Contribution of local regeneration of glucocorticoids to tissue steroid pools

Autor: Khan, Shazia, Livingstone, Dawn E. W, Zielinska, Agnieszka, Doig, Craig L, Cobice, Diego F, Esteves, Cristina L, Man, Janet Tak Yun, Homer, Natalie Z.M., Seckl, Jonathan R, Mackay, C.Logan, Webster, Scott P, Lavery, Gareth G, Chapman, Karen E, Walker, Brian R, Andrew, Ruth

Publikováno v: Khan, S, Livingstone, D E W, Zielinska, A, Doig, C L, Cobice, D F, Esteves, C L, Man, J T Y, Homer, N Z M, Seckl, J R, Mackay, C L, Webster, S P, Lavery, G G, Chapman, K E, Walker, B R & Andrew, R 2023, ' Contribution of local regeneration of glucocorticoids to tissue steroid pools ', Journal of Endocrinology . https://doi.org/10.1530/JOE-23-0034

11β-Hydroxysteroid dehydrogenase 1 (11βHSD1) is a drug target to attenuate adverse effects of chronic glucocorticoid excess. It catalyses intracellular regeneration of active glucocorticoids in tissues including brain, liver and adipose tissue (cou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::4b54a9913dae93121ea0c40b6dbf4c35
https://www.pure.ed.ac.uk/ws/files/361561412/Khan_et_al_merged.pdf

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Metabolic dysfunction in female mice with disruption of 5α-reductase 1

Autor: Livingstone, Dawn E W, Di Rollo, Emma M, Mak, Tracy C-S, Sooy, Karen, Walker, Brian R, Andrew, Ruth

Publikováno v: Livingstone, D E W, Di Rollo, E M, Mak, T C-S, Sooy, K, Walker, B R & Andrew, R 2017, ' Metabolic dysfunction in female mice with disruption of 5α-reductase 1 ', Journal of Endocrinology, vol. 232, no. 1, pp. 29-36 . https://doi.org/10.1530/JOE-16-0125
The Journal of Endocrinology

5-Reductases irreversibly catalyse A-ring reduction of pregnene steroids, including glucocorticoids and androgens. Genetic disruption of 5-reductase 1 in male mice impairs glucocorticoid clearance and predisposes to glucose intolerance and hepa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c2d6cfda69fff1f290c53e4338199717
https://www.pure.ed.ac.uk/ws/files/29499804/29.full.pdf

Role of Hepatic Glucocorticoid Receptor in Metabolism in Models of 5αR1 Deficiency in Male Mice.

Autor: Mak, Tracy C S, Livingstone, Dawn E W, Nixon, Mark, Walker, Brian R, Andrew, Ruth

Publikováno v: Endocrinology; Sep2019, Vol. 160 Issue 9, p2061-2073, 13p