Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Liya Gebreab"'
Autor:
Rahul Kumar, Claudia Mickael, Biruk Kassa, Liya Gebreab, Jeffrey C. Robinson, Daniel E. Koyanagi, Linda Sanders, Lea Barthel, Christina Meadows, Daniel Fox, David Irwin, Min Li, B. Alexandre McKeon, Suzette Riddle, R. Dale Brown, Leslie E. Morgan, Christopher M. Evans, Daniel Hernandez-Saavedra, Angela Bandeira, James P. Maloney, Todd M. Bull, William J. Janssen, Kurt R. Stenmark, Rubin M. Tuder, Brian B. Graham
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Thrombospondin-1 (TSP-1) activates latent TGF-β in the extracellular matrix. Here the authors show that inappropriate activation of latent TGF-β in murine, bovine and human lung by monocyte-produced TSP-1 causes pulmonary hypertension, and that int
Externí odkaz:
https://doaj.org/article/12cae9f76300462c9772bdd1e67bd44a
Autor:
Kewal Asosingh, Nicholas Wanner, Kelly Weiss, Kimberly Queisser, Liya Gebreab, Biruk Kassa, Eric Stuehr, Brian Graham, Serpil Erzurum
Publikováno v:
Blood Advances, Vol 1, Iss 9, Pp 526-534 (2017)
Abstract: Accumulating evidence shows a causative role for the bone marrow (BM) in the genesis and progression of pulmonary hypertension (PH). Engraftment of BM hematopoietic stem cells from PH patients to mice reproduces the cardiopulmonary patholog
Externí odkaz:
https://doaj.org/article/4a4a4dc9eaeb48588de57f50d69db1df
Autor:
Rajesh Kumar, Alexandra Rodriguez Garcia, William J. Janssen, Lea Barthel, Linda Sanders, Brian B. Graham, Daniel E. Koyanagi, Liya Gebreab, Thais Mauad, Rubin M. Tuder, Angela Bandeira, Claudia Mickael, Mark T. Kearns, Aneta Gandjeva, Eric P. Schmidt, Jacob J. Chabon, Alleluiah Rutebemberwa
Publikováno v:
American journal of respiratory and critical care medicine, vol 192, iss 8
RationaleThe etiology of schistosomiasis-associated pulmonary arterial hypertension (PAH), a major cause of PAH worldwide, is poorly understood. Schistosoma mansoni exposure results in prototypical type-2 inflammation. Furthermore, transforming growt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963a890e5184ab835b94e0906aab99f3
https://doi.org/10.1164/rccm.201410-1820oc
https://doi.org/10.1164/rccm.201410-1820oc
Autor:
Daniel Hernandez-Saavedra, Rubin M. Tuder, R. Dale Brown, James P. Maloney, Angela Bandeira, Suzette R. Riddle, B. Alexandre McKeon, Lea Barthel, Christina Meadows, Jeffrey C. Robinson, Brian B. Graham, Rajesh Kumar, Todd M. Bull, Liya Gebreab, Linda Sanders, Kurt R. Stenmark, Claudia Mickael, Daniel L. Fox, Leslie E. Morgan, Daniel E. Koyanagi, David Irwin, Biruk Kassa, Christopher M. Evans, William J. Janssen, Min Li
Publikováno v:
Nature communications, vol 8, iss 1
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications
Pulmonary arterial hypertension (PAH) is an obstructive disease of the precapillary pulmonary arteries. Schistosomiasis-associated PAH shares altered vascular TGF-β signalling with idiopathic, heritable and autoimmune-associated etiologies; moreover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768240ee00e1b51d2a84960a799e215b
https://escholarship.org/uc/item/1108505b
https://escholarship.org/uc/item/1108505b
Autor:
Brian B. Graham, Katrina Diener, Liya Gebreab, Ewa Kolosionek, Michael G. Edwards, Ted Shade, Jacob J. Chabon, Kenneth L. Jones, Ghazwan Butrous, Rajesh Kumar, Elias Debella, Angela Bandeira, Mark W. Geraci, Rubin M. Tuder, Gao Bi-feng
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:951-959
Schistosomiasis is one of the most common causes of pulmonary arterial hypertension worldwide, but the pathogenic mechanism by which the host inflammatory response contributes to vascular remodeling is unknown. We sought to identify signaling pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d46a689996dcd965e4e1b9280a54aa
https://doi.org/10.1165/rcmb.2012-0532oc
https://doi.org/10.1165/rcmb.2012-0532oc
Autor:
Kewal, Asosingh, Nicholas, Wanner, Kelly, Weiss, Kimberly, Queisser, Liya, Gebreab, Biruk, Kassa, Eric, Stuehr, Brian, Graham, Serpil, Erzurum
Publikováno v:
Blood advances. 1(9)
Accumulating evidence shows a causative role for the bone marrow (BM) in the genesis and progression of pulmonary hypertension (PH). Engraftment of BM hematopoietic stem cells from PH patients to mice reproduces the cardiopulmonary pathology of PH. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f86f687a17bf57806e8f2e7821a036b5
https://pubmed.ncbi.nlm.nih.gov/29296972
https://pubmed.ncbi.nlm.nih.gov/29296972
Autor:
Brian B. Graham, Liya Gebreab, Mario J. Perez, Rajesh Kumar, Peter Smith-Jones, Kendra M. Huber, Linda Sanders, Claudia Mickael, Natalie J. Serkova, Rubin M. Tuder
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 309(5)
In severe pulmonary hypertension (SPH), prior studies have shown an increase in right ventricle (RV) uptake of glucose, but it is unclear whether there is a change in the relative utilization of fatty acids. We hypothesized that in the RV in SPH, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640211880a40df7f6f298f1e9a2a9ba4
https://pubmed.ncbi.nlm.nih.gov/26115672
https://pubmed.ncbi.nlm.nih.gov/26115672
Autor:
Takeshi Tanaka, Brian B. Graham, Liya Gebreab, Mario J. Perez, Jacob J. Chabon, Alexandra Rodriguez Garcia, Linda Sanders, Rajesh Kumar, Elias Debella, Dan Koyanagi, Rubin M. Tuder
Publikováno v:
Pulmonary circulation, vol 4, iss 2
There is significant evidence that Th2 (T helper 2)-mediated inflammation supports the pathogenesis of both human and experimental animal models of pulmonary hypertension (PH). A key immune regulator is vascular endothelial growth factor (VEGF), whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1a5c4e3b3eaa4534892ec2cc796fd8d
https://europepmc.org/articles/PMC4070790/
https://europepmc.org/articles/PMC4070790/
Autor:
Brian B. Graham, Rajesh Kumar, Liya Gebreab, Jacob Chabon, Rubin M. Tuder, Dan Koyanangi, Linda Sanders, Alexandra Rodriguez Garcia
Publikováno v:
The FASEB Journal. 28
Background: Schistosomiasis-associated pulmonary arterial hypertension (PAH) occurs in the context of Th2 inflammation, which is induced by IL-4 and IL-13. We had previously observed that TGF-β sig...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0d9c75e73f94632aa2d63d4cd6d4ba5
https://doi.org/10.1096/fasebj.28.1_supplement.lb780
https://doi.org/10.1096/fasebj.28.1_supplement.lb780