Global circRNA expression changes predate clinical and histological improvements of psoriasis patients upon secukinumab treatment.

Autor: Sabine Seeler, Liviu-Ionut Moldovan, Trine Bertelsen, Henrik Hager, Lars Iversen, Claus Johansen, Jørgen Kjems, Lasse Sommer Kristensen

Publikováno v: PLoS ONE, Vol 17, Iss 9, p e0275219 (2022)

Psoriasis is a common chronic inflammatory skin disease accompanied by heterogenous clinical and histological features, including a characteristic keratinocyte hyperproliferation and dermal immunogenic profile. In addition, psoriasis is associated wi

Externí odkaz: https://doaj.org/article/8509030fd17848ec958f7cae86d00585

The HSP90 inhibitor RGRN‐305 exhibits strong immunomodulatory effects in human keratinocytes

Autor: Gautam S. Ghatnekar, Liviu Ionut Moldovan, Rikke S Hansen, Anne Bregnhøj, Christina L. Grek, Claus Johansen, Lars Iversen, Katrine K H Thuesen, Lasse Sommer Kristensen

Publikováno v: Hansen, R S, Thuesen, K K, Bregnhøj, A, Moldovan, L I, Kristensen, L S, Grek, C L, Ghatnekar, G S, Iversen, L & Johansen, C 2021, ' The HSP90 inhibitor RGRN-305 exhibits strong immunomodulatory effects in human keratinocytes ', Experimental Dermatology, vol. 30, no. 6, pp. 773-781 . https://doi.org/10.1111/exd.14302

Keratinocytes are the key cellular target for IL-17A-mediated effects in psoriasis and HSP90 is important for IL-17A-mediated signalling. RGRN-305 is a novel HSP90 inhibitor reported to reduce psoriatic phenotypes in preclinical animal models. The ai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b241235324b480ecc2d1377251fda6c2
https://doi.org/10.1111/exd.14302

Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans

Autor: Søren R. Paludan, Alon Schneider Hait, Sathya Darmalinggam, Mette Christiansen, Simon Muller Larsen, Jørgen Kjems, Darshana D. Kadekar, Kristina Eriksson, Serge Mostowy, Liviu Ionut Moldovan, Nanna-Sophie Brinck Andersen, Vanessa Sancho-Shimizu, Trine H. Mogensen, Lasse Sommer Kristensen, Isobel Parkes, David Olagnier, Marie Helleberg, Demi van der Horst, Michelle M. Thomsen, Mette Ratzer Freytag, Kristian Alsbjerg Skipper, Stine H. Rahbek, Jacob Giehm Mikkelsen, Christian Brandt, Chiranjeevi Bodda, Fanghui Ren

Publikováno v: Hait, A S, Olagnier, D, Sancho-Shimizu, V, Skipper, K A, Helleberg, M, Larsen, S M, Bodda, C, Moldovan, L I, Ren, F, Brinck Andersen, N-S, Thomsen, M M, Freytag, M R, Darmalinggam, S, Parkes, I, Kadekar, D D, Rahbek, S H, van der Horst, D, Kristensen, L S, Eriksson, K, Kjems, J, Mostowy, S, Christiansen, M, Mikkelsen, J G, Brandt, C T, Paludan, S R & Mogensen, T H 2020, ' Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans ', Science Immunology, vol. 5, no. 54, eabc2691 . https://doi.org/10.1126/sciimmunol.abc2691
Hait, A S, Olagnier, D, Sancho-Shimizu, V, Skipper, K A, Helleberg, M, Larsen, S M, Bodda, C, Moldovan, L I, Ren, F, Andersen, N S B, Thomsen, M M, Freytag, M R, Darmalinggam, S, Parkes, I, Kadekar, D D, Rahbek, S H, van der Horst, D, Kristensen, L S, Eriksson, K, Kjems, J, Mostowy, S, Christiansen, M, Mikkelsen, J G, Brandt, C T, Paludan, S R & Mogensen, T H 2021, ' Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans ', Science immunology, vol. 5, no. 54, eabc2691 . https://doi.org/10.1126/SCIIMMUNOL.ABC2691
Science Immunology

Recurrent herpesvirus infections can manifest in different forms of disease, including cold sores, genital herpes, and encephalitis. There is an incomplete understanding of the genetic and immunological factors conferring susceptibility to recurrent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e2d27ad827935f3a3c72318f2fa311
https://pure.au.dk/portal/da/publications/defects-in-lc3b2-and-atg4a-underlie-hsv2-meningitis-and-reveal-a-critical-role-for-autophagy-in-antiviral-defense-in-humans(660e28c6-e88f-4155-8813-69748e66d63d).html

High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome

Autor: Thomas B. Hansen, Morten T. Venø, Thomas Levin Andersen, Trine Line Hauge Okholm, Claus Johansen, Lars Iversen, Lasse Sommer Kristensen, Liviu Ionut Moldovan, Jørgen Kjems, Henrik Hager

Publikováno v: BMC Medical Genomics
Moldovan, L-I, Hansen, T B, Venø, M T, Okholm, T L H, Andersen, T L, Hager, H, Iversen, L, Kjems, J, Johansen, C & Kristensen, L S 2019, ' High-throughput RNA sequencing from paired lesional-and non-lesional skin reveals major alterations in the psoriasis circRNAome ', BMC Medical Genomics, vol. 12, no. 1, 174 . https://doi.org/10.1186/s12920-019-0616-2
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-17 (2019)
Moldovan, L I, Hansen, T B, Venø, M T, Okholm, T L H, Andersen, T L, Hager, H, Iversen, L, Kjems, J, Johansen, C & Kristensen, L S 2019, ' High-throughput RNA sequencing from paired lesional-and non-lesional skin reveals major alterations in the psoriasis circRNAome ', BMC Medical Genomics, vol. 12, 174 . https://doi.org/10.1186/s12920-019-0616-2

Background Psoriasis is a chronic inflammatory skin disease characterized by hyperproliferation and abnormal differentiation of keratinocytes. It is one of the most prevalent chronic inflammatory skin conditions in adults worldwide, with a considerab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0c5a213fae2d65ab7176059f3d0f92
https://doi.org/10.1101/581066

448 A comprehensive analysis of coding and non coding transcriptomic changes in cutaneous squamous cell carcinoma

Autor: Lajos Kemény, Lasse Sommer Kristensen, Jan Lapins, Andor Pivarcsi, Lorenzo Pasquali, K. Das Mahapatra, E. Sonkoly, Eszter Baltás, István Németh, Claudia Kutter, Liviu Ionut Moldovan, Jonas Nørskov Søndergaard, Jørgen Kjems

Publikováno v: Journal of Investigative Dermatology. 139:S292

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50b1ac2ca45a505063da167975219292
https://doi.org/10.1016/j.jid.2019.07.498