Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Livnat Jerby"'
Autor:
Avinash Das Sahu, Joo S Lee, Zhiyong Wang, Gao Zhang, Ramiro Iglesias‐Bartolome, Tian Tian, Zhi Wei, Benchun Miao, Nishanth Ulhas Nair, Olga Ponomarova, Adam A Friedman, Arnaud Amzallag, Tabea Moll, Gyulnara Kasumova, Patricia Greninger, Regina K Egan, Leah J Damon, Dennie T Frederick, Livnat Jerby‐Arnon, Allon Wagner, Kuoyuan Cheng, Seung Gu Park, Welles Robinson, Kevin Gardner, Genevieve Boland, Sridhar Hannenhalli, Meenhard Herlyn, Cyril Benes, Keith Flaherty, Ji Luo, J Silvio Gutkind, Eytan Ruppin
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 3, Pp 1-21 (2019)
Abstract Most patients with advanced cancer eventually acquire resistance to targeted therapies, spurring extensive efforts to identify molecular events mediating therapy resistance. Many of these events involve synthetic rescue (SR) interactions, wh
Externí odkaz:
https://doaj.org/article/3e0d9e37ccd24f31aaa5e8abf6557875
Autor:
Amy Li, Rebecca H. Herbst, David Canner, Jason M. Schenkel, Olivia C. Smith, Jonathan Y. Kim, Michelle Hillman, Arjun Bhutkar, Michael S. Cuoco, C. Garrett Rappazzo, Patricia Rogers, Celeste Dang, Livnat Jerby-Arnon, Orit Rozenblatt-Rosen, Le Cong, Michael Birnbaum, Aviv Regev, Tyler Jacks
Publikováno v:
Cell Reports, Vol 29, Iss 10, Pp 2998-3008.e8 (2019)
Summary: Regulatory T cells (Tregs) can impair anti-tumor immune responses and are associated with poor prognosis in multiple cancer types. Tregs in human tumors span diverse transcriptional states distinct from those of peripheral Tregs, but their c
Externí odkaz:
https://doaj.org/article/23e127cdd30c49738de5fb370ca4ae6d
Autor:
Joo Sang Lee, Avinash Das, Livnat Jerby-Arnon, Rand Arafeh, Noam Auslander, Matthew Davidson, Lynn McGarry, Daniel James, Arnaud Amzallag, Seung Gu Park, Kuoyuan Cheng, Welles Robinson, Dikla Atias, Chani Stossel, Ella Buzhor, Gidi Stein, Joshua J. Waterfall, Paul S. Meltzer, Talia Golan, Sridhar Hannenhalli, Eyal Gottlieb, Cyril H. Benes, Yardena Samuels, Emma Shanks, Eytan Ruppin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Synthetic lethality (SL) offers a new precision oncology approach, which is based on targeting cancer-specific vulnerabilities across the whole genome, going beyond cancer drivers. The authors develop an approach termed ISLE to identify clinically re
Externí odkaz:
https://doaj.org/article/3a4240165a2541088f4b9ac5ea8738dc
Autor:
Tuulia Hyötyläinen, Livnat Jerby, Elina M. Petäjä, Ismo Mattila, Sirkku Jäntti, Petri Auvinen, Amalia Gastaldelli, Hannele Yki-Järvinen, Eytan Ruppin, Matej Orešič
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Non-alcoholic fatty liver disease (NAFLD) is a risk factor for other types of liver diseases. Here, the authors integrate transcriptomic and metabolomic data from patients with NAFLD with a genome-scale metabolic model to paint a comprehensive pictur
Externí odkaz:
https://doaj.org/article/6e1fc59352494a63bee5cc567082d455
Publikováno v:
Molecular Systems Biology, Vol 7, Iss 1, Pp 1-10 (2011)
Abstract The interest in studying metabolic alterations in cancer and their potential role as novel targets for therapy has been rejuvenated in recent years. Here, we report the development of the first genome‐scale network model of cancer metaboli
Externí odkaz:
https://doaj.org/article/5e9af3564a7f41759c7488cebe4244d0
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp 1-9 (2010)
Abstract The computational study of human metabolism has been advanced with the advent of the first generic (non‐tissue specific) stoichiometric model of human metabolism. In this study, we present a new algorithm for rapid reconstruction of tissue
Externí odkaz:
https://doaj.org/article/2323e851a6f04615ac64bffc50aeaba5
Autor:
Tamar Geiger, Eytan Ruppin, Neta Erez, Livnat Jerby-Arnon, Michael Selitrennik, Lir Beck, Michal Harel, Tamar Shami, Joo Sang Lee, Georgina D. Barnabas
Supplementary Figure S2. Cell proliferation and glycolytic activity upon transient IDH2 overexpression A-B - Quantification of the integrated density of cellROX staining in control and IDH2-overexpressing cells (A) and in the control and IDH2 knockou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e614cea98e2d091e46bf06bf7751f2c2
https://doi.org/10.1158/0008-5472.22426005.v1
https://doi.org/10.1158/0008-5472.22426005.v1
Autor:
Tamar Geiger, Eytan Ruppin, Neta Erez, Livnat Jerby-Arnon, Michael Selitrennik, Lir Beck, Michal Harel, Tamar Shami, Joo Sang Lee, Georgina D. Barnabas
Supplementary Table S3: Eigenprotein modules and the metabolic pathway enrichments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3052a7943f54fdc88e0272f7b9e5b371
https://doi.org/10.1158/0008-5472.22425975
https://doi.org/10.1158/0008-5472.22425975
Autor:
Tamar Geiger, Eytan Ruppin, Neta Erez, Livnat Jerby-Arnon, Michael Selitrennik, Lir Beck, Michal Harel, Tamar Shami, Joo Sang Lee, Georgina D. Barnabas
Cancer-specific metabolic phenotypes and their vulnerabilities represent a viable area of cancer research. In this study, we explored the association of breast cancer subtypes with different metabolic phenotypes and identified isocitrate dehydrogenas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3b537d670ff5abd8b28e02506301ef
https://doi.org/10.1158/0008-5472.c.6512196
https://doi.org/10.1158/0008-5472.c.6512196
Autor:
Eytan Ruppin, Tamar Geiger, Matej Oresic, Mika Hilvo, Gideon Y. Stein, Carsten Denkert, Lior Wolf, Livnat Jerby
PDF file, 40K, Intracellular ROS levels are reduced in metastatic BC cells. The distribution of superoxide levels in metastatic (blue) and non-metastatic (red) cell-lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c983787bf2faee511485192910e2a779
https://doi.org/10.1158/0008-5472.22395282.v1
https://doi.org/10.1158/0008-5472.22395282.v1