Targeting virulence regulation to disarm Acinetobacter baumannii pathogenesis

Autor: Vincent Trebosc, Valentina Lucchini, Mohit Narwal, Basil Wicki, Sarah Gartenmann, Birgit Schellhorn, Julian Schill, Marilyne Bourotte, Daniel Frey, Jürgen Grünberg, Andrej Trauner, Livia Ferrari, Antonio Felici, Olivia L. Champion, Marc Gitzinger, Sergio Lociuro, Richard A. Kammerer, Christian Kemmer, Michel Pieren

Publikováno v: Virulence, Vol 13, Iss 1, Pp 1868-1883 (2022)

The development of anti-virulence drug therapy against Acinetobacter baumannii infections would provide an alternative to traditional antibacterial therapy that are increasingly failing. Here, we demonstrate that the OmpR transcriptional regulator pl

Externí odkaz: https://doaj.org/article/15918578828b477baf8ad5a55dd06209

A Niclosamide-releasing hot-melt extruded catheter prevents Staphylococcus aureus experimental biomaterial-associated infection

Autor: Jesus Augusto Vazquez-Rodriguez, Bahaa Shaqour, Clara Guarch-Pérez, Emilia Choińska, Martijn Riool, Bart Verleije, Koen Beyers, Vivian J. A. Costantini, Wojciech Święszkowski, Sebastian A. J. Zaat, Paul Cos, Antonio Felici, Livia Ferrari

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)

Abstract Biomaterial-associated infections are a major healthcare challenge as they are responsible for high disease burden in critically ill patients. In this study, we have developed drug-eluting antibacterial catheters to prevent catheter-related

Externí odkaz: https://doaj.org/article/063a964a93684d7aa1e518dfdf52a798

OMN6 a novel bioengineered peptide for the treatment of multidrug resistant Gram negative bacteria

Autor: Shira Mandel, Janna Michaeli, Noa Nur, Isabelle Erbetti, Jonathan Zazoun, Livia Ferrari, Antonio Felici, Moshe Cohen-Kutner, Niv Bachnoff

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract New antimicrobial agents are urgently needed, especially to eliminate multidrug resistant Gram-negative bacteria that stand for most antibiotic-resistant threats. In the following study, we present superior properties of an engineered antimi

Externí odkaz: https://doaj.org/article/83a72ed367e14c80809b6afdced28df3

Mouse pneumonia model by Acinetobacter baumannii multidrug resistant strains: Comparison between intranasal inoculation, intratracheal instillation and oropharyngeal aspiration techniques.

Autor: Gabriella Bergamini, Maria Elisa Perico, Stefano Di Palma, Daniela Sabatini, Filippo Andreetta, Rossella Defazio, Antonio Felici, Livia Ferrari

Publikováno v: PLoS ONE, Vol 16, Iss 12, p e0260627 (2021)

Infectious pneumonia induced by multidrug resistant (MDR) Acinetobacter baumannii strains is among the most common and deadly forms of healthcare acquired infections. Over the years, different strategies have been put in place to increase host suscep

Externí odkaz: https://doaj.org/article/1c83d24284dd4e21a3546837535c1741

Interlaboratory study for the evaluation of three microtiter plate-based biofilm quantification methods

Autor: Antonio Felici, Frits van Charante, Darla M. Goeres, Paul Cos, Inés Reigada, Sebastian A. J. Zaat, Livia Ferrari, Jesus Augusto Vazquez-Rodriguez, Albert E. Parker, Tom Coenye, Adyary Fallarero, Clara Guarch-Pérez, Jontana Allkja, Nuno F. Azevedo, Juliana Aizawa

Publikováno v: Scientific reports, 11(1):13779. Nature Publishing Group
Scientific Reports
Scientific reports
SCIENTIFIC REPORTS
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)

Microtiter plate methods are commonly used for biofilm assessment. However, results obtained with these methods have often been difficult to reproduce. Hence, it is important to obtain a better understanding of the repeatability and reproducibility o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc52ce9b27e92567cdd7af12e9064f6
https://pure.amc.nl/en/publications/interlaboratory-study-for-the-evaluation-of-three-microtiter-platebased-biofilm-quantification-methods(255f5819-f41b-4aee-bd4c-6a698493d7f4).html