Výsledky vyhledávání - "Liz Svensson"

A phase Ia/Ib, dose-escalation/expansion study of BI 907828 in combination with BI 754091 (ezabenlimab) and BI 754111 in patients (pts) with advanced solid tumors

Autor: Noboru Yamamoto, Navid Hafez, Anthony W. Tolcher, Michael Teufel, Junxian Geng, Liz Svensson, Mehdi Lahmar, Mrinal M. Gounder

Publikováno v: Journal of Clinical Oncology. 40:3095-3095

3095 Background: Preclinical data show that combining a murine double minute 2–tumor protein 53 (MDM2–p53) antagonist with immune checkpoint inhibitors produces anti-tumor effects in multiple tumor types. This Phase Ia/Ib study (NCT03964233) is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::273f47695b07f514e0bf92ab5e69d278
https://doi.org/10.1200/jco.2022.40.16_suppl.3095

Zobrazit plný text záznamu

Afatinib versus methotrexate as second-line treatment in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck progressing on or after platinum-based therapy (LUX-HeadNeck 1): an open-label, randomised phase 3 trial

Publikováno v: The lancet oncology

Summary Background Patients with recurrent or metastatic squamous-cell carcinoma of the head and neck (HNSCC) progressing after first-line platinum regimens have a poor prognosis and few treatment options. Afatinib, an irreversible ERBB family blocke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f0f3cf72008e05696016698460ed1a
https://pubmed.ncbi.nlm.nih.gov/25940985

Zobrazit plný text záznamu

Fibromodulin and lumican bind to the same region on collagen type I fibrils

Autor: Liz Svensson, Ingmar Närlid, Åke Oldberg

Publikováno v: FEBS Letters. 470:178-182

Fibromodulin and lumican are closely related members of the extracellular matrix leucine-rich repeat glycoprotein/proteoglycan family. Similar to decorin, another member of this protein family, they bind to fibrillar collagens and function in the ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8911c368d8a2f6a4c59e9ce203834640
https://doi.org/10.1016/s0014-5793(00)01314-4

Zobrazit plný text záznamu

Cartilage oligomeric matrix protein-deficient mice have normal skeletal development

Autor: Finn P. Reinholt, Ernst B. Hunziker, Liz Svensson, Dick Heinegård, Reinhard Fässler, Attila Aszódi, Åke Oldberg

Publikováno v: Molecular and Cellular Biology; 22(12), pp 4366-4371 (2002)

Cartilage oligomeric matrix protein (COMP) belongs to the thrombospondin family and is a homopentamer primarily expressed in cartilage. Mutations in the COMP gene result in the autosomal dominant chondrodysplasias pseudoachondroplasia (PSACH) and som

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3fd551ab6e170001c4b0b8e347b54f0
https://lup.lub.lu.se/record/108431

Zobrazit plný text záznamu

Fibromodulin-null mice have abnormal collagen fibrils, tissue organization, and altered lumican deposition in tendon

Autor: Åke Oldberg, Attila Aszódi, Finn P. Reinholt, Reinhard Fässler, Liz Svensson, Dick Heinegård

Publikováno v: The Journal of biological chemistry. 274(14)

Fibromodulin is a member of a family of connective tissue glycoproteins/proteoglycans containing leucine-rich repeat motifs. Several members of this gene family bind to fibrillar collagens and are believed to function in the assembly of the collagen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a6aa2982f5cae1386bae60d6353cc2
https://pubmed.ncbi.nlm.nih.gov/10092650

Zobrazit plný text záznamu

Decorin-binding sites for collagen type I are mainly located in leucine-rich repeats 4-5

Autor: Åke Oldberg, Dick Heinegård, Liz Svensson

Publikováno v: The Journal of biological chemistry. 270(35)

Decorin and biglycan are structurally related interstitial proteoglycans synthesized in connective tissues like skin, tendon, and cartilage. Despite the conspicuous sequence similarities, where about 55% of the amino acid residues in decorin and bigl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4830ea7301bd970c67ac42f38d2e76
https://pubmed.ncbi.nlm.nih.gov/7657652

Zobrazit plný text záznamu

LUX-H&N 1: A phase III, randomized trial of afatinib versus methotrexate (MTX) in patients (pts) with recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) who progressed after platinum-based therapy

Autor: Lisa Licitra, Liz Svensson, Robert I. Haddad, Ezra E.W. Cohen, E. Ehrnrooth, Makoto Tahara, Jean-Pascal Machiels, X.J. Cong

Publikováno v: Journal of Clinical Oncology. 30:TPS5598-TPS5598

TPS5598 Background: EGFR (ErbB1) is expressed in 90% of HNSCC and associated with poor prognosis. Despite clinical benefit (CB) of EGFR-targeted treatments such as cetuximab treatment resistance will occur resulting in a need for novel targeted treat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c0e0349a8e3b8ebaa17fbb234505fec
https://doi.org/10.1200/jco.2012.30.15_suppl.tps5598

Zobrazit plný text záznamu

Collagen binding proteins

Autor: Liz Svensson, Dick Heinegård, Åke Oldberg

Publikováno v: Osteoarthritis and Cartilage. :S23-S28

The connective tissues are crucial for multicellular organisms, playing many diverse roles both structurally and mechanically as well as providing a protective function. They make up the frame of the mammalian body and add strength and elasticity, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a9575645e22de622c9dd9de3bd847a

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání