Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Liza Colhoun"'
Autor:
Mei Chen, Josephine V Glenn, Shilpa Dasari, Carmel McVicar, Michael Ward, Liza Colhoun, Michael Quinn, Angelika Bierhaus, Heping Xu, Alan W Stitt
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89548 (2014)
RAGE regulates pro-inflammatory responses in diverse cells and tissues. This study has investigated if RAGE plays a role in immune cell mobilization and choroidal neovascular pathology that is associated with the neovascular form of age-related macul
Externí odkaz:
https://doaj.org/article/0e9b71df86b5484f80bdc8f515c1ffe6
Autor:
Mei Chen, Jose R Hombrebueno, Chang Luo, Rosana Penalva, Jiawu Zhao, Liza Colhoun, Sudha Pirya Soundara Pandi, John V Forrester, Heping Xu
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61381 (2013)
Previous studies have shown that CCL2/CX3CR1 deficient mice on C57BL/6N background (with rd8 mutation) have an early onset (6 weeks) of spontaneous retinal degeneration. In this study, we generated CCL2(-/-)CX3CR1(GFP/GFP) mice on the C57BL/6J backgr
Externí odkaz:
https://doaj.org/article/4196744f55274fb18c65bf0d1e52bc03
Autor:
Micheal S. Ward, Carmel M. McVicar, M Kolibabka, Andreas Schlotterer, Hans-Peter Hammes, Angelika Bierhaus, Mei Chen, Jasenka Guduric-Fuchs, Liza Colhoun, Thomas Fleming, Alan W. Stitt
Publikováno v:
Diabetologia
McVicar, C M, Ward, M, Colhoun, L M, Guduric-Fuchs, J, Bierhaus, A, Fleming, T, Schlotterer, A, Kolibabka, M, Hammes, H-P, Chen, M & Stitt, A W 2015, ' Role of the receptor for advanced glycation endproducts (RAGE) in retinal vasodegenerative pathology during diabetes in mice ', Diabetologia, vol. 58, no. 5, pp. 1129-37 . https://doi.org/10.1007/s00125-015-3523-x
McVicar, C M, Ward, M, Colhoun, L M, Guduric-Fuchs, J, Bierhaus, A, Fleming, T, Schlotterer, A, Kolibabka, M, Hammes, H-P, Chen, M & Stitt, A W 2015, ' Role of the receptor for advanced glycation endproducts (RAGE) in retinal vasodegenerative pathology during diabetes in mice ', Diabetologia, vol. 58, no. 5, pp. 1129-37 . https://doi.org/10.1007/s00125-015-3523-x
Aims/hypothesis The receptor for AGEs (RAGE) is linked to proinflammatory pathology in a range of tissues. The objective of this study was to assess the potential modulatory role of RAGE in diabetic retinopathy. Methods Diabetes was induced in wild-t
Autor:
Michael Brines, Ross Hamilton, Carmel M. McVicar, Tom A. Gardiner, Anthony Cerami, Liza Colhoun, Alan W. Stitt
Publikováno v:
Diabetes
OBJECTIVE Erythropoietin (EPO) may be protective for early stage diabetic retinopathy, although there are concerns that it could exacerbate retinal angiogenesis and thrombosis. A peptide based on the EPO helix-B domain (helix B-surface peptide [pHBSP
Autor:
Ronald A. Schachar, Wei Chen, J. Keenan, Yuebin Li, Liza Colhoun, Barbara K. Pierscionek, Akeel A. Yasseen
Publikováno v:
Current Analytical Chemistry. 6:172-176
The transparency of the eye lens is vital for maintenance of good image quality to the eye. This is lost when the lens develops a cataract which is a manifestation of changes to the structural proteins and their organisation. Understanding the comple
Autor:
J. V. Glenn, Alan W. Stitt, Angelika Bierhaus, Michael P. Quinn, Heping Xu, Carmel M. McVicar, Liza Colhoun, Mei Chen, Shilpa Dasari, Michael Ward
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89548 (2014)
PLoS ONE
