Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Liz Medcalf"'
Autor:
K. McLay, Richard Newton, L. Compston, Neil Bryant, Liz Medcalf, L. Clissold, D. Grafham, Andrew J. Davison, Gavin S. Wilkie, Colin A. Russell, Debra Elton
Publikováno v:
Transboundary and Emerging Diseases
Summary Equine herpesvirus 1 (EHV‐1) causes respiratory disease, abortion, neonatal death and neurological disease in equines and is endemic in most countries. The viral factors that influence EHV‐1 disease severity are poorly understood, and thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0804528aef43795c09cc3614b3eb6975
https://doi.org/10.1111/tbed.12809
https://doi.org/10.1111/tbed.12809
Publikováno v:
Elton, D, Amorim, M J, Medcalf, L & Digard, P 2005, ' 'Genome gating'; polarized intranuclear trafficking of influenza virus RNPs ', Biology letters, vol. 1, no. 2, pp. 113-7 . https://doi.org/10.1098/rsbl.2004.0253
Many viruses exploit cellular polarity to constrain the assembly and release of progeny virions to a desired surface. Influenza virus particles are released only from the apical surface of epithelial cells and this polarization is partly owing to spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8636e6aeea16aa897a4b43696b30d2b
https://doi.org/10.1098/rsbl.2004.0253
https://doi.org/10.1098/rsbl.2004.0253
Publikováno v:
Lee, M T, Bishop, K, Medcalf, L, Elton, D, Digard, P & Tiley, L 2002, ' Definition of the minimal viral components required for the initiation of unprimed RNA synthesis by influenza virus RNA polymerase ', Nucleic Acids Research, pp. 429-38 .
The first 11 nt at the 5' end of influenza virus genomic RNA were shown to be both necessary and sufficient for specific binding by the influenza virus polymerase. A novel in vitro transcription assay, in which the polymerase was bound to paramagneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7d6d1e10c98bfc4ea84a9455d09621
https://doi.org/10.1093/nar/30.2.429
https://doi.org/10.1093/nar/30.2.429
Publikováno v:
Europe PubMed Central
Medcalf, L, Poole, E, Elton, D & Digard, P 1999, ' Temperature-sensitive lesions in two influenza A viruses defective for replicative transcription disrupt RNA binding by the nucleoprotein ', Journal of Virology, vol. 73, no. 9, pp. 7349-56 . < http://jvi.asm.org/content/73/9/7349.long >
Medcalf, L, Poole, E, Elton, D & Digard, P 1999, ' Temperature-sensitive lesions in two influenza A viruses defective for replicative transcription disrupt RNA binding by the nucleoprotein ', Journal of Virology, vol. 73, no. 9, pp. 7349-56 . < http://jvi.asm.org/content/73/9/7349.long >
The negative-sense segmented RNA genome of influenza virus is transcribed into capped and polyadenylated mRNAs, as well as full-length replicative intermediates (cRNAs). The mechanism that regulates the two forms of transcription remains unclear, alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead52b17fa3927a3f325569c143b0850
https://doi.org/10.1128/jvi.73.9.7349-7356.1999
https://doi.org/10.1128/jvi.73.9.7349-7356.1999
Autor:
Emily A. Bruce, Liz Medcalf, Janet M. Daly, Helen M. Wise, Debra Elton, Adam Rash, Neil Bryant, Paul Digard, Matthew L. Turnbull, Nikki Smith, Shona MacRae
Publikováno v:
Elton, D, Bruce, E A, Bryant, N, Wise, H M, MacRae, S, Rash, A, Smith, N, Turnbull, M L, Medcalf, L, Daly, J M & Digard, P 2013, ' The genetics of virus particle shape in equine influenza A virus ', Influenza and other respiratory viruses, vol. 7, pp. 81-89 . https://doi.org/10.1111/irv.12197
Influenza and Other Respiratory Viruses
Influenza and Other Respiratory Viruses
