Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Liviu Aron"'
Autor:
Liviu Aron, Chenxi Qiu, Zhen Kai Ngian, Marianna Liang, Derek Drake, Jaejoon Choi, Marty A. Fernandez, Perle Roche, Emma L. Bunting, Ella K. Lacey, Sara E. Hamplova, Monlan Yuan, Michael S. Wolfe, David A. Bennett, Eunjung A. Lee, Bruce A. Yankner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Many aging individuals accumulate the pathology of Alzheimer’s disease (AD) without evidence of cognitive decline. Here we describe an integrated neurodegeneration checkpoint response to early pathological changes that restricts further di
Externí odkaz:
https://doaj.org/article/e84a41f3caaa44a194226f2627e04640
Publikováno v:
PLoS Genetics, Vol 6, Iss 8 (2010)
The most common Rhodopsin (Rh) mutation associated with autosomal dominant retinitis pigmentosa (ADRP) in North America is the substitution of proline 23 by histidine (Rh(P23H)). Unlike the wild-type Rh, mutant Rh(P23H) exhibits folding defects and f
Externí odkaz:
https://doaj.org/article/f037d599a2b847168b68427afd4d14cb
Publikováno v:
PLoS Biology, Vol 8, Iss 4, p e1000349 (2010)
The mechanisms underlying the selective death of substantia nigra (SN) neurons in Parkinson disease (PD) remain elusive. While inactivation of DJ-1, an oxidative stress suppressor, causes PD, animal models lacking DJ-1 show no overt dopaminergic (DA)
Externí odkaz:
https://doaj.org/article/78f01b662edc40ecad99f2127499e886
Autor:
Edgar R Kramer, Liviu Aron, Geert M J Ramakers, Sabine Seitz, Xiaoxi Zhuang, Klaus Beyer, Marten P Smidt, Rüdiger Klein
Publikováno v:
PLoS Biology, Vol 5, Iss 3, p e39 (2007)
Support of ageing neurons by endogenous neurotrophic factors such as glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) may determine whether the neurons resist or succumb to neurodegeneration. GDNF has be
Externí odkaz:
https://doaj.org/article/f3771b46fd244cb5931d30cdd331f811
Publikováno v:
Curr Opin Neurobiol
The aging brain is shaped by many structural and functional alterations. Recent cross-disciplinary efforts have uncovered powerful and integrated adaptive mechanisms that promote brain health and prevent functional decline during aging. Here, we revi
Autor:
Bruce A. Yankner, Liviu Aron, Christophe Legendre, Fabiola Terzi, Guillaume Canaud, Clément Hoguin, Pierre Isnard, Sato Magassa
Publikováno v:
J Am Soc Nephrol
Background Chronic kidney disease is associated with the loss of functional nephrons, leading to increased mechanical and metabolic stress in the remaining cells, particularly for cells constituting the filtration barrier, such as podocytes. The fail
Autor:
Monica P. Colaiácovo, Bruce A. Yankner, Joseph M. Zullo, David A. Bennett, William H. Klein, Derek Drake, Patrick O’Hern, Noah Davidsohn, Sameer C. Dhamne, Liviu Aron, Chai An Mao, George M. Church, Alexander Rotenberg
Publikováno v:
Nature
The mechanisms that extend lifespan in humans are poorly understood. Here we show that extended longevity in humans is associated with a distinct transcriptome signature in the cerebral cortex that is characterized by downregulation of genes related
Autor:
Liviu Aron, Bruce A. Yankner
Publikováno v:
Nature Digest. 14:27-29
Autor:
Richie E. Kohman, Edward S. Boyden, Songlei Liu, Daniel Goodwin, Thomas C. Ferrante, Conor K. Camplisson, George M. Church, Sukanya Punthambaker, Asmamaw T Wassie, Anubhav Sinha, Alex Skrynnyk, Kunal Jindal, Michael Farrell, Nicholas Conway, Fei Chen, Denitsa Milanova, Eswar Prasad Ramachandran Iyer, Bruce A. Yankner, Stewart Rudnicki, Paul Reginato, Shahar Alon, John Aach, Liviu Aron, Jernej Murn
We present Barcoded Oligonucleotides Ligated On RNA Amplified for Multiplexed and parallel In-Situ analysis (BOLORAMIS), a reverse-transcription (RT)-free method for spatially-resolved, targeted, in-situ RNA identification of single or multiple targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1641ca214322f7d235a7bde9dfa974f
https://doi.org/10.1101/281121
https://doi.org/10.1101/281121
Autor:
Haeyoung Kim, Ying Pan, Tun Hsiang Yang, Hyun-Min Kim, Tao Lu, Liviu Aron, Monica P. Colaiácovo, Yiwen Chen, David A. Bennett, Joseph M. Zullo, Derek Drake, Bruce A. Yankner, X. Shirley Liu
Publikováno v:
Nature
Human neurons are functional over an entire lifetime, yet the mechanisms that preserve function and protect against neurodegeneration during ageing are unknown. Here we show that induction of the repressor element 1-silencing transcription factor (RE