Zobrazeno 1 - 10
of 236
pro vyhledávání: '"Liver Acinus"'
Publikováno v:
Biosensors, Vol 12, Iss 7, p 445 (2022)
Zonation along the liver acinus is considered a key feature of liver physiology. Here, we developed a liver acinus dynamic (LADY) chip that recapitulates a key functional structure of the liver acinus and hepatic zonation. Corresponding to the blood
Externí odkaz:
https://doaj.org/article/2650370c85c844cea63afda3e77f58b8
Autor:
Pedrycz Agnieszka, Boratyński Zbigniew, Siermontowski Piotr, Mendocha Jacek, Orłowski Marcin, Van Damme-Ostapowicz Katarzyna
Publikováno v:
Journal of Veterinary Research, Vol 57, Iss 1, Pp 125-133 (2014)
The aim of this study was to develop and examine a model of apoptosis and necrosis of hepatocytes induced by a damaging factor - adriamycin, correlating time after its administration with cell death type, and to investigate the localisation within th
Externí odkaz:
https://doaj.org/article/b05edd8661724b20b55879ad464a4747
Autor:
Alan Valdiviezo, Courtney Sakolish, Weihsueh A. Chiu, Lawrence Vernetti, Yu-Syuan Luo, Ivan Rusyn
Publikováno v:
Toxicology
Predicting human hepatic clearance remains a fundamental challenge in both pharmaceutical drug development and toxicological assessments of environmental chemicals, with concerns about both accuracy and precision of in vitro-derived estimates. Sugges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4397c2406c2a5d482d1839181bd4269
https://europepmc.org/articles/PMC8585690/
https://europepmc.org/articles/PMC8585690/
Autor:
Peter L. M. Jansen
Publikováno v:
The Liver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0aac39bfc48b14d8de33d3448851bb07
https://doi.org/10.1002/9781119436812.ch26
https://doi.org/10.1002/9781119436812.ch26
Akademický článek
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Autor:
Cheng Jun Jin, M Wammers, Judith Lang, Kai Stühler, Gereon Poschmann, Karl S. Lang, Dieter Häussinger, Martha Paluschinski, Boris Görg, Natalia Qvartskhava
Publikováno v:
Biological chemistryReferences. 402(9)
The structural-functional organization of ammonia and glutamine metabolism in the liver acinus involves highly specialized hepatocyte subpopulations like glutamine synthetase (GS) expressing perivenous hepatocytes (scavenger cells). However, this cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::521f3486268d902cbf1b30ea150044f4
https://pubmed.ncbi.nlm.nih.gov/34333885
https://pubmed.ncbi.nlm.nih.gov/34333885
Autor:
Masanori Tachikawa, Daisuke Saigusa, Kazunari Sasaki, Michitoshi Watanabe, Yasuo Uchida, Yuna Sumiyoshiya, Tetsuya Terasaki
Publikováno v:
Drug Metabolism and Disposition. 46:610-618
The purpose of the present study was to clarify the molecular basis of zonated drug distributions in mouse liver based on the protein expression levels of transporters and metabolizing enzymes in periportal (PP) and pericentral (PC) vein regions of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38cf10a05246ca9e5eb12ae4adb00d9b
https://doi.org/10.1124/dmd.117.079244
https://doi.org/10.1124/dmd.117.079244
Publikováno v:
Environmental Science and Pollution Research. 25:16427-16433
Animal studies show that exposure to the environmental pollutant 3,3’,4,4’,5-pentachlorobiphenyl (PCB126) causes alterations in hepatic metals as measured in acid-digested volume adjusted tissue. These studies lack the detail of the spatial distr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f2edf620e1a26615b305febac3ab0f
https://doi.org/10.1007/s11356-017-0202-0
https://doi.org/10.1007/s11356-017-0202-0
Autor:
Thomas Kietzmann
Publikováno v:
Redox Biology, Vol 11, Iss, Pp 622-630 (2017)
Redox Biology
Redox Biology
The liver has a multitude of functions which are necessary to maintain whole body homeostasis. This requires that various metabolic pathways can run in parallel in the most efficient manner and that futile cycles are kept to a minimum. To a large ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1cacb96e6030051afca90b6a144db40
http://www.sciencedirect.com/science/article/pii/S2213231716304499
http://www.sciencedirect.com/science/article/pii/S2213231716304499
Autor:
Mark T. Miedel, Andrew M. Stern, D. Lansing Taylor, Dillon C. Gavlock, Albert Gough, Shanhang Jia
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Reciprocal coevolution of tumors and their microenvironments underlies disease progression, yet intrinsic limitations of patient-derived xenografts and simpler cell-based models present challenges towards a deeper understanding of these intercellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53ae4b73d61f15d8dac17cc930a5430
http://europepmc.org/articles/PMC6554298
http://europepmc.org/articles/PMC6554298