JUNB O-GlcNAcylation-Mediated Promoter Accessibility of Metabolic Genes Modulates Distinct Epithelial Lineage in Pulmonary Fibrosis.

Autor: Bammert MT; Lung Repair & Regeneration Department, Boehringer Ingelheim Pharma GmbH & Co. KG, 88400, Biberach, Germany.; Faculty of Biology, University of Konstanz, 78457, Konstanz, Germany., Ansari M; Global Computational Biology and Digital Science, Boehringer Ingelheim Pharma GmbH & Co. KG, 88400, Biberach, Germany., Haag L; Lung Repair & Regeneration Department, Boehringer Ingelheim Pharma GmbH & Co. KG, 88400, Biberach, Germany., Ahmad Z; Lung Repair & Regeneration Department, Boehringer Ingelheim Pharma GmbH & Co. KG, 88400, Biberach, Germany., Schröder V; Lung Repair & Regeneration Department, Boehringer Ingelheim Pharma GmbH & Co. KG, 88400, Biberach, Germany., Birch J; Lung Repair & Regeneration Department, Boehringer Ingelheim Pharma GmbH & Co. KG, 88400, Biberach, Germany., Santacruz D; Global Computational Biology and Digital Science, Boehringer Ingelheim Pharma GmbH & Co. KG, 88400, Biberach, Germany., Rust W; Global Computational Biology and Digital Science, Boehringer Ingelheim Pharma GmbH & Co. KG, 88400, Biberach, Germany., Viollet C; Global Computational Biology and Digital Science, Boehringer Ingelheim Pharma GmbH & Co. KG, 88400, Biberach, Germany., Strobel B; Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, 88400, Biberach, Germany., Dick A; Global Computational Biology and Digital Science, Boehringer Ingelheim Pharma GmbH & Co. KG, 88400, Biberach, Germany., Gantner F; Faculty of Biology, University of Konstanz, 78457, Konstanz, Germany.; C.H. Boehringer Sohn AG and Co. KG, 55218, Ingelheim, Germany., Schlüter H; Lung Repair & Regeneration Department, Boehringer Ingelheim Pharma GmbH & Co. KG, 88400, Biberach, Germany., Ramirez F; Global Computational Biology and Digital Science, Boehringer Ingelheim Pharma GmbH & Co. KG, 88400, Biberach, Germany., Lizé M; Lung Repair & Regeneration Department, Boehringer Ingelheim Pharma GmbH & Co. KG, 88400, Biberach, Germany., Thomas MJ; Lung Repair & Regeneration Department, Boehringer Ingelheim Pharma GmbH & Co. KG, 88400, Biberach, Germany.; University of Bath, Bath, BA27JX, UK., Le HQ; Lung Repair & Regeneration Department, Boehringer Ingelheim Pharma GmbH & Co. KG, 88400, Biberach, Germany.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Dec 15, pp. e2406751. Date of Electronic Publication: 2024 Dec 15.

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Transcription factor TAp73 and microRNA-449 complement each other to support multiciliogenesis.

Autor: Wildung M; Molecular & Experimental Pneumology Group, Clinic for Cardiology and Pneumology, University Medical Center Goettingen, Goettingen, Germany., Esser TU; Molecular & Experimental Pneumology Group, Clinic for Cardiology and Pneumology, University Medical Center Goettingen, Goettingen, Germany., Grausam KB; Cancer Biology and Immunotherapeutics Group, Sanford Research, Sioux Falls, SD, USA.; Division of Basic Biomedical Sciences, University of South Dakota, Sanford School of Medicine, Vermillion, SD, USA., Wiedwald C; Molecular & Experimental Pneumology Group, Clinic for Cardiology and Pneumology, University Medical Center Goettingen, Goettingen, Germany., Volceanov-Hahn L; Molecular & Experimental Pneumology Group, Clinic for Cardiology and Pneumology, University Medical Center Goettingen, Goettingen, Germany., Riedel D; Electron Microscopy, Max-Planck-Institute for Biophysical Chemistry, Goettingen, Germany., Beuermann S; Molecular & Experimental Pneumology Group, Clinic for Cardiology and Pneumology, University Medical Center Goettingen, Goettingen, Germany., Li L; Cancer Biology and Immunotherapeutics Group, Sanford Research, Sioux Falls, SD, USA., Zylla J; Cancer Biology and Immunotherapeutics Group, Sanford Research, Sioux Falls, SD, USA., Guenther AK; Department of Genes and Behavior, MPI for Biophysical Chemistry, Goettingen, Germany., Wienken M; Institute of Molecular Oncology, University Medical Center Goettingen, Goettingen, Germany., Ercetin E; Molecular & Experimental Pneumology Group, Clinic for Cardiology and Pneumology, University Medical Center Goettingen, Goettingen, Germany., Han Z; Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY, USA., Bremmer F; Institute of Pathology, University Medical Center Goettingen, Goettingen, Germany., Shomroni O; Microarray and Deep-Sequencing Core Facility, University Medical Center Goettingen, Goettingen, Germany., Andreas S; Molecular & Experimental Pneumology Group, Clinic for Cardiology and Pneumology, University Medical Center Goettingen, Goettingen, Germany., Zhao H; Cancer Biology and Immunotherapeutics Group, Sanford Research, Sioux Falls, SD, USA. hzhao10@nyit.edu.; Division of Basic Biomedical Sciences, University of South Dakota, Sanford School of Medicine, Vermillion, SD, USA. hzhao10@nyit.edu.; Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY, USA. hzhao10@nyit.edu., Lizé M; Molecular & Experimental Pneumology Group, Clinic for Cardiology and Pneumology, University Medical Center Goettingen, Goettingen, Germany. mlize@gwdg.de.

