A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity

Autor: Natascha Roehlen, Antonio Saviano, Houssein El Saghire, Emilie Crouchet, Zeina Nehme, Fabio Del Zompo, Frank Jühling, Marine A. Oudot, Sarah C. Durand, François H. T. Duong, Sara Cherradi, Victor Gonzalez Motos, Nuno Almeida, Clara Ponsolles, Laura Heydmann, Tessa Ostyn, Antonin Lallement, Patrick Pessaux, Emanuele Felli, Andrea Cavalli, Jacopo Sgrignani, Christine Thumann, Olga Koutsopoulos, Bryan C. Fuchs, Yujin Hoshida, Maike Hofmann, Mogens Vyberg, Birgitte Martine Viuff, Elisabeth D. Galsgaard, Greg Elson, Alberto Toso, Markus Meyer, Roberto Iacone, Tamas Schweighoffer, Geoffrey Teixeira, Solange Moll, Claudio De Vito, Tania Roskams, Irwin Davidson, Danijela Heide, Mathias Heikenwälder, Mirjam B. Zeisel, Joachim Lupberger, Laurent Mailly, Catherine Schuster, Thomas F. Baumert

Publikováno v: Roehlen, N, Saviano, A, El Saghire, H, Crouchet, E, Nehme, Z, Del Zompo, F, Jühling, F, Oudot, M A, Durand, S C, Duong, F H T, Cherradi, S, Gonzalez Motos, V, Almeida, N, Ponsolles, C, Heydmann, L, Ostyn, T, Lallement, A, Pessaux, P, Felli, E, Cavalli, A, Sgrignani, J, Thumann, C, Koutsopoulos, O, Fuchs, B C, Hoshida, Y, Hofmann, M, Vyberg, M, Viuff, B M, Galsgaard, E D, Elson, G, Toso, A, Meyer, M, Iacone, R, Schweighoffer, T, Teixeira, G, Moll, S, De Vito, C, Roskams, T, Davidson, I, Heide, D, Heikenwälder, M, Zeisel, M B, Lupberger, J, Mailly, L, Schuster, C & Baumert, T F 2022, ' A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity ', Science Translational Medicine, vol. 14, no. 676, eabj4221, pp. eabj4221 . https://doi.org/10.1126/scitranslmed.abj4221

Tissue fibrosis is a key driver of end-stage organ failure and cancer, overall accounting for up to 45% of deaths in developed countries. There is a large unmet medical need for antifibrotic therapies. Claudin-1 (CLDN1) is a member of the tight junct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a15761706f515b3e02c2102683616d7
https://vbn.aau.dk/da/publications/ae147006-4f6f-4e57-bf99-f23fc8da0fa9

A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis

Autor: Jacob George, Philip Newsome, Henning Grønbæk, Manuel Romero-Gómez, Syed-Mohammed Jafri, Lynsey Corless, Joanna Uddén Hemmingsson, Rodolphe Anty, Jude Oben, Vlad Ratziu, Maeva Guillaume

Publikováno v: Newsome, P N, Buchholtz, K, Cusi, K, Linder, M, Okanoue, T, Ratziu, V, Sanyal, A J, Sejling, A-S, Harrison, S A & NN9931-4296 Investigators 2021, ' A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis ', The New England Journal of Medicine, vol. 384, no. 12, pp. 1113-1124 . https://doi.org/10.1056/NEJMoa2028395

BACKGROUND: Nonalcoholic steatohepatitis (NASH) is a common disease that is associated with increased morbidity and mortality, but treatment options are limited. The efficacy and safety of the glucagon-like peptide-1 receptor agonist semaglutide in p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cee5c2fb724a8dcdcd7dc228bf819a3
https://doi.org/10.1056/nejmoa2028395

Randomised clinical study::acute effects of metformin versus placebo on portal pressure in patients with cirrhosis and portal hypertension

Autor: Nikolaj Rittig, Gerda Elisabeth Villadsen, Henning Grønbæk, Niels Kristian Aagaard, Niels Jessen, Jacob George, Thomas Damgaard Sandahl

Publikováno v: Rittig, N, Aagaard, N K, Villadsen, G E, Sandahl, T D, Jessen, N, Grønbaek, H & George, J 2021, ' Randomised clinical study: acute effects of metformin versus placebo on portal pressure in patients with cirrhosis and portal hypertension ', Alimentary Pharmacology and Therapeutics, vol. 54, no. 3, pp. 320-328 . https://doi.org/10.1111/apt.16460

BACKGROUND: Portal hypertension is the main determinant of clinical decompensation in patients with liver cirrhosis. In preclinical data metformin lowers portal pressure, but there are no clinical data for this beneficial effect.AIMS: To investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b667200251c5aac4ba47acda75a5a3bb
https://pure.au.dk/portal/da/publications/randomised-clinical-study(6e73e0e8-cf64-4cde-9d48-a0da7646310e).html

Role of the nuclear factor-kappa B signaling pathway on the progress of hepatic fibrosis and the anti-fibrotic mechanism of traditional Chinese medicine

Autor: ZHU Hui, PING Jian, XU Lieming

Publikováno v: Linchuang Gandanbing Zazhi, Vol 34, Iss 4, Pp 858-861 (2018)

Nuclear factor-kappa B (NF-κB) plays an important role in various physiological and pathological processes by regulating gene expression, such as cell survival, growth, proliferation, activation, and apoptosis. In particular, the NF-κB signaling pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::80d909f1e7d20c8ec7fbc48204a6307d
http://www.lcgdbzz.org/qk_content.asp?id=8915

Rifaximin has minor effects on bacterial composition, inflammation and bacterial translocation in cirrhosis:A randomized trial

Autor: Kimer, Nina, Pedersen, Julie S, Tavenier, Juliette, Christensen, Jeffrey E, Busk, Troels Malte, Hobolth, Lise, Krag, Aleksander, Al-Soud, Waleed Abu, Mortensen, Martin S, Sørensen, Søren J., Møller, Søren, Bendtsen, Flemming

Publikováno v: Kimer, N, Pedersen, J S, Tavenier, J, Christensen, J E, Busk, T M, Hobolth, L, Krag, A, Al-Soud, W A, Mortensen, M S, Sørensen, S J, Møller, S, Bendtsen, F & And members of the CoRif study group 2018, ' Rifaximin has minor effects on bacterial composition, inflammation and bacterial translocation in cirrhosis : A randomized trial ', Journal of Gastroenterology and Hepatology, vol. 33, no. 1, pp. 307–314 . https://doi.org/10.1111/jgh.13852

Background and Aim: Decompensated cirrhosis is characterized by disturbed hemodynamics, immune dysfunction, and high risk of infections. Translocation of viable bacteria and bacterial products from the gut to the blood is considered a key driver in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3062::44f1b7886ab6ea0d005bb7282850ee86
https://findresearcher.sdu.dk:8443/ws/files/129514142/Rifaximin_has_minor_effects_on_bacterial_composition_inflammation_and_bacterial_translocation_in_cirrhosi.pdf