribute to the proliferation of mammary epithelial cells. During breast cancer LMO4 is upregulated, affecting its interaction with other protein partners. This may set cells on a path to tumour formation. LMO4 and DEAF1
Externí odkaz:
https://doaj.org/article/811f90489a804e098a98e159490a72dd
Autor:
Tej K. Pandita, Jerry W. Shay, Kum Kum Khanna, Woodring E. Wright, Yong Zhao, Nobuo Horikoshi, Wei Shi, Clayton R. Hunt, Liza Cubeddu, Amanda L. Bain, Durga Udayakumar, Tracy T. Chow, Raj K. Pandita
Supplementary Figure Legend, Methods and Materials, Tables 1-2. Supplementary Table 1. Phase distribution in cells after enrichment by synchronization. Supplementary Table 2. Effect of Ssb1 depletion on spontaneous chromosome aberration frequency.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9376887e2277d860429acc3b9d1d1a85
https://doi.org/10.1158/0008-5472.22408032.v1
https://doi.org/10.1158/0008-5472.22408032.v1
Autor:
Tej K. Pandita, Jerry W. Shay, Kum Kum Khanna, Woodring E. Wright, Yong Zhao, Nobuo Horikoshi, Wei Shi, Clayton R. Hunt, Liza Cubeddu, Amanda L. Bain, Durga Udayakumar, Tracy T. Chow, Raj K. Pandita
Supplementary Figures 1-5. Supplementary Fig. 1. Analysis of single-strand G-overhang by native and denatured DNA gel electrophoresis. Supplementary Fig. 2. Telomere FISH analysis of chromosomal aberrations induced by Ssb1 depletion in mouse and huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44723f8f316ecae9017804c6826b09a4
https://doi.org/10.1158/0008-5472.22408029
https://doi.org/10.1158/0008-5472.22408029
Autor:
Tej K. Pandita, Jerry W. Shay, Kum Kum Khanna, Woodring E. Wright, Yong Zhao, Nobuo Horikoshi, Wei Shi, Clayton R. Hunt, Liza Cubeddu, Amanda L. Bain, Durga Udayakumar, Tracy T. Chow, Raj K. Pandita
Proliferating mammalian stem and cancer cells express telomerase [telomerase reverse transcriptase (TERT)] in an effort to extend chromosomal G-overhangs and maintain telomere ends. Telomerase-expressing cells also have higher levels of the single-st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33d699f59cee1d137562b5d706ffd738
https://doi.org/10.1158/0008-5472.c.6507444.v1
https://doi.org/10.1158/0008-5472.c.6507444.v1
Autor:
Liza Cubeddu, Sam Beard, Roland Gamsjaeger, Ann H. Kwan, Lexie Johnson, Mar Dean Du Plessis, Derek J. Richard, Serene El-Kamand, Natasha Breen
Publikováno v:
Proteins
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a novel, highly infectious RNA virus that belongs to the coronavirus family. Replication of the viral genome is a fundamental step in the virus life cycle and SARS‐CoV‐2 non‐st
Autor:
Lexie Johnson, Natasha Breen, Roland Gamsjaeger, Ann H. Kwan, Mar-Dean Du Plessis, Liza Cubeddu, Derek J. Richard, Serene El-Kamand, Sam Beard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db6383700af548895ae4212faa9477c6
https://doi.org/10.1002/prot.26205/v2/response1
https://doi.org/10.1002/prot.26205/v2/response1
Autor:
Laura V. Croft, Serene El-Kamand, Emma Bolderson, Liza Cubeddu, Ruvini Kariawasam, Mark N. Adams, Derek J. Richard, Roland Gamsjaeger
Publikováno v:
Seminars in Cell & Developmental Biology. 86:121-128
Our genomic DNA is found predominantly in a double-stranded helical conformation. However, there are a number of cellular transactions and DNA damage events that result in the exposure of single stranded regions of DNA. DNA transactions require these