Publikováno v: Cell death and differentiation [Cell Death Differ] 2019 Dec; Vol. 26 (12), pp. 2740-2757. Date of Electronic Publication: 2019 May 08.

miR449 Protects Airway Regeneration by Controlling AURKA/HDAC6-Mediated Ciliary Disassembly.

Autor: Wildung M; Molecular & Experimental Pneumology Group, Clinic for Cardiology and Pneumology, University Medical Center Goettingen, 37075 Gottingen, Germany.; Molecular Oncology, University Medical Center Goettingen, 37077 Goettingen, Germany., Herr C; Department of Internal Medicine V, Saarland University, 66421 Homburg, Germany., Riedel D; Laboratory for Electron Microscopy, Max Planck Institute for Multidisciplinary Sciences, 37075 Goettingen, Germany., Wiedwald C; Molecular & Experimental Pneumology Group, Clinic for Cardiology and Pneumology, University Medical Center Goettingen, 37075 Gottingen, Germany.; Molecular Oncology, University Medical Center Goettingen, 37077 Goettingen, Germany., Moiseenko A; Immunology & Respiratory Department, Boehringer Ingelheim Pharma GmbH, 88400 Biberach an der Riss, Germany., Ramírez F; Global Computational Biology and Digital Sciences Department, Boehringer Ingelheim Pharma GmbH, 88400 Biberach an der Riss, Germany., Tasena H; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9712 Groningen, The Netherlands.; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, 9712 Groningen, The Netherlands., Heimerl M; Molecular & Experimental Pneumology Group, Clinic for Cardiology and Pneumology, University Medical Center Goettingen, 37075 Gottingen, Germany.; Molecular Oncology, University Medical Center Goettingen, 37077 Goettingen, Germany., Alevra M; Institute of Neuro- and Sensory Physiology, Goettingen University, 37073 Goettingen, Germany., Movsisyan N; Oncophysiology Group, Max Planck Institute for Multidisciplinary Sciences, 37075 Goettingen, Germany., Schuldt M; Molecular Oncology, University Medical Center Goettingen, 37077 Goettingen, Germany., Volceanov-Hahn L; Molecular & Experimental Pneumology Group, Clinic for Cardiology and Pneumology, University Medical Center Goettingen, 37075 Gottingen, Germany., Provoost S; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, 9000 Ghent, Belgium., Nöthe-Menchen T; Department of General Pediatrics, University Hospital Muenster, 48149 Muenster, Germany., Urrego D; Oncophysiology Group, Max Planck Institute for Multidisciplinary Sciences, 37075 Goettingen, Germany., Freytag B; Molecular Oncology, University Medical Center Goettingen, 37077 Goettingen, Germany., Wallmeier J; Department of General Pediatrics, University Hospital Muenster, 48149 Muenster, Germany., Beisswenger C; Department of Internal Medicine V, Saarland University, 66421 Homburg, Germany., Bals R; Department of Internal Medicine V, Saarland University, 66421 Homburg, Germany., van den Berge M; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, 9712 Groningen, The Netherlands.; Department of Pulmonology, University Medical Center Groningen, University of Groningen, 9712 Groningen, The Netherlands., Timens W; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9712 Groningen, The Netherlands.; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, 9712 Groningen, The Netherlands., Hiemstra PS; Department of Pulmonology, Leiden University Medical Centre, 2333 Leiden, The Netherlands., Brandsma CA; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9712 Groningen, The Netherlands.; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, 9712 Groningen, The Netherlands., Maes T; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, 9000 Ghent, Belgium., Andreas S; Molecular & Experimental Pneumology Group, Clinic for Cardiology and Pneumology, University Medical Center Goettingen, 37075 Gottingen, Germany., Heijink IH; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9712 Groningen, The Netherlands.; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, 9712 Groningen, The Netherlands.; Department of Pulmonology, University Medical Center Groningen, University of Groningen, 9712 Groningen, The Netherlands., Pardo LA; Oncophysiology Group, Max Planck Institute for Multidisciplinary Sciences, 37075 Goettingen, Germany., Lizé M; Molecular & Experimental Pneumology Group, Clinic for Cardiology and Pneumology, University Medical Center Goettingen, 37075 Gottingen, Germany.; Molecular Oncology, University Medical Center Goettingen, 37077 Goettingen, Germany.; Immunology & Respiratory Department, Boehringer Ingelheim Pharma GmbH, 88400 Biberach an der Riss, Germany.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Jul 13; Vol. 23 (14). Date of Electronic Publication: 2022 Jul 13.