Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Liyuan, Le"'
1
Akademický článek
Pharmacological inhibition of BAP1 recruits HERC2 to competitively dissociate BRCA1–BARD1, suppresses DNA repair and sensitizes CRC to radiotherapy
Autor: Xin Yue, Tingyu Liu, Xuecen Wang, Weijian Wu, Gesi Wen, Yang Yi, Jiaxin Wu, Ziyang Wang, Weixiang Zhan, Ruirui Wu, Yuan Meng, Zhirui Cao, Liyuan Le, Wenyan Qiu, Xiaoyue Zhang, Zhenyu Li, Yong Chen, Guohui Wan, Xianzhang Bu, Zhenwei Peng, Ran-yi Liu
Publikováno v: Acta Pharmaceutica Sinica B, Vol 13, Iss 8, Pp 3382-3399 (2023)
Radiotherapy is widely used in the management of advanced colorectal cancer (CRC). However, the clinical efficacy is limited by the safe irradiated dose. Sensitizing tumor cells to radiotherapy via interrupting DNA repair is a promising approach to c
Externí odkaz: https://doaj.org/article/8ccb9288afe54949a3329ce24041a1b9
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2
Akademický článek
Stabilization of DEPTOR sensitizes hypopharyngeal cancer to radiotherapy via targeting degradation
Autor: Xuecen Wang, Zhirui Cao, Xin Yue, Tingyu Liu, Gesi Wen, Dongmei Jiang, Weijian Wu, Liyuan Le, Yan Wang, Chengtao Wang, Ziyang Wang, Meng Jin, Meiyan Zhu, Shasha He, Xiaoyue Zhang, Xianzhang Bu, Ran-yi Liu, Zhenwei Peng, Yong Chen
Publikováno v: Molecular Therapy: Oncolytics, Vol 26, Iss , Pp 330-346 (2022)
The use of radiotherapy for hypopharyngeal cancer (HC) treatment is increasing, and it is currently the primary treatment option for this cancer. However, radioresistance occurs in a proportion of patients. Here, we found that radiation increased pro
Externí odkaz: https://doaj.org/article/7f90ab44fd364cda869cbd9ab03bc3be
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8
Copper-Catalyzed Amination of C(sp3)–H bonds: From Anilides to Indolines
Autor: Nobuaki Kambe, Long Jinguo, Liyuan Le, Renhua Qiu, Takanori Iwasaki
Publikováno v: The Journal of Organic Chemistry. 85:482-492
Copper-catalyzed oxidative intramolecular cyclization of o-alkylated anilines via cleavage of C(sp3)-H and N-H bonds for the production of indolines is described. This approach provides a straightforward strategy for the synthesis of nitrogen-contain
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15c1f0c9b381c354d85c5d60ee3a2f3d
https://doi.org/10.1021/acs.joc.9b02404
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9
Carbon–Carbon Bond Formation of Trifluoroacetyl Amides with Grignard Reagents via C(O)–CF3 Bond Cleavage
Autor: Renhua Qiu, Nobuaki Kambe, Liyuan Le, Longzhi Zhu, Mingpan Yan, Chak-Tong Au
Publikováno v: The Journal of Organic Chemistry. 84:5635-5644
The reaction of trifluoroacetyl amides with Grignard reagent for the substitution of CF3 group with various alkyl or aryl groups is described. A variety of aryl, quinolin-8-yl, and (hetero)alkyl functional groups as well as F, Cl, and Br atoms are we
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c718c4208ce20fa6f4ac8fcfe6763552
https://doi.org/10.1021/acs.joc.9b00583
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