Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Lixia Ding"'
Autor:
Han Wang, Huiying Sun, Bilin Liang, Fang Zhang, Fan Yang, Bowen Cui, Lixia Ding, Xiang Wang, Ronghua Wang, Jiaoyang Cai, Yanjing Tang, Jianan Rao, Wenting Hu, Shuang Zhao, Wenyan Wu, Xiaoxiao Chen, Kefei Wu, Junchen Lai, Yangyang Xie, Benshang Li, Jingyan Tang, Shuhong Shen, Yu Liu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract For around half of the pediatric B-lineage acute lymphoblastic leukemia (B-ALL) patients, the molecular mechanism of relapse remains unclear. To fill this gap in knowledge, here we characterize the chromatin accessibility landscape in pediat
Externí odkaz:
https://doaj.org/article/fe96c0b766af471fa983e4b57c10585c
Autor:
Wenjie Li, Lixia Ding, Wenhua Shi, Xinyu Wan, Xiaomin Yang, Jing Yang, Tianyi Wang, Lili Song, Xiang Wang, Yani Ma, Chengjuan Luo, Jingyan Tang, Longjun Gu, Jing Chen, Jun Lu, Yanjing Tang, Benshang Li
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-11 (2023)
Abstract Background CD19-targeted chimeric antigen receptor T-cell (CAR-T) therapy has shown remarkable efficacy in treating relapsed or refractory pediatric B-lineage acute lymphoblastic leukemia (B-ALL). However, poor results are obtained when the
Externí odkaz:
https://doaj.org/article/3191a08fad53487682a65726b00278f6
Autor:
Lili Song, Peifeng Li, Huiying Sun, Lixia Ding, Jing Wang, Benshang Li, Bin-Bing S. Zhou, Haizhong Feng, Yanxin Li
Publikováno v:
Blood Science, Vol 5, Iss 1, Pp 39-50 (2023)
Tumor relapse is the major cause of treatment failure in childhood acute lymphoblastic leukemia (ALL), yet the underlying mechanisms are still elusive. Here, we demonstrate that phosphoribosyl pyrophosphate synthetase 2 (PRPS2) mutations drive ALL re
Externí odkaz:
https://doaj.org/article/98b98f79a4104f64b0f67302fa87b235
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 9, Iss 11, Pp n/a-n/a (2021)
Abstract Background Osteopetrosis is characterized by increased bone density and bone marrow cavity stenosis due to a decrease in the number of osteoclasts or the dysfunction of their differentiation and absorption properties usually caused by bialle
Externí odkaz:
https://doaj.org/article/b081c2e76e334c6e83a804ab1ec8098b
Autor:
Yang Li, Ting Li, Yuejia Tang, Zhiyan Zhan, Lixia Ding, Lili Song, Tingting Yu, Yi Yang, Jing Ma, Yingwen Zhang, Ying Zhou, Song Gu, Min Xu, Yijin Gao, Yanxin Li
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234262 (2020)
p53 is one of the most extensively studied proteins in cancer research. Mutations in p53 generally abolish normal p53 function, and some mutants can gain new oncogenic functions. However, the mechanisms underlying p53 mutation-driven cancer remains t
Externí odkaz:
https://doaj.org/article/79d6e69f485441d298956d2af327a7cf
Autor:
Tianyi Wang, Yanjing Tang, Jiaoyang Cai, Xinyu Wan, Shaoyan Hu, Xiaoxi Lu, Zhiwei Xie, Xiaohong Qiao, Hui Jiang, Jingbo Shao, Fan Yang, Hong Ren, Qing Cao, Juan Qian, Jian Zhang, Kang An, Jianmin Wang, Chengjuan Luo, Huanhuan Liang, Yan Miao, Yani Ma, Xiang Wang, Lixia Ding, Lili Song, Hailong He, Wenhua Shi, Peifang Xiao, Xiaomin Yang, Jing Yang, Wenjie Li, Yiping Zhu, Ningling Wang, Longjun Gu, Qimin Chen, Jingyan Tang, Jun J. Yang, Cheng Cheng, Wing Leung, Jing Chen, Jun Lu, Benshang Li, Ching-Hon Pui
Publikováno v:
Journal of Clinical Oncology. 41:1670-1683
PURPOSE We determined the safety and efficacy of coadministration of CD19- and CD22-chimeric antigen receptor (CAR) T cells in patients with refractory disease or high-risk hematologic or isolated extramedullary relapse of B-acute lymphoblastic leuke
Publikováno v:
The Journal of Organic Chemistry. 87:15564-15570
Autor:
Lili Song, Peifeng Li, Huiying Sun, Lixia Ding, Jing Wang, Benshang Li, Bin-Bing S. Zhou, Haizhong Feng, Yanxin Li
Publikováno v:
Blood Science. 5:39-50
Outcomes of Anti-CD19 CAR-T Treatment of Pediatric B-ALL with Bone Marrow and Extramedullary Relapse
Autor:
Xiang Wang, Yani Ma, Yanjing Tang, Lixia Ding, Jingyan Tang, Yan Miao, Xinyu Wan, Long-Jun Gu, Xiaomin Yang, Tianyi Wang, Fan Yang, Chengjuan Luo, Jun Lu, Lili Song, Benshang Li, Jing Chen
Publikováno v:
Cancer Research and Treatment. 54:917-925
Purpose Anti-CD19 chimeric antigen receptor T-cell immunotherapy (19CAR-T) has achieved impressive clinical results in adult and pediatric relapsed/refractory (r/r) B-lineage acute lymphoblastic leukemia (B-ALL). However, the application and effect o
Publikováno v:
Organic Chemistry Frontiers. 9:5637-5642
Lewis acid-promoted cyclizations of o-alkyloxyphenyl-substituted ynamides for the construction of medicinally relevant 2-amidobenzofurans are described. A series of 3-acyl or 3-unsubstituted 2-amidobenzofurans could be effectively constructed.