Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Liz, Bentley"'
Autor:
Luis C. Fernández-Beltrán, Zeinab Ali, Angélica Larrad-Sanz, Juan I. Lopez-Carbonero, Juan M. Godoy-Corchuelo, Irene Jimenez-Coca, Irene Garcia-Toledo, Liz Bentley, Ulises Gomez-Pinedo, Jordi A. Matias-Guiu, Maria Jose Gil-Moreno, Jorge Matias-Guiu, Silvia Corrochano
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by significant metabolic disruptions, including weight loss and hypermetabolism in both patients and animal models. Leptin, an adipose-derived hormone, d
Externí odkaz:
https://doaj.org/article/613bb86953c84237ad953fb63e5bb4f0
Autor:
Milan Mušo, Liz Bentley, Lucie Vizor, Marianne Yon, Keith Burling, Peter Barker, Louisa A. K. Zolkiewski, Roger D. Cox, Rebecca Dumbell
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Background: Increased waist-to-hip ratio (WHR) is associated with increased mortality and risk of type 2 diabetes and cardiovascular disease. The TBX15-WARS2 locus has consistently been associated with increased WHR. Previous study of the hypomorphic
Externí odkaz:
https://doaj.org/article/f7c60682630f43f89e23e3177f7a517a
Publikováno v:
Biology Open, Vol 10, Iss 12 (2021)
The small GTPase ARF family member ARL15 gene locus is associated in population studies with increased risk of type 2 diabetes, lower adiponectin and higher fasting insulin levels. Previously, loss of ARL15 was shown to reduce insulin secretion in a
Externí odkaz:
https://doaj.org/article/e5a87e8d34b74befb9f2fc9a9ea03077
Autor:
Sian E. Piret, Eric Olinger, Anita A. C. Reed, M. Andrew Nesbit, Tertius A. Hough, Liz Bentley, Olivier Devuyst, Roger D. Cox, Rajesh V. Thakker
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 6, Pp 773-786 (2017)
Renal fibrosis is a common feature of renal failure resulting from multiple etiologies, including diabetic nephropathy, hypertension and inherited renal disorders. However, the mechanisms of renal fibrosis are incompletely understood and we therefore
Externí odkaz:
https://doaj.org/article/c0c096b86bf144ef9707f9184689718e
Autor:
Laura L Gathercole, Nikolaos Nikolaou, Shelley E Harris, Anastasia Arvaniti, Toryn M Poolman, Jonathan M Hazlehurst, Denise V Kratschmar, Marijana Todorčević, Ahmad Moolla, Niall Dempster, Ryan C Pink, Michael F Saikali, Liz Bentley, Trevor M Penning, Claes Ohlsson, Carolyn L Cummins, Matti Poutanen, Alex Odermatt, Roger D Cox, Jeremy W Tomlinson
Publikováno v:
Journal of Endocrinology. 253:97-113
Steroid 5β-reductase (AKR1D1) plays important role in hepatic bile acid synthesis and glucocorticoid clearance. Bile acids and glucocorticoids are potent metabolic regulators, but whether AKR1D1 controls metabolic phenotype in vivo is unknown. Akr1d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de9778b5b1fbb3dbdd7f97861c4fc255
https://doi.org/10.1530/joe-21-0280
https://doi.org/10.1530/joe-21-0280
Correction: Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons.
Autor:
Naila Haq, Christoph Schmidt-Hieber, Fernando J Sialana, Lorenza Ciani, Janosch P Heller, Michelle Stewart, Liz Bentley, Sara Wells, Richard J Rodenburg, Patrick M Nolan, Elizabeth Forsythe, Michael C Wu, Gert Lubec, Patricia C Salinas, Michael Häusser, Philip L Beales, Sofia Christou-Savina
Publikováno v:
PLoS Biology, Vol 17, Iss 10, p e3000520 (2019)
[This corrects the article DOI: 10.1371/journal.pbio.3000414.].
Externí odkaz:
https://doaj.org/article/e9e4591deded4a4d8c04f40819a54f18
Autor:
Naila Haq, Christoph Schmidt-Hieber, Fernando J Sialana, Lorenza Ciani, Janosch P Heller, Michelle Stewart, Liz Bentley, Sara Wells, Richard J Rodenburg, Patrick M Nolan, Elizabeth Forsythe, Michael C Wu, Gert Lubec, P Salinas, Michael Häusser, Philip L Beales, Sofia Christou-Savina
Publikováno v:
PLoS Biology, Vol 17, Iss 9, p e3000414 (2019)
Bardet-Biedl syndrome (BBS), a ciliopathy, is a rare genetic condition characterised by retinal degeneration, obesity, kidney failure, and cognitive impairment. In spite of progress made in our general understanding of BBS aetiology, the molecular an
Externí odkaz:
https://doaj.org/article/476db0f2540d4ebfa5d72cbe98ee01fd
Autor:
Thomas Agnew, Michelle Goldsworthy, Carlos Aguilar, Anna Morgan, Michelle Simon, Helen Hilton, Chris Esapa, Yixing Wu, Heather Cater, Liz Bentley, Cheryl Scudamore, Joanna Poulton, Karl J. Morten, Kyle Thompson, Langping He, Steve D.M. Brown, Robert W. Taylor, Michael R. Bowl, Roger D. Cox
Publikováno v:
Cell Reports, Vol 25, Iss 12, Pp 3315-3328.e6 (2018)
Summary: Mutations in genes essential for mitochondrial function have pleiotropic effects. The mechanisms underlying these traits yield insights into metabolic homeostasis and potential therapies. Here we report the characterization of a mouse model
Externí odkaz:
https://doaj.org/article/630a0a3d696840bfb3f385b49f594bbc
Loss of arylformamidase with reduced thymidine kinase expression leads to impaired glucose tolerance
Autor:
Alison J. Hugill, Michelle E. Stewart, Marianne A. Yon, Fay Probert, I. Jane Cox, Tertius A. Hough, Cheryl L. Scudamore, Liz Bentley, Gary Wall, Sara E. Wells, Roger D. Cox
Publikováno v:
Biology Open, Vol 4, Iss 11, Pp 1367-1375 (2015)
Tryptophan metabolites have been linked in observational studies with type 2 diabetes, cognitive disorders, inflammation and immune system regulation. A rate-limiting enzyme in tryptophan conversion is arylformamidase (Afmid), and a double knockout o
Externí odkaz:
https://doaj.org/article/0d46b7420e604bf78174db331289ed60
Autor:
Liz Bentley
Over recent years there has been a growing demand for climate education in schools and colleges. There is an aspiration that all children leave school climate literate so they can engage with the climate conversation and make informed decisions about
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58354313eafec4a00b181516deb2685f
https://doi.org/10.5194/ems2022-720
https://doi.org/10.5194/ems2022-720
