Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Lixiang, Zhai"'
Autor:
Xuanming Guo, Pallavi Asthana, Lixiang Zhai, Ka Wing Cheng, Susma Gurung, Jiangang Huang, Jiayan Wu, Yijing Zhang, Arun Kumar Mahato, Mart Saarma, Mart Ustav, Hiu Yee Kwan, Aiping Lyu, Kui Ming Chan, Pingyi Xu, Zhao-Xiang Bian, Hoi Leong Xavier Wong
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Obesity, a global health challenge, is a major risk factor for multiple life-threatening diseases, including diabetes, fatty liver, and cancer. There is an ongoing need to identify safe and tolerable therapeutics for obesity management. Here
Externí odkaz:
https://doaj.org/article/a29cc025e9664a529d8c924433238848
Autor:
Lixiang Zhai, Haitao Xiao, Chengyuan Lin, Hoi Leong Xavier Wong, Yan Y. Lam, Mengxue Gong, Guojun Wu, Ziwan Ning, Chunhua Huang, Yijing Zhang, Chao Yang, Jingyuan Luo, Lu Zhang, Ling Zhao, Chenhong Zhang, Johnson Yiu-Nam Lau, Aiping Lu, Lok-Ting Lau, Wei Jia, Liping Zhao, Zhao-Xiang Bian
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract The incidence of metabolic syndrome is significantly higher in patients with irritable bowel syndrome (IBS), but the mechanisms involved remain unclear. Gut microbiota is causatively linked with the development of both metabolic dysfunctions
Externí odkaz:
https://doaj.org/article/4761893c769046958a1acdec4f252085
Autor:
Liqing Du, Zhaozhou Zhang, Lixiang Zhai, Shujun Xu, Wei Yang, Chunhua Huang, Chengyuan Lin, Linda L. D. Zhong, Zhaoxiang Bian, Ling Zhao
Publikováno v:
Chinese Medicine, Vol 18, Iss 1, Pp 1-13 (2023)
Abstract Background Dysregulation of gut microbiota–host bile acid (BA) co-metabolism is a critical pathogenic factor of diarrhea-predominant irritable bowel syndrome (IBS-D). Traditional Chinese Medicine (TCM), instructed by pattern differentiatio
Externí odkaz:
https://doaj.org/article/4b1ca2bb4e23405c9544ae96691b027d
Autor:
Xuanming Guo, Pallavi Asthana, Susma Gurung, Shuo Zhang, Sheung Kin Ken Wong, Samane Fallah, Chi Fung Willis Chow, Sijia Che, Lixiang Zhai, Zening Wang, Xin Ge, Zhixin Jiang, Jiayan Wu, Yijing Zhang, Xiaoyu Wu, Keyang Xu, Cheng Yuan Lin, Hiu Yee Kwan, Aiping Lyu, Zhongjun Zhou, Zhao-Xiang Bian, Hoi Leong Xavier Wong
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Insulin sensitivity declines with age via unclear mechanisms. Here, the authors show that the activity of membrane type 1 matrix metalloproteinase (MT1-MMP) is increased with ageing, leading to cleavage of the insulin receptor, and show that metaboli
Externí odkaz:
https://doaj.org/article/32333283ecad4975964575d74c627b97
Autor:
Lijuan Yu, Chunhua Huang, Wei Yang, Zhenxing Ren, Lifeng Li, Huiyuan Cheng, Chengyuan Lin, Lixiang Zhai, Ziwan Ning, Hoileong Xavier Wong, Quanbin Han, Wei Jia, Zhaoxiang Bian, Ling Zhao
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Cinnamon protects against irritable bowel syndrome with diarrhea (IBS-D) in humans, but its efficacy and underlying mechanism of action remain poorly understood. Maternally separated (MS) IBS-D rat model and 2,4,6-trinitrobenzene sulfonic acid (TNBS)
Externí odkaz:
https://doaj.org/article/ed890778d91b4eb0bbb7662d2d658e4c
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 141, Iss , Pp 111931- (2021)
Inflammatory bowel disease (IBD) is a chronic inflammatory intestinal disorder that is difficult to cure and characterized by periods of relapse. To face the challenges of limited treatment strategies and drawbacks of conventional medications, develo
Externí odkaz:
https://doaj.org/article/3837d7a70889445687454b46ef424cc5
Autor:
Lixiang Zhai, Tao Huang, Hai-tao Xiao, Pei-gen Wu, Cheng-yuan Lin, Zi-wan Ning, Ling Zhao, Hiu Yee Anna Kwan, Xian-jing Hu, Hoi Leong Xavier Wong, Xian-qian Li, Zhao-xiang Bian
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Ulcerative colitis (UC) causes chronic inflammation and damage to the colonic mucosal layer. Recent studies have reported significant changes in phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) in UC patients and oral administration of PC h
Externí odkaz:
https://doaj.org/article/b04323def6da43f595ef27aa3d1bba7e
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 12846 (2021)
Type 2 diabetes (T2D) is a worldwide prevalent metabolic disorder defined by high blood glucose levels due to insulin resistance (IR) and impaired insulin secretion. Understanding the mechanism of insulin action is of great importance to the continui
Externí odkaz:
https://doaj.org/article/ad4b5c19120441fab9c55d4810d076b8
Autor:
Jianzhong Xu, Xinghua Zhang, Wenhui Zhao, Lixiang Zhai, Miao Zhao, Jinsen Shi, Junying Sun, Yanmei Liu, Conghui Xie, Yulong Tan, Kemei Li, Xinlei Ge, Qi Zhang, Shichang Kang
Publikováno v:
Earth System Science Data Discussions; 12/14/2023, p1-45, 45p
Autor:
Peigen Wu, Churui Chang, Guanglin Zhu, Lixiang Zhai, Xu Zhang, Qiuchan Huan, Zhengxian Gao, Huan Deng, Yue Liang, Haitao Xiao
Publikováno v:
Drug Design, Development and Therapy.
Peigen Wu,1â 3 Churui Chang,3 Guanglin Zhu,4 Lixiang Zhai,5 Xu Zhang,3 Qiuchan Huan,1,3 Zhengxian Gao,1,3 Huan Deng,2 Yue Liang,1 Haitao Xiao2,3 1Department of Pharmacy, Peking University Shenzhen Hospital, Shenzhen, Peopleâs Republic of Ch