Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Lixin Rui"'
Autor:
Yuxuan Che, Yang Liu, Yixin Yao, Holly A. Hill, Yijing Li, Qingsong Cai, Fangfang Yan, Preetesh Jain, Wei Wang, Lixin Rui, Michael Wang
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Constant challenges for the treatment of mantle cell lymphoma (MCL) remain to be recurrent relapses and therapy resistance, especially in patients harboring somatic mutations in the tumor suppressors ATM and TP53, which are accumulated as th
Externí odkaz:
https://doaj.org/article/fbb3a5f3c243463abe3db9248e6b5800
Autor:
Fen Zhu, Jennifer L. Crombie, Wei Ni, Nguyet-Minh Hoang, Swati Garg, Liam Hackett, Stephen J. F. Chong, Mary C. Collins, Lixin Rui, James Griffin, Matthew S. Davids
Publikováno v:
Haematologica, Vol 109, Iss 1 (2023)
Despite recent advances in the therapy of diffuse large B-cell lymphoma (DLBCL), many patients are still not cured. Therefore, new therapeutic strategies are needed. The anti-apoptotic B-cell lymphoma 2 (BCL2) gene is commonly dysregulated in DLBCL d
Externí odkaz:
https://doaj.org/article/8b0191ebd1284f62ab563c4cfef6f73e
Autor:
Etienne Masle-Farquhar, Amanda Russell, Yangguang Li, Fen Zhu, Lixin Rui, Robert Brink, Christopher C Goodnow
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0237830 (2021)
Regulation of the anti-apoptotic BCL2 protein determines cell survival and is frequently abnormal in B cell lymphomas. An evolutionarily conserved post-translational mechanism for over-expression of BCL2 in human B cell lymphomas and the BCL2 paralog
Externí odkaz:
https://doaj.org/article/a946d24bae674a179a10e80799b88b0d
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127243 (2015)
Signal transducer and activator of transcription 3 (STAT3) is a key mediator of leukocyte differentiation and proliferation. The 3' end of STAT3 transcripts is subject to two alternative splicing events. One results in either full-length STAT3α or i
Externí odkaz:
https://doaj.org/article/4fa49790f0894ef6988cf838f88e51a8
Autor:
Lixin Rui, Christian M. Capitini, Thomas A. Waldmann, Madelyn Chen, Samantha Bebel, Apoorv Kondapelli, Alexander Rosiejka, Yangguang Li, Yunxia Liu, Amanda Kelm, David T. Yang, Shanxiang Zhang, Anusara Daenthanasanmak, Paul D. Bates, Fen Zhu, Nguyet M. Hoang, Li Lu, Shuichi Kimpara
Early growth response gene (EGR1) is a transcription factor known to be a downstream effector of B-cell receptor signaling and Janus kinase 1 (JAK1) signaling in diffuse large B-cell lymphoma (DLBCL). While EGR1 is characterized as a tumor suppressor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7fc4f731aa0924678a485fd314a9541
https://doi.org/10.1158/1541-7786.c.6545306.v1
https://doi.org/10.1158/1541-7786.c.6545306.v1
Autor:
Lixin Rui, Christian M. Capitini, Thomas A. Waldmann, Madelyn Chen, Samantha Bebel, Apoorv Kondapelli, Alexander Rosiejka, Yangguang Li, Yunxia Liu, Amanda Kelm, David T. Yang, Shanxiang Zhang, Anusara Daenthanasanmak, Paul D. Bates, Fen Zhu, Nguyet M. Hoang, Li Lu, Shuichi Kimpara
Supplementary Table S1 including analyzed RNA-seq and ChIP-seq data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e067120d4d6228b04ec19938a9eaf06
https://doi.org/10.1158/1541-7786.22527050
https://doi.org/10.1158/1541-7786.22527050
Autor:
Lixin Rui, Christian M. Capitini, Thomas A. Waldmann, Madelyn Chen, Samantha Bebel, Apoorv Kondapelli, Alexander Rosiejka, Yangguang Li, Yunxia Liu, Amanda Kelm, David T. Yang, Shanxiang Zhang, Anusara Daenthanasanmak, Paul D. Bates, Fen Zhu, Nguyet M. Hoang, Li Lu, Shuichi Kimpara
Supplementary Methods, Supplementary Figures and Figure Legends. Figure S1. EGR1 is a downstream target of BCR and JAK1 signaling (related to Figure 1). Figure S2. Sensitivity of MCL cell lines to EGR1 shRNAs and statistical analysis (related to Figu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3090fbe8e8e01eb05a340f7ecd43dd
https://doi.org/10.1158/1541-7786.22527053
https://doi.org/10.1158/1541-7786.22527053
BAF155 methylation drives metastasis by hijacking super-enhancers and subverting anti-tumor immunity
Autor:
Eui-Jun Kim, Peng Liu, Shengjie Zhang, Kristine Donahue, Yidan Wang, Jennifer L Schehr, Serena K Wolfe, Amber Dickerson, Li Lu, Lixin Rui, Xuehua Zhong, Kari B Wisinski, Min Yu, Aussie Suzuki, Joshua M Lang, Irene M Ong, Wei Xu
Publikováno v:
Nucleic Acids Research
Subunits of the chromatin remodeler SWI/SNF are the most frequently disrupted genes in cancer. However, how post-translational modifications (PTM) of SWI/SNF subunits elicit epigenetic dysfunction remains unknown. Arginine-methylation of BAF155 by co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ad4b52d40931fb38dac34b675c9123
http://europepmc.org/articles/PMC8643633
http://europepmc.org/articles/PMC8643633
Autor:
David P Turicek, Christian M. Capitini, Tara B. Gavcovich, Nicholas J Hess, Monica M. Cho, Lixin Rui, Fen Zhu, Sean P Rinella, Sabrina A. Kabakov, Kirsti L. Walker, Myriam N. Bouchlaka, Arika Feils, Sydney L. Olson, Aicha E. Quamine
Publikováno v:
Leuk Lymphoma
Relapsed/refractory T cell acute lymphoblastic leukemia (T-ALL) is difficult to salvage especially in heavily pretreated patients, thus novel targeted agents are sorely needed. Hyperactivated JAK/STAT and BCL2 overexpression promote increased T-ALL p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a155f88cbce1c89a4dea03157d83d0
https://doi.org/10.1080/10428194.2021.1910684
https://doi.org/10.1080/10428194.2021.1910684
Autor:
Nguyet-Minh Hoang, Lixin Rui
Publikováno v:
J Genet Genomics
DNA methyltransferases (DNMTs) are an evolutionarily conserved family of DNA methylases, transferring a methyl group onto the fifth carbon of a cytosine residue. The mammalian DNMT family includes three major members that have functional methylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3b0ad57e39385122e9939f46a76b505
https://doi.org/10.1016/j.jgg.2020.04.006
https://doi.org/10.1016/j.jgg.2020.04.006