Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Liz Flavell"'
Autor:
Sven Wernersson, Romel Bobby, Liz Flavell, Alexander G. Milbradt, Geoffrey A. Holdgate, Kevin J. Embrey, Mikael Akke
Publikováno v:
Biochemistry. 61:2303-2318
The bromodomain and extra-terminal (BET) protein BRD4 regulates gene expression via recruitment of transcriptional regulatory complexes to acetylated chromatin. Like other BET proteins, BRD4 contains two bromodomains, BD1 and BD2, that can interact c
Autor:
Liz Flavell
Teachers in both special and mainstream schools have to be confident in their abilities to implement inclusion effectively, in order for the child to have any chance of a successful inclusive school career. This book demonstrates how mainstream and s
Autor:
Liz Flavell, Jakub Luptak, David J. Hargreaves, Steven L. Kazmirski, Tina Howard, Kate F. Wickson, Ning Gao, David I Fisher, Michal Bista, Philip B. Rawlins
Publikováno v:
Acta Crystallographica. Section D, Structural Biology
Mcl-1 is an important cancer target for drug therapy, through which normal apoptosis may be restored by inhibiting its protective function. An scFv and a Fab have been used to generate an apo Mcl-1 crystal system that is amenable to iterative structu
Autor:
David Hargeaves, Elizabeth England, Robert M. Woods, Michael Fung, Caroline Colley, Paul Warrener, Liz Flavell, Sudharsan Sridharan, Judit E. Debreczeni, Jessica Bonnell, Claire Dobson, Jingying Zha, Bryan M. Edwards, Ling-Ling An, Laura Eghobamien, Ulf Sivars, Joanne Arnold, Jonathan Renshaw, Bojana Popovic, Kate F. Wickson, Tristan J. Vaughan, Trevor Wilkinson
Publikováno v:
mAbs
'mAbs ', vol: 10, pages: 104-117 (2018)
'mAbs ', vol: 10, pages: 104-117 (2018)
C5a is a potent anaphylatoxin that modulates inflammation through the C5aR1 and C5aR2 receptors. The molecular interactions between C5a–C5aR1 receptor are well defined, whereas C5a–C5aR2 receptor interactions are poorly understood. Here, we descr
Autor:
Dmitri I. Svergun, Huawei Chen, Romel Bobby, Natalie Stratton, Danette L. Daniels, Scott Boiko, Rowena Callis, Yi Yao, Graeme R. Robb, Alfred A. Rabow, Mark S. B. McAlister, Graeme Walker, Joe Patel, Matthew B. Robers, Derek Ogg, Sakina Saif, Liz Flavell, Philip Petteruti, Austin Dulak, Ian L. Dale, Jacqui Méndez, Thomas A. Jowitt, Michael J. Waring, David Matthew Wilson, David Whittaker, Wenxian Wang, Edwin Clark, Alexey Kikhney, Geoff Holdgate, Rob H. Bradbury
Publikováno v:
Nature Chemical Biology. 12:1097-1104
Proteins of the bromodomain and extraterminal (BET) family, in particular bromodomain-containing protein 4 (BRD4), are of great interest as biological targets. BET proteins contain two separate bromodomains, and existing inhibitors bind to them monov
Autor:
Kevin J. Embrey, Alexander L. Breeze, Uybach Vo, Liz Flavell, Romel Bobby, Navratna Vajpai, Alexander P. Golovanov
Publikováno v:
The Journal of Biological Chemistry
The activity of Ras is controlled by the interconversion between GTP- and GDP-bound forms partly regulated by the binding of the guanine nucleotide exchange factor Son of Sevenless (Sos). The details of Sos binding, leading to nucleotide exchange and
Autor:
Dorothy A. Sims, Richard D. May, Tomas Mustelin, Joanne Woods, David C. Lowe, Denice T. Y. Chan, Laura Rapley, Benjamin Kemp, Matthew A. Sleeman, Nicholas J. Bond, Christel Séguy Veyssier, Liz Flavell, Katherine A. Vousden, Tristan J. Vaughan, Sara Carmen, Kevin J. Embrey, Overed-Sayer Catherine L, Catherine E. Huntington, Christopher E. Brightling, Michael R. Snaith, Bojana Popovic, D. Gareth Rees, Strain Martin D, Ian C. Scott, E. Suzanne Cohen, Jianqing Xu, Dominic J. Corkill, Jayesh B. Majithiya, Daniel R. Higazi, Elizabeth England, Robin Butler
Publikováno v:
Nature Communications
In response to infections and irritants, the respiratory epithelium releases the alarmin interleukin (IL)-33 to elicit a rapid immune response. However, little is known about the regulation of IL-33 following its release. Here we report that the biol
Autor:
Leen J M Seys, Bart N. Lambrecht, Ken R. Bracke, Ronald Herbst, Eileen McCall, Claudie Bantsimba-Malanda, Sharen Provoost, Danen Cunoosamy, Anja Schinwald, Guy Brusselle, Hamida Hammad, Guy Joos, Alan Sabirsh, Fien M. Verhamme, Liz Flavell
Publikováno v:
American journal of respiratory and critical care medicine. 192(6)
B cell-activating factor (BAFF) plays a major role in activation of B cells and in adaptive humoral immune responses. In chronic obstructive pulmonary disease (COPD), lymphoid follicles have been associated with disease severity, and overexpression o
Autor:
Liz Flavell
Publikováno v:
Preparing to Include Special Children in Mainstream Schools ISBN: 9781315069357
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a772d861e939611575255248fff49fb6
https://doi.org/10.4324/9781315069357-11
https://doi.org/10.4324/9781315069357-11