Výsledky vyhledávání - "Liver/metabolism/pathology"

Metabolic syndrome and nonalcoholic fatty liver disease: Is insulin resistance the link?

Autor: François R Jornayvaz, Mohamed Asrih

Publikováno v: Molecular and Cellular Endocrinology, Vol. 418, No Pt 1 (2015) pp. 55-65

Metabolic syndrome (MetS) is a disease composed of different risk factors such as obesity, type 2 diabetes or dyslipidemia. The prevalence of this syndrome is increasing worldwide in parallel with the rise in obesity. Nonalcoholic fatty liver disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d5670e5ed9a734f44c8865a58e1cac
https://doi.org/10.1016/j.mce.2015.02.018

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Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets

Autor: Kévin Guilloux, Andrea Sanchez-Pareja, Manlio Vinciguerra, Lucie Bourgoin, David M. Suter, Stéphanie Pascarella, Francesco Negro, Sophie Clément, Marion Peyrou, Laura Rubbia-Brandt, Michelangelo Foti, Pierluigi Ramadori

Publikováno v: Hepatology (Baltimore Md.)
Hepatology, Vol. 54, No 1 (2011) pp. 38-49

Hepatitis C virus (HCV) perturbs the host's lipid metabolism and often results in hepatic steatosis. In nonalcoholic fatty liver disease, the intrahepatic down-regulation of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a critical

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Lactobacillus caseistrain Shirota protects against nonalcoholic steatohepatitis development in a rodent model

Autor: Okubo, H., Sakoda, H., Kushiyama, A., Fujishiro, M., Nakatsu, Y., Fukushima, Toshiaki, Matsunaga, Y., Kamata, H., Asahara, T., Yoshida, Y., Chonan, O., Iwashita, M., Nishimura, F., Asano, T.

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 305:G911-G918

Gut microbiota alterations are associated with various disorders. In this study, gut microbiota changes were investigated in a methionine-choline-deficient (MCD) diet-induced nonalcoholic steatohepatitis (NASH) rodent model, and the effects of admini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c9e88bb03ffc15f2046cf19c1f3271
https://doi.org/10.1152/ajpgi.00225.2013

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The liver and the kidney: two critical organs influencing the atherothrombotic risk in metabolic syndrome

Autor: Federico Carbone, Fabrizio Montecucco, François Mach, Francesca Viazzi, Roberto Pontremoli

Publikováno v: Thrombosis and Haemostasis; Vol 110
Thrombosis and Haemostasis, Vol. 110, No 5 (2013) pp. 940-958
Thrombosis and Haemostasis
Thrombosis and haemostasis

SummaryThe increased atherothrombotic risk in patients with metabolic syndrome (MetS) has been classically explained by the multiplicative effect of systemic concomitant pro-atherosclerotic factors. In particular, centripetal obesity, dyslipidaemia,

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Autologous bone marrow-derived cell transplantation in decompensated alcoholic liver disease: what is the impact on liver histology and gene expression patterns?

Autor: Nathalie Lin-Marq, Laurent Spahr, Nicolas Goossens, Laura Rubbia-Brandt, Sophie Clément, Nicolas Lanthier

Publikováno v: Stem Cell Research & Therapy
Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-10 (2017)
Stem Cell Research & Therapy, Vol. 8, No 1 (2017) P. 88
Stem Cell Research & Therapy, Vol. 8, no. 1, p. 88 [1-10] (2017)

Background Liver stem cell therapy (SCT) has been suggested as a promising means to improve liver regeneration in advanced liver disease. However, data from trials are heterogeneous, with no systematic histological evaluation. The aