Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Liver Cirrhosis / drug therapy"'
Autor:
Natascha Roehlen, Antonio Saviano, Houssein El Saghire, Emilie Crouchet, Zeina Nehme, Fabio Del Zompo, Frank Jühling, Marine A. Oudot, Sarah C. Durand, François H. T. Duong, Sara Cherradi, Victor Gonzalez Motos, Nuno Almeida, Clara Ponsolles, Laura Heydmann, Tessa Ostyn, Antonin Lallement, Patrick Pessaux, Emanuele Felli, Andrea Cavalli, Jacopo Sgrignani, Christine Thumann, Olga Koutsopoulos, Bryan C. Fuchs, Yujin Hoshida, Maike Hofmann, Mogens Vyberg, Birgitte Martine Viuff, Elisabeth D. Galsgaard, Greg Elson, Alberto Toso, Markus Meyer, Roberto Iacone, Tamas Schweighoffer, Geoffrey Teixeira, Solange Moll, Claudio De Vito, Tania Roskams, Irwin Davidson, Danijela Heide, Mathias Heikenwälder, Mirjam B. Zeisel, Joachim Lupberger, Laurent Mailly, Catherine Schuster, Thomas F. Baumert
Publikováno v:
Roehlen, N, Saviano, A, El Saghire, H, Crouchet, E, Nehme, Z, Del Zompo, F, Jühling, F, Oudot, M A, Durand, S C, Duong, F H T, Cherradi, S, Gonzalez Motos, V, Almeida, N, Ponsolles, C, Heydmann, L, Ostyn, T, Lallement, A, Pessaux, P, Felli, E, Cavalli, A, Sgrignani, J, Thumann, C, Koutsopoulos, O, Fuchs, B C, Hoshida, Y, Hofmann, M, Vyberg, M, Viuff, B M, Galsgaard, E D, Elson, G, Toso, A, Meyer, M, Iacone, R, Schweighoffer, T, Teixeira, G, Moll, S, De Vito, C, Roskams, T, Davidson, I, Heide, D, Heikenwälder, M, Zeisel, M B, Lupberger, J, Mailly, L, Schuster, C & Baumert, T F 2022, ' A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity ', Science Translational Medicine, vol. 14, no. 676, eabj4221, pp. eabj4221 . https://doi.org/10.1126/scitranslmed.abj4221
Tissue fibrosis is a key driver of end-stage organ failure and cancer, overall accounting for up to 45% of deaths in developed countries. There is a large unmet medical need for antifibrotic therapies. Claudin-1 (CLDN1) is a member of the tight junct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a15761706f515b3e02c2102683616d7
https://vbn.aau.dk/da/publications/ae147006-4f6f-4e57-bf99-f23fc8da0fa9
https://vbn.aau.dk/da/publications/ae147006-4f6f-4e57-bf99-f23fc8da0fa9
Autor:
Cas J. Isfordink, Marleen van Dijk, Sylvia M. Brakenhoff, Patricia A.M. Kracht, Joop E. Arends, Robert J. de Knegt, Marc van der Valk, Joost P.H. Drenth, M. van den Berg, P. Honkoop, S. Abraham, S. Bosman, P. van Wijngaarden, K. Steenhuisen, P. Friederich, A.S. M. Dofferhoff, J. Berkhout, F. ter Borg, J.M. da Silva, M.A.M.T. Verhagen, X. Vos, K. Vlaar, R. Douma, W.G. Erkelen, M. den Reijer, C.J.P.A. Hoebe, J. Heil, M. Baven, H. van Soest, K. Sebib Korkmaz, G. Bezemer, A.J.J. Lammers, S.B. Debast, H.J.M. de Jong, P. Bus, P. Sturm, J. den Hollander, L.M. Kampschreur, N. Venneman, F. Bosma, O.M. Koc, R. Ackens, E. van Oorschot, M. Klemt-Kropp, L.C. Baak, J.T. Brouwer, B.W.M. Spanier, C. Swanink, H. Blokzijl, M. Knoester, P. Liedorp, J. van Bergeijk, A. van Nunen
Publikováno v:
European journal of internal medicine, 101, 93-97. Elsevier Science
European Journal of Internal Medicine, 101, pp. 93-97
European journal of internal medicine, 101, 93-97. Elsevier
European Journal of Internal Medicine, 101, 93-97. ELSEVIER SCIENCE BV
European Journal of Internal Medicine, 101, 93-97
European Journal of Internal Medicine, 101, 93-97. Elsevier
European Journal of Internal Medicine, 101, pp. 93-97
European journal of internal medicine, 101, 93-97. Elsevier
European Journal of Internal Medicine, 101, 93-97. ELSEVIER SCIENCE BV
European Journal of Internal Medicine, 101, 93-97
European Journal of Internal Medicine, 101, 93-97. Elsevier
Contains fulltext : 252163.pdf (Publisher’s version ) (Open Access) BACKGROUND & AIMS: The number of chronic hepatitis C virus (HCV)-infected patients who have been lost to follow-up (LTFU) is high and threatens HCV elimination. Micro-elimination f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8314930152d301bd4aed6c5cba90f1d8
https://cris.maastrichtuniversity.nl/en/publications/a01f1ffa-f2af-4cd1-a333-56362f481d9e
https://cris.maastrichtuniversity.nl/en/publications/a01f1ffa-f2af-4cd1-a333-56362f481d9e
Autor:
Jacob George, Philip Newsome, Henning Grønbæk, Manuel Romero-Gómez, Syed-Mohammed Jafri, Lynsey Corless, Joanna Uddén Hemmingsson, Rodolphe Anty, Jude Oben, Vlad Ratziu, Maeva Guillaume
Publikováno v:
Newsome, P N, Buchholtz, K, Cusi, K, Linder, M, Okanoue, T, Ratziu, V, Sanyal, A J, Sejling, A-S, Harrison, S A & NN9931-4296 Investigators 2021, ' A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis ', The New England Journal of Medicine, vol. 384, no. 12, pp. 1113-1124 . https://doi.org/10.1056/NEJMoa2028395
BACKGROUND: Nonalcoholic steatohepatitis (NASH) is a common disease that is associated with increased morbidity and mortality, but treatment options are limited. The efficacy and safety of the glucagon-like peptide-1 receptor agonist semaglutide in p
Autor:
Pose, Elisa, Solà, Elsa, Lozano, Juan J., Juanola, Adrià, Sidorova, Julia, Zaccherini, Giacomo, Wit, Koos, Uschner, Frank, Tonon, Marta, Kazankov, Konstantin, Jiménez, Cesar, Campion, Daniela, Napoleone, Laura, Ma, Ann T., Carol, Marta, Morales‐Ruiz, Manuel, Alessandria, Carlo, Beuers, Ulrich, Caraceni, Paolo, Francoz, Claire, Durand, François, Mookerjee, Rajeshwar P., Trebicka, Jonel, Vargas, Victor, Piano, Salvatore, Watson, Hugh, Abraldes, Juan G., Kamath, Patrick S., Davis, Mark M., Ginès, Pere, Schulz, M., Ferstl, P., Giovo, I., Roux, O., Simon‐Talero, M., Pérez‐Guasch, M., Rubio, A.B., Cervera, M., Martínez, S., Fabrellas, N., Pich, J., Vives, A., Avitabile, E., Graupera, I., Solé, C., Bassegoda, O., Gratacós‐Ginès, J., Joyera, M., Palacio, E., Aban, M., Lanzillotti, T., Nicolao, G., Chiappa, M.T., Esnault, V., Andrade, R., Pavesi, M., Korenjak, M., Farrés, J., Serra‐Burriel, M., Angeli, P.
Publikováno v:
Pose, E, Solà, E, Lozano, J J, Juanola, A, Sidorova, J, Zaccherini, G, de Wit, K, Uschner, F, Tonon, M, Kazankov, K, Jiménez, C, Campion, D, Napoleone, L, Ma, A T, Carol, M, Morales-Ruiz, M, Alessandria, C, Beuers, U, Caraceni, P, Francoz, C, Durand, F, Mookerjee, R P, Trebicka, J, Vargas, V, Piano, S, Watson, H, Abraldes, J G, Kamath, P S, Davis, M M, Ginès, P & investigators of the LIVERHOPE Consortium 2022, ' Treatment With Simvastatin and Rifaximin Restores the Plasma Metabolomic Profile in Patients With Decompensated Cirrhosis ', Hepatology Communications, vol. 6, no. 5, pp. 1100-1112 . https://doi.org/10.1002/hep4.1881
Hepatol Commun
Hepatology communications. Wiley-Blackwell Publishing Ltd
Hepatol Commun
Hepatology communications. Wiley-Blackwell Publishing Ltd
Patients with decompensated cirrhosis, particularly those with acute-on-chronic liver failure (ACLF), show profound alterations in plasma metabolomics. The aim of this study was to investigate the effect of treatment with simvastatin and rifaximin on
Autor:
Nikolaj Rittig, Gerda Elisabeth Villadsen, Henning Grønbæk, Niels Kristian Aagaard, Niels Jessen, Jacob George, Thomas Damgaard Sandahl
Publikováno v:
Rittig, N, Aagaard, N K, Villadsen, G E, Sandahl, T D, Jessen, N, Grønbaek, H & George, J 2021, ' Randomised clinical study: acute effects of metformin versus placebo on portal pressure in patients with cirrhosis and portal hypertension ', Alimentary Pharmacology and Therapeutics, vol. 54, no. 3, pp. 320-328 . https://doi.org/10.1111/apt.16460
BACKGROUND: Portal hypertension is the main determinant of clinical decompensation in patients with liver cirrhosis. In preclinical data metformin lowers portal pressure, but there are no clinical data for this beneficial effect.AIMS: To investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b667200251c5aac4ba47acda75a5a3bb
https://pure.au.dk/portal/da/publications/randomised-clinical-study(6e73e0e8-cf64-4cde-9d48-a0da7646310e).html
https://pure.au.dk/portal/da/publications/randomised-clinical-study(6e73e0e8-cf64-4cde-9d48-a0da7646310e).html
Autor:
Saeed Shoaie, Sidsel Støy, Stanislav Dusko Ehrlich, Selin Gencer, Susie Guilly, Godhev K. Manakkat Vijay, Thomas H. Tranah, Mark J. W. McPhail, Ane Zamalloa, Lindsey A. Edwards, Muireann Coen, Xaiohong Huang, Nicolas Pons, Nathalie Galleron, Julia Wendon, Kenneth D. Bruce, Vishal C. Patel, Sunjae Lee, Debbie L. Shawcross, Elizabeth A. Witherden, K. J. D. e Silva
Publikováno v:
Patel, V C, Lee, S, McPhail, M J W, Da Silva, K, Guilly, S, Zamalloa, A, Witherden, E, Støy, S, Manakkat Vijay, G K, Pons, N, Galleron, N, Huang, X, Gencer, S, Coen, M, Tranah, T H, Wendon, J A, Bruce, K D, Le Chatelier, E, Ehrlich, S D, Edwards, L A, Shoaie, S & Shawcross, D L 2022, ' Rifaximin-α reduces gut-derived inflammation and mucin degradation in cirrhosis and encephalopathy : RIFSYS randomised controlled trial ', Journal of Hepatology, vol. 76, no. 2, pp. 332-342 . https://doi.org/10.1016/j.jhep.2021.09.010
Background & Aims: Rifaximin-α is efficacious for the prevention of recurrent hepatic encephalopathy (HE), but its mechanism of action remains unclear. We postulated that rifaximin-α reduces gut microbiota-derived endotoxemia and systemic inflammat
Publikováno v:
Linchuang Gandanbing Zazhi, Vol 34, Iss 4, Pp 858-861 (2018)
Nuclear factor-kappa B (NF-κB) plays an important role in various physiological and pathological processes by regulating gene expression, such as cell survival, growth, proliferation, activation, and apoptosis. In particular, the NF-κB signaling pa
Publikováno v:
Biochimica et biophysica acta. Molecular basis of disease, 1864(3), 804-818. Elsevier
Biochimica et Biophysica Acta. Molecular Basis of Disease, 1864(3), 804. Elsevier
Biochimica et Biophysica Acta. Molecular Basis of Disease, 1864(3), 804. Elsevier
Quiescent hepatic stellate cells (HSCs), in response to liver injury, undergo characteristic morphological transformation into proliferative, contractile and ECM-producing myofibroblasts. In this study, we investigated the implication of canonical Wn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49c3c4bd0070f8e2a85578d91b05384
https://research.utwente.nl/en/publications/fdbc859d-eeb0-48f4-8123-96b424c00956
https://research.utwente.nl/en/publications/fdbc859d-eeb0-48f4-8123-96b424c00956
Autor:
Kimer, Nina, Pedersen, Julie S, Tavenier, Juliette, Christensen, Jeffrey E, Busk, Troels Malte, Hobolth, Lise, Krag, Aleksander, Al-Soud, Waleed Abu, Mortensen, Martin S, Sørensen, Søren J., Møller, Søren, Bendtsen, Flemming
Publikováno v:
Kimer, N, Pedersen, J S, Tavenier, J, Christensen, J E, Busk, T M, Hobolth, L, Krag, A, Al-Soud, W A, Mortensen, M S, Sørensen, S J, Møller, S, Bendtsen, F & And members of the CoRif study group 2018, ' Rifaximin has minor effects on bacterial composition, inflammation and bacterial translocation in cirrhosis : A randomized trial ', Journal of Gastroenterology and Hepatology, vol. 33, no. 1, pp. 307–314 . https://doi.org/10.1111/jgh.13852
Background and Aim: Decompensated cirrhosis is characterized by disturbed hemodynamics, immune dysfunction, and high risk of infections. Translocation of viable bacteria and bacterial products from the gut to the blood is considered a key driver in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3062::44f1b7886ab6ea0d005bb7282850ee86
https://findresearcher.sdu.dk:8443/ws/files/129514142/Rifaximin_has_minor_effects_on_bacterial_composition_inflammation_and_bacterial_translocation_in_cirrhosi.pdf
https://findresearcher.sdu.dk:8443/ws/files/129514142/Rifaximin_has_minor_effects_on_bacterial_composition_inflammation_and_bacterial_translocation_in_cirrhosi.pdf
Autor:
Garioud, Armand, Cadranel, Jean-François, Pauwels, Arnaud, Nousbaum, Jean-Baptiste, Thévenot, Thierry, Dao, Thong, Louvet, Alexandre, Sogni, Philippe, Talbodec, Nathalie, Antonini, Teresa, Bureau, Christophe, Thabut, Dominique, Elkrief, Laure, Jouannaud, Vincent, Macaigne, Gilles, Bernard-Chabert, Brigitte, Lison, Hortensia, Alric, Laurent, Carbonell, Nicolas, Labadie, Héléne, Amiot, Xavier, Abergel, Armand, Hanslik, Bertrand, Leroy, Vincent, De Lédinghen, Victor, Denis, Jacques
Publikováno v:
Journal of Clinical Gastroenterology
Journal of Clinical Gastroenterology, Lippincott, Williams & Wilkins, 2017, 51 (9), pp.831-838. ⟨10.1097/MCG.0000000000000735⟩
Journal of Clinical Gastroenterology, 2017, 51 (9), pp.831-838. ⟨10.1097/MCG.0000000000000735⟩
Journal of Clinical Gastroenterology, Lippincott, Williams & Wilkins, 2017, 51 (9), pp.831-838. ⟨10.1097/MCG.0000000000000735⟩
Journal of Clinical Gastroenterology, 2017, 51 (9), pp.831-838. ⟨10.1097/MCG.0000000000000735⟩
International audience; IntroductionThe use of human albumin for the management of cirrhosis has increased. Recommendations have been published for therapeutic paracentesis (TP), spontaneous bacterial peritonitis (SBP), and type 1 hepatorenal syndrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c8cd4d2b3d1719e7b7566f7e52aebdcd
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03149673
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03149673