Precancerous liver diseases do not cause increased mutagenesis in liver stem cells

Autor: Ruben van Boxtel, Nicolle Besselink, Mauro D. Locati, Sander Boymans, Ruby Lieshout, Roel Janssen, Luan Nguyen, Michail Doukas, Myrthe Jager, Ewart W. Kuijk, Edwin Cuppen, Luc J. W. van der Laan, Jeroen de Jonge, Bastiaan van der Roest, Jan N. M. IJzermans, Petra E. de Ruiter, Monique M A Verstegen

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Communications Biology, 4(1):1301. Springer Nature
Communications Biology

Inflammatory liver disease increases the risk of developing primary liver cancer. The mechanism through which liver disease induces tumorigenesis remains unclear, but is thought to occur via increased mutagenesis. Here, we performed whole-genome sequ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a43ac1047b60b049f8ee5bc74e77e882
https://doaj.org/article/96839cce3bec43feb376e5547a803268

Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease

Autor: Verstegen, Monique M A, Roos, Floris J M, Burka, Ksenia, Gehart, Helmuth, Jager, Myrthe, de Wolf, Maaike, Bijvelds, Marcel J C, de Jonge, Hugo R, Ardisasmita, Arif I, van Huizen, Nick A, Roest, Henk P, de Jonge, Jeroen, Koch, Michael, Pampaloni, Francesco, Fuchs, Sabine A, Schene, Imre F, Luider, Theo M, van der Doef, Hubert P J, Bodewes, Frank A J A, de Kleine, Ruben H J, Spee, Bart, Kremers, Gert-Jan, Clevers, Hans, IJzermans, Jan N M, Cuppen, Edwin, van der Laan, Luc J W, Interne geneeskunde GD, dCSCA RMSC-1, Sub SBR overig, Faculteit Diergeneeskunde, Dep Biologie, CS_STEM

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports, 10(1):21900. Nature Publishing Group
Scientific Reports, 10(1). Nature Publishing Group
Scientific Reports, 10(1). NLM (Medline)
Scientific Reports

The development, homeostasis, and repair of intrahepatic and extrahepatic bile ducts are thought to involve distinct mechanisms including proliferation and maturation of cholangiocyte and progenitor cells. This study aimed to characterize human extra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be6f010f1aa6e0ac8ce7c76b8cec33f6
https://doaj.org/article/eb9e7d98f7234f40b94f21db6d99f8db

Transplantable Liver Organoids, Too Many Cell Types to Choose: a Need for Scientific Self-Organization

Autor: Louis C. Penning, Pedro M. Baptista

Publikováno v: Current Transplantation Reports. 7:18-23

Purpose of Review Liver stem cells have been proposed as alternatives or additions for whole liver transplantations to accommodate the donor liver shortage. Various sources of liver stem cells have been described in experimental animal studies. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43390a16343d8f1af4c1caf16fbe0d5c
https://doi.org/10.1007/s40472-020-00266-2

MODERN VIEWS ON LIVER STEM CELLS AND THEIR OCCUPIED NICHES

Autor: Elena Ivanovna Lebedeva, Anatoly Tadeushevich Shchastny

Publikováno v: The European Journal of Biomedical and Life Sciences. :32-36

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e04a25707a39eb58102b1d39f4cb59c
https://doi.org/10.29013/elbls-20-2.3-32-36

Hepatitis C Virus Infects and Perturbs Liver Stem Cells

Autor: Tal Ashuach, Danielle E Lyons, Jody L. Baron, Norma Neff, Mir M. Khalid, Camille R. Simoneau, Vaishaali Natarajan, Nir Yosef, Ann L Erickson, Thong T. Nguyen, Taha Y. Taha, Fabio Zanini, Stephen R. Quake, Melanie Ott, Nevan J. Krogan, Nathan L. Meyers, Mehdi Bouhaddou, Stewart Cooper, Todd C. McDevitt, Tokameh Mahmoud

SummaryHepatitis C virus (HCV) is the leading cause of death from liver disease. How HCV infection causes lasting liver damage and increases cancer risk beyond viral clearance remains unclear. We identify bipotent liver stem cells as novel targets fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fed562a55c68545f0eec40634225dba6
https://doi.org/10.1101/2021.10.26.465357