Background: \ud Many human strains of influenza A virus produce highly pleomorphic virus particles that at the extremes can be approximated as either spheres of around 100 nm diameter or filaments of similar cross‐section but elongated to lengths o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6a582baac29e6536aee6ba0d32e9ef
Autor:
Liz Medcalf, John W. McCauley, Armando Damiani, Neil Bryant, Adam Rash, Donna Blinman, Janet M. Daly, Samantha Bowman, Sunitha Joseph, Alana Woodward, J. Richard Newton, Nicola S. Lewis, J. A. Mumford, Thomas M. Chambers, Ashish Tiwari, Debra Elton
Publikováno v:
Veterinary microbiology. 169(3-4)
Equine influenza viruses are a major cause of respiratory disease in horses worldwide and undergo antigenic drift. Several outbreaks of equine influenza occurred worldwide during 2010-2012, including in vaccinated animals, highlighting the importance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db65d906c12c5ace4b74406763d56f3
https://pubmed.ncbi.nlm.nih.gov/24480583
https://pubmed.ncbi.nlm.nih.gov/24480583
Autor:
Katherine Bowers, Sarah L. Noton, Paul Digard, Emily A. Bruce, Colin M. Crump, Debra Elton, Helen M. Wise, Liz Medcalf, Amanda D. Stuart
Publikováno v:
Bruce, E A, Medcalf, L, Crump, C M, Noton, S L, Stuart, A D, Wise, H M, Elton, D, Bowers, K & Digard, P 2009, ' Budding of filamentous and non-filamentous influenza A virus occurs via a VPS4 and VPS28-independent pathway ', Journal of Virology, vol. 390, no. 2, pp. 268-278 . https://doi.org/10.1016/j.virol.2009.05.016
The mechanism of membrane scission during influenza A virus budding has been the subject of controversy. We confirm that influenza M1 binds VPS28, a subunit of the ESCRT-1 complex. However, confocal microscopy of infected cells showed no marked coloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8edeecc22a523b86db44bcb171bd2e1
https://hdl.handle.net/20.500.11820/9bd02e43-20ed-4a6b-abf4-0e9da54a83c7
https://hdl.handle.net/20.500.11820/9bd02e43-20ed-4a6b-abf4-0e9da54a83c7
Publikováno v:
Traffic (Copenhagen, Denmark). 8(1)
Influenza A virus transcribes its segmented negative sense RNA genome in the nuclei of infected cells in a process long known to require host RNA polymerase II (RNAP-II). RNA polymerase II synthesizes pre-mRNAs whose 5'-cap structures are scavenged b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::868e5416c0f8bf15d96e9e670d3826f2
https://pubmed.ncbi.nlm.nih.gov/17132145
https://pubmed.ncbi.nlm.nih.gov/17132145
Autor:
Liz Medcalf, Kate Archer, Paul Digard, Debra Elton, John W. McCauley, Roger Hallam, Martha Simpson-Holley
Publikováno v:
Elton, D, Simpson-Holley, M, Archer, K, Medcalf, L, Hallam, R, McCauley, J & Digard, P 2001, ' Interaction of the influenza virus nucleoprotein with the cellular CRM1-mediated nuclear export pathway ', Journal of Virology, vol. 75, no. 1, pp. 408-19 .
Influenza virus transcription occurs in the nuclei of infected cells, where the viral genomic RNAs are complexed with a nucleoprotein (NP) to form ribonucleoprotein (RNP) structures. Prior to assembly into progeny virions, these RNPs exit the nucleus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1504af160394355d2b99700455ab9586
https://pubmed.ncbi.nlm.nih.gov/11119609
https://pubmed.ncbi.nlm.nih.gov/11119609
Autor:
Nicholas Coleman, Heather Griffin, Jane C. Sterling, Terence Prospero, John Doorbar, Charmaine Foo, Greg Winter, Oliver Hartley, Sawsan Napthine, Liz Medcalf
Publikováno v:
Virology. 238(1)
HPV late gene expression is initiated as an infected basal cell migrates through the differentiating layers of the epidermis, resulting in the onset of vegetative viral DNA replication and the expression of viral late proteins. We have used a large s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2dd1b42430effb38bc9a0d7c6455d8
https://pubmed.ncbi.nlm.nih.gov/9375007
https://pubmed.ncbi.nlm.nih.gov/9375007