Chen, M, Glenn, J V, Dasari, S, McVicar, C, Ward, M, Colhoun, L, Quinn, M, Bierhaus, A, Xu, H & Stitt, A W 2014, ' RAGE Regulates Immune Cell Infiltration and Angiogenesis in Choroidal Neovascularization ', PloS one, vol. 9, no. 2, e89548, pp. 1-11 . https://doi.org/10.1371/journal.pone.0089548
PLoS ONE
Chen, M, Glenn, J V, Dasari, S, McVicar, C, Ward, M, Colhoun, L, Quinn, M, Bierhaus, A, Xu, H & Stitt, A W 2014, ' RAGE Regulates Immune Cell Infiltration and Angiogenesis in Choroidal Neovascularization ', PloS one, vol. 9, no. 2, e89548, pp. 1-11 . https://doi.org/10.1371/journal.pone.0089548
Purpose: RAGE regulates pro-inflammatory responses in diverse cells and tissues. This study has investigated if RAGE plays a role in immune cell mobilization and choroidal neovascular pathology that is associated with the neovascular form of age-rela
Autor:
Rosana Penalva, Jose R. Hombrebueno, Jiawu Zhao, Sudha Pirya Soundara Pandi, Mei Chen, John V. Forrester, Chang Luo, Heping Xu, Liza Colhoun
Publikováno v:
PLoS ONE
Chen, M, Hombrebueno, J R, Luo, C, Penalva, R, Zhao, J, Colhoun, L, Pandi, S P S, Forrester, J V & Xu, H 2013, ' Age-and Light-Dependent Development of Localised Retinal Atrophy in CCL2(-/-)CX3CR1(GFP/GFP) Mice ', PLoS ONE, vol. 8, no. 4, e61381 . https://doi.org/10.1371/journal.pone.0061381
PLoS ONE, Vol 8, Iss 4, p e61381 (2013)
Chen, M, Hombrebueno, J R, Luo, C, Penalva, R, Zhao, J, Colhoun, L, Pandi, S P S, Forrester, J V & Xu, H 2013, ' Age-and Light-Dependent Development of Localised Retinal Atrophy in CCL2(-/-)CX3CR1(GFP/GFP) Mice ', PLoS ONE, vol. 8, no. 4, e61381 . https://doi.org/10.1371/journal.pone.0061381
PLoS ONE, Vol 8, Iss 4, p e61381 (2013)
Previous studies have shown that CCL2/CX3CR1 deficient mice on C57BL/6N background (with rd8 mutation) have an early onset (6 weeks) of spontaneous retinal degeneration. In this study, we generated CCL2(-/-)CX3CR1(GFP/GFP) mice on the C57BL/6J backgr
Autor:
Denise McDonald, Adrian Devine, Nuria Matesanz, Tom A. Gardiner, Laura Stevenson, Liza Colhoun, Kevin Edgar
Neovascularization occurs in response to tissue ischemia and growth factor stimulation. In ischemic retinopathies, however, new vessels fail to restore the hypoxic tissue; instead, they infiltrate the transparent vitreous. In a model of oxygen-induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e25fd2826cc623f075f312a3d959114a
https://europepmc.org/articles/PMC2891480/
https://europepmc.org/articles/PMC2891480/
Autor:
Phillip McKeag, Youyou Zhao, Liza Colhoun, Davide Treggiari, Declan McLaughlin, Barbara McDermott, David J. Grieve, Ciaran McCarthy
Publikováno v:
Queen's University Belfast-PURE
The heart is subjected to oxidative stress in conditions of increased reactive oxygen species (ROS) production, such as doxorubicin (DOX) chemotherapy. A major cause of associated ventricular dysfunction is cardiomyocyte loss through apoptosis, while
Autor:
Pauline M. Rudd, Reinhold J. Medina, Carmel M. McVicar, Alan W. Stitt, Claire L. Kitson, Ross Hamilton, Jodie L. Abrahams, Tom A. Gardiner, Dash Durga, Liza Colhoun
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11870 (2010)
PLoS ONE
PLoS ONE
BackgroundErythropoiesis stimulating agents (ESAs) are widely used to treat anaemia but concerns exist about their potential to promote pathological angiogenesis in some clinical scenarios. In the current study we have assessed the angiogenic potenti