Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Liviu Movileanu"'
Autor:
Mohammad Ahmad, Jeung-Hoi Ha, Lauren A. Mayse, Maria F. Presti, Aaron J. Wolfe, Kelsey J. Moody, Stewart N. Loh, Liviu Movileanu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Sensitive and accurate approaches for protein detection have many potential applications. Here the authors show how engineered protein nanopore sensors, consisting of a monobody fused to a single-polypeptide nanopore, can be used for highly specific
Externí odkaz:
https://doaj.org/article/1f2b1191daee43b2bc50ec7144ff89b9
Autor:
Lauren Ashley Mayse, Ali Imran, Motahareh Ghahari Larimi, Michael S. Cosgrove, Aaron James Wolfe, Liviu Movileanu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Nanopores are powerful tools for sampling protein-peptide interactions. Here, the authors convert a protein-based nanopore into a sensitive biosensor to characterize the complex binding of WDR5 protein to a 14-residue ligand.
Externí odkaz:
https://doaj.org/article/8fe65ee04c5640f0a0452231f33d85e8
Autor:
Lauren A. Mayse, Liviu Movileanu
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12095 (2023)
β barrels are ubiquitous proteins in the outer membranes of mitochondria, chloroplasts, and Gram-negative bacteria. These transmembrane proteins (TMPs) execute a wide variety of tasks. For example, they can serve as transporters, receptors, membrane
Externí odkaz:
https://doaj.org/article/5a3977b15dcb404ab5d2abcc8c46cc9b
Autor:
Elif Eren, Jagamya Vijayaraghavan, Jiaming Liu, Belete R Cheneke, Debra S Touw, Bryan W Lepore, Mridhu Indic, Liviu Movileanu, Bert van den Berg
Publikováno v:
PLoS Biology, Vol 10, Iss 1, p e1001242 (2012)
Many Gram-negative bacteria, including human pathogens such as Pseudomonas aeruginosa, do not have large-channel porins. This results in an outer membrane (OM) that is highly impermeable to small polar molecules, making the bacteria intrinsically res
Externí odkaz:
https://doaj.org/article/0c3fb50559e149ae8828fa5d4989b8de
Autor:
Ali Imran, Brandon S. Moyer, Dan Kalina, Thomas M. Duncan, Kelsey J. Moody, Aaron J. Wolfe, Michael S. Cosgrove, Liviu Movileanu
Publikováno v:
ACS Chemical Biology. 17:1586-1597
Progress in tumor sequencing and cancer databases has created an enormous amount of information that scientists struggle to sift through. While several research groups have created computational methods to analyze these databases, much work still rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e4e0f0423c72cdb91734461556eeb8
https://doi.org/10.1021/acschembio.2c00273
https://doi.org/10.1021/acschembio.2c00273
Autor:
Ali Imran, Brandon S. Moyer, Aaron J. Wolfe, Michael S. Cosgrove, Dmitrii E. Makarov, Liviu Movileanu
Publikováno v:
The Journal of Physical Chemistry Letters. 13:4021-4028
Surface-tethered ligand-receptor complexes are key components in biological signaling and adhesion. They also find increasing utility in single-molecule assays and biotechnological applications. Here, we study the real-time binding kinetics between v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13606c05edadb5bf23e890b8374984db
https://doi.org/10.1021/acs.jpclett.2c00621
https://doi.org/10.1021/acs.jpclett.2c00621
Protein detection and biomarker profiling have implications in basic research and molecular diagnostics. Substantial progress has been made in protein analytics using nanopores and the resistive-pulse technique. Yet, a long-standing challenge is impl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422f7f24d4c464c49ee1713c0f7635ec
Autor:
Mohammad Ahmad, Jeung-Hoi Ha, Lauren A. Mayse, Maria F. Presti, Aaron J. Wolfe, Kelsey J. Moody, Stewart N. Loh, Liviu Movileanu
Protein detection and biomarker profiling have wide-ranging implications in many areas of basic research and molecular diagnostics. Substantial progress has been made in protein analytics using nanopores and the resistive-pulse technique. Yet, a long
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceff005eb143445fccd2e931d4fdc428
https://doi.org/10.1101/2022.10.12.511930
https://doi.org/10.1101/2022.10.12.511930
Autor:
Mohammad Ahmad, Liviu Movileanu
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1865:184173
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0177a6404e5508e729100935365327b
https://doi.org/10.1016/j.bbamem.2023.184173
https://doi.org/10.1016/j.bbamem.2023.184173
Publikováno v:
Langmuir. 36:15247-15257
Previous studies of transmembrane protein channels have employed noise analysis to examine their statistical current fluctuations. In general, these explorations determined a substrate-induced amplification in the Gaussian white noise of these system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0b9dbf35b06ffcbaf5200738931f706
https://doi.org/10.1021/acs.langmuir.0c02498
https://doi.org/10.1021/acs.langmuir.0c02498