Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Livia Lopez Noriega"'
Autor:
Roderick C. Slieker, Louise A. Donnelly, Elina Akalestou, Livia Lopez-Noriega, Rana Melhem, Ayşim Güneş, Frederic Abou Azar, Alexander Efanov, Eleni Georgiadou, Hermine Muniangi-Muhitu, Mahsa Sheikh, Giuseppe N. Giordano, Mikael Åkerlund, Emma Ahlqvist, Ashfaq Ali, Karina Banasik, Søren Brunak, Marko Barovic, Gerard A. Bouland, Frédéric Burdet, Mickaël Canouil, Iulian Dragan, Petra J. M. Elders, Celine Fernandez, Andreas Festa, Hugo Fitipaldi, Phillippe Froguel, Valborg Gudmundsdottir, Vilmundur Gudnason, Mathias J. Gerl, Amber A. van der Heijden, Lori L. Jennings, Michael K. Hansen, Min Kim, Isabelle Leclerc, Christian Klose, Dmitry Kuznetsov, Dina Mansour Aly, Florence Mehl, Diana Marek, Olle Melander, Anne Niknejad, Filip Ottosson, Imre Pavo, Kevin Duffin, Samreen K. Syed, Janice L. Shaw, Over Cabrera, Timothy J. Pullen, Kai Simons, Michele Solimena, Tommi Suvitaival, Asger Wretlind, Peter Rossing, Valeriya Lyssenko, Cristina Legido Quigley, Leif Groop, Bernard Thorens, Paul W. Franks, Gareth E. Lim, Jennifer Estall, Mark Ibberson, Joline W. J. Beulens, Leen M ’t Hart, Ewan R. Pearson, Guy A. Rutter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2-aminoadipic acid, eight triacyl
Externí odkaz:
https://doaj.org/article/8eb84b4a486246dfb262ac9be25f0911
Autor:
Elina Akalestou, Kinga Suba, Livia Lopez-Noriega, Eleni Georgiadou, Pauline Chabosseau, Alasdair Gallie, Asger Wretlind, Cristina Quigley, Isabelle Leclerc, Victoria Salem, Guy A. Rutter
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Bariatric surgery procedures reduce weight and improve metabolic diseases. Here the authors investigate the effects of Vertical Sleeve Gastrectomy (VSG) on beta-cell function in mice using in vivo Ca2 + imaging and show that VSG increases beta-cell f
Externí odkaz:
https://doaj.org/article/8883f2819a32466d8fcddbfc90b52f1e
Autor:
Elina Akalestou, Livia Lopez-Noriega, Ioannis Christakis, Ming Hu, Alexander D. Miras, Isabelle Leclerc, Guy A. Rutter
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
ObjectivesGlucocorticoids produced by the adrenal cortex are essential for the maintenance of metabolic homeostasis. Glucocorticoid activation is catalysed by 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1). Excess glucocorticoids are associated with
Externí odkaz:
https://doaj.org/article/715c140078e94857a79ede4b72cc3d99
Autor:
Elina Akalestou, Kinga Suba, Livia Lopez-Noriega, Eleni Georgiadou, Pauline Chabosseau, Alasdair Gallie, Asger Wretlind, Cristina Legido-Quigley, Isabelle Leclerc, Victoria Salem, Guy A. Rutter
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/c286f4e96f8148e0ae12a0a2035467e5
Autor:
Elina Akalestou, Livia Lopez-Noriega, Iain R. Tough, Ming Hu, Isabelle Leclerc, Helen M. Cox, Guy A. Rutter
Publikováno v:
Diabetes. 71:1623-1635
Bariatric surgery improves glucose homeostasis but the underlying mechanisms are not fully elucidated. Here, we show that the expression of sodium glucose cotransporter-2 (SGLT2/Slc5a2) is reduced in the kidney of lean and obese mice following vertic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014afd61f26a8b24f371277db6399253
https://doi.org/10.2337/db21-0768
https://doi.org/10.2337/db21-0768
Autor:
Marie-Sophie Nguyen-Tu, Joseph Harris, Aida Martinez-Sanchez, Pauline Chabosseau, Ming Hu, Eleni Georgiadou, Alice Pollard, Pablo Otero, Livia Lopez-Noriega, Isabelle Leclerc, Kei Sakamoto, Dieter Schmoll, David M. Smith, David Carling, Guy A. Rutter
Publikováno v:
Nguyen-Tu, M-S, Harris, J, Martinez-Sanchez, A, Chabosseau, P, Hu, M, Georgiadou, E, Pollard, A, Otero, P, Lopez-Noriega, L, Leclerc, I, Sakamoto, K, Schmoll, D, Smith, D M, Carling, D & Rutter, G A 2022, ' Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase ', Diabetologia, vol. 65, pp. 997-1011 . https://doi.org/10.1007/s00125-022-05673-x
Aims/hypothesis Although targeted in extrapancreatic tissues by several drugs used to treat type 2 diabetes, the role of AMP-activated protein kinase (AMPK) in the control of insulin secretion is still debatable. Previous studies have used pharmacolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6227421373a23cecf46c480007056b6b
https://doi.org/10.1007/s00125-022-05673-x
https://doi.org/10.1007/s00125-022-05673-x
Autor:
Pauline Chabosseau, Fiona Yong, Luis F. Delgadillo-Silva, Eun Young Lee, Shiying Li, Nidhi Gandhi, Jules Wastin, Livia Lopez Noriega, Isabelle Leclerc, Yusuf Ali, Jing W. Hughes, Robert Sladek, Aida Martinez-Sanchez, Guy A. Rutter
AimsSpatially-organised increases in cytosolic Ca2+within pancreatic beta cells in the pancreatic islet underlie the stimulation of insulin secretion by high glucose. Recent data have revealed the existence of subpopulations of beta cells including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9756a07065abc332431493923c8653a
https://doi.org/10.1101/2022.08.26.505442
https://doi.org/10.1101/2022.08.26.505442
Autor:
Eleni Georgiadou, Charanya Muralidharan, Michelle Martinez, Pauline Chabosseau, Elina Akalestou, Alejandra Tomas, Fiona Yong Su Wern, Theodoros Stylianides, Asger Wretlind, Cristina Legido-Quigley, Ben Jones, Livia Lopez-Noriega, Yanwen Xu, Guoqiang Gu, Nour Alsabeeh, Céline Cruciani-Guglielmacci, Christophe Magnan, Mark Ibberson, Isabelle Leclerc, Yusuf Ali, Scott A. Soleimanpour, Amelia K. Linnemann, Tristan A. Rodriguez, Guy A. Rutter
Mitochondrial glucose metabolism is essential for stimulated insulin release from pancreatic β-cells. Whether mitofusin gene expression, and hence, mitochondrial network integrity, is important for glucose or incretin signaling has not previously be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::782a4497e12f573a03c20d9c8789e64f
https://doi.org/10.2337/figshare.19607232
https://doi.org/10.2337/figshare.19607232
Autor:
Pauline Chabosseau, Fiona Yong, Luis F. Delgadillo-Silva, Eun Young Lee, Rana Melhem, Shiying Li, Nidhi Gandhi, Jules Wastin, Livia Lopez Noriega, Isabelle Leclerc, Yusuf Ali, Jing W. Hughes, Robert Sladek, Aida Martinez-Sanchez, Guy A. Rutter
Publikováno v:
Life Sciences. 316:121436
AIMS: Spatially-organized increases in cytosolic Ca2+ within pancreatic beta cells in the pancreatic islet underlie the stimulation of insulin secretion by high glucose. Recent data have revealed the existence of subpopulations of beta cells includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553e1879d5083e8e5a9161b9136b31ad
https://doi.org/10.1016/j.lfs.2023.121436
https://doi.org/10.1016/j.lfs.2023.121436
Autor:
Kinga Suba, Victoria Salem, Guy A. Rutter, Elina Akalestou, Asger Wretlind, Eleni Georgiadou, Isabelle Leclerc, Pauline Chabosseau, Alasdair Gallie, Livia Lopez-Noriega, Cristina Legido-Quigley
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Bariatric surgery improves both insulin sensitivity and secretion and can induce diabetes remission. However, the mechanisms and time courses of these changes, particularly the impact on β cell function, are difficult to monitor directly. In this st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a42ee6e76d2606df8388d47f6ba5744e
http://europepmc.org/articles/PMC8397709
http://europepmc.org/articles/PMC8397709