Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Livia Pica-Mattoccia"'
Autor:
Alexander B Taylor, Livia Pica-Mattoccia, Chiara M Polcaro, Enrica Donati, Xiaohang Cao, Annalisa Basso, Alessandra Guidi, Anastasia R Rugel, Stephen P Holloway, Timothy J C Anderson, P John Hart, Donato Cioli, Philip T LoVerde
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 10, p e0004132 (2015)
For over two decades, a racemic mixture of oxamniquine (OXA) was administered to patients infected by Schistosoma mansoni, but whether one or both enantiomers exert antischistosomal activity was unknown. Recently, a ~30 kDa S. mansoni sulfotransferas
Externí odkaz:
https://doaj.org/article/3b7c1e7a5a064fd091f62e935ccc0828
Autor:
Livia Pica-Mattoccia, Daniele Carlini, Alessandra Guidi, Velasco Cimica, Fabio Vigorosi, Donato Cioli
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 101, Pp 307-312 (2006)
Available evidence suggests that the antischistosomal drug oxamniquine is converted to a reactive ester by a schistosome enzyme that is missing in drug-resistant parasites. This study presents data supporting the idea that the active ester is a sulfa
Externí odkaz:
https://doaj.org/article/895a872e6cc045f8b21c1fa661c3e437
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 87, Pp 211-214 (1992)
The objective of this study is to determine whether various hycanthone resistant strains of schistosomes which have been independently isolated are all affected in the same gene. A strain obtained from a Brazilian patient was compared with a strain o
Externí odkaz:
https://doaj.org/article/14d253f49c5747c39787cacca79e24de
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 84, Pp 38-45 (1989)
Genetic crosses between phenotypically resistant and sensitive schistosomes demonstrated that resistance to hycanthone and oxamniquine behaves like a recessive trait, thus suggesting that resistance is due to the lack of some factor. We hypothesized
Externí odkaz:
https://doaj.org/article/8d419e6eb44144888d2123e7877a0d26
Autor:
Reid S. Tarpley, Chiara M. Polcaro, Stephen P. Holloway, Nathaniel E. Clark, P. John Hart, Alexander B. Taylor, Stanton F. McHardy, Donato Cioli, Enrica Donati, Philip T. LoVerde, Kenneth M. Roberts, Livia Pica-Mattoccia, Paul F. Fitzpatrick, Xiaohang Cao
Publikováno v:
The Journal of biological chemistry
292 (2017): 11154–11164. doi:10.1074/jbc.M116.766527
info:cnr-pdr/source/autori:Taylor A.B. (a,c); Roberts K.M. (d); Cao X. (a); Clark N.E. (a); Holloway S.P. (a); Donati E. (e); Polcaro C.M. (e); Pica-Mattoccia L. (f); Tarpley R.S. (g); McHardy S.F. (g); Cioli D. (e); LoVerde P.T. (a,b); Fitzpatrick P.F. (a); Hart P.J. (a,c,h)/titolo:Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy/doi:10.1074%2Fjbc.M116.766527/rivista:The Journal of biological chemistry (Print)/anno:2017/pagina_da:11154/pagina_a:11164/intervallo_pagine:11154–11164/volume:292
292 (2017): 11154–11164. doi:10.1074/jbc.M116.766527
info:cnr-pdr/source/autori:Taylor A.B. (a,c); Roberts K.M. (d); Cao X. (a); Clark N.E. (a); Holloway S.P. (a); Donati E. (e); Polcaro C.M. (e); Pica-Mattoccia L. (f); Tarpley R.S. (g); McHardy S.F. (g); Cioli D. (e); LoVerde P.T. (a,b); Fitzpatrick P.F. (a); Hart P.J. (a,c,h)/titolo:Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy/doi:10.1074%2Fjbc.M116.766527/rivista:The Journal of biological chemistry (Print)/anno:2017/pagina_da:11154/pagina_a:11164/intervallo_pagine:11154–11164/volume:292
The antischistosomal prodrug oxamniquine is activated by a sulfotransferase (SULT) in the parasitic flatworm Schistosoma mansoni. Of the three main human schistosome species, only S. mansoni is sensitive to oxamniquine therapy despite the presence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca6f5cfc7a36fdcd4465f7051c1803c
https://doi.org/10.1074/jbc.m116.766527
https://doi.org/10.1074/jbc.m116.766527
Autor:
Singam Naveen Kumar, Malapaka Chandrasekharam, Vaidya Jayathirtha Rao, Partha Sarathi Sadhu, Donato Cioli, Livia Pica-Mattoccia
Publikováno v:
Bioorganic & medicinal chemistry letters
22 (2012): 1103–1106. doi:10.1016/j.bmcl.2011.11.108
info:cnr-pdr/source/autori:Partha Sarathi Sadhu a; Singam Naveen Kumar a; Malapaka Chandrasekharam b; Livia Pica-Mattoccia c; Donato Cioli c; Vaidya Jayathirtha Rao a/titolo:Synthesis of new Praziquantel analogues: Potential candidates for the treatment of schistosomiasis/doi:10.1016%2Fj.bmcl.2011.11.108/rivista:Bioorganic & medicinal chemistry letters (Print)/anno:2012/pagina_da:1103/pagina_a:1106/intervallo_pagine:1103–1106/volume:22
22 (2012): 1103–1106. doi:10.1016/j.bmcl.2011.11.108
info:cnr-pdr/source/autori:Partha Sarathi Sadhu a; Singam Naveen Kumar a; Malapaka Chandrasekharam b; Livia Pica-Mattoccia c; Donato Cioli c; Vaidya Jayathirtha Rao a/titolo:Synthesis of new Praziquantel analogues: Potential candidates for the treatment of schistosomiasis/doi:10.1016%2Fj.bmcl.2011.11.108/rivista:Bioorganic & medicinal chemistry letters (Print)/anno:2012/pagina_da:1103/pagina_a:1106/intervallo_pagine:1103–1106/volume:22
An efficient synthesis of antischistosomal drug praziquantel and analogues was achieved and the synthetic route designed was to afford structurally diverse analogues for better structure–activity relationship understanding. Total of nineteen PZQ an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4909e3bd8994cb2dfec42a998a2719d4
https://doi.org/10.1016/j.bmcl.2011.11.108
https://doi.org/10.1016/j.bmcl.2011.11.108
Autor:
Piero Liberti, Tiziana Orsini, Cristiana Valle, Livia Pica-Mattoccia, Annalisa Basso, Sonia Nobre-Santana, Ana-Luiza Marcatto-Maggi, Alfredo Festucci, Alessandra Guidi, Donato Cioli, Anna-Rita Troiani
Publikováno v:
Experimental parasitology 119 (2008): 332–335. doi:10.1016/j.exppara.2008.03.012
info:cnr-pdr/source/autori:Pica-Mattoccia L, Orsini T, Basso A, Festucci A, Liberti P, Guidi A, Marcatto-Maggi AL, Nobre-Santana S, Troiani AR, Cioli D, Valle C./titolo:Schistosoma mansoni: lack of correlation between praziquantel-induced intra-worm calcium influx and parasite death./doi:10.1016%2Fj.exppara.2008.03.012/rivista:Experimental parasitology/anno:2008/pagina_da:332/pagina_a:335/intervallo_pagine:332–335/volume:119
info:cnr-pdr/source/autori:Pica-Mattoccia L, Orsini T, Basso A, Festucci A, Liberti P, Guidi A, Marcatto-Maggi AL, Nobre-Santana S, Troiani AR, Cioli D, Valle C./titolo:Schistosoma mansoni: lack of correlation between praziquantel-induced intra-worm calcium influx and parasite death./doi:10.1016%2Fj.exppara.2008.03.012/rivista:Experimental parasitology/anno:2008/pagina_da:332/pagina_a:335/intervallo_pagine:332–335/volume:119
The schistosomicidal activity of praziquantel (PZQ) is accompanied by a large influx of calcium into the worms, suggesting that this phenomenon could be the source of the observed muscular contraction, surface disruption and eventual death of the par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37504f53b1b8269b35f7c9b868a385fa
https://doi.org/10.1016/j.exppara.2008.03.012
https://doi.org/10.1016/j.exppara.2008.03.012
Autor:
Donato Cioli, Xia Chao-Ming, Livia Pica-Mattoccia, Matthew H. Todd, A. Venkata Ramana, Fiona Ronketti
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4154-4157
Several analogues of the potent anthelmintic praziquantel were prepared with variation in the aromatic ring. The biological activity of these analogues was evaluated and compared against known analogues. Amination of the ring was tolerated while othe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94747790e4580fbd158b2ff21d79b45b
https://doi.org/10.1016/j.bmcl.2007.05.063
https://doi.org/10.1016/j.bmcl.2007.05.063
Autor:
Anna Rita Troiani, Donato Cioli, Livia Pica-Mattoccia, Alfredo Festucci, Piero Liberti, Cristiana Valle, Annalisa Basso, Fabio Vigorosi
Publikováno v:
Experimental parasitology 115 (2007): 344–351. doi:10.1016/j.exppara.2006.09.017
info:cnr-pdr/source/autori:Pica-Mattoccia L., Valle C., Basso A., Troiani A.R., Vigorosi F., Liberti P., Festucci A. and Cioli D./titolo:Cytochalasin D abolishes the schistosomicidal activity of praziquantel./doi:10.1016%2Fj.exppara.2006.09.017/rivista:Experimental parasitology/anno:2007/pagina_da:344/pagina_a:351/intervallo_pagine:344–351/volume:115
info:cnr-pdr/source/autori:Pica-Mattoccia L., Valle C., Basso A., Troiani A.R., Vigorosi F., Liberti P., Festucci A. and Cioli D./titolo:Cytochalasin D abolishes the schistosomicidal activity of praziquantel./doi:10.1016%2Fj.exppara.2006.09.017/rivista:Experimental parasitology/anno:2007/pagina_da:344/pagina_a:351/intervallo_pagine:344–351/volume:115
To test the hypothesis that calcium channels of schistosomes are the targets for the action of praziquantel, we subjected schistosomes in vitro to pharmacological agents capable of interfering with the functioning of calcium channels. After 1-h expos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e2df21234c8812756d734393bc4da2
https://doi.org/10.1016/j.exppara.2006.09.017
https://doi.org/10.1016/j.exppara.2006.09.017
Publikováno v:
International Journal for Parasitology. 35:1453-1457
Schistosoma mansoni is known to be refractory to praziquantel treatment in the pre-patent period of infection. Since Schistosoma haematobium has a much longer pre-patent period (10-12 weeks vs. 5-6 for the former species), we asked the question wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f542f7b3903c91f1a0b2e9cc1a36149
https://doi.org/10.1016/j.ijpara.2005.05.002
https://doi.org/10.1016/j.ijpara.2005.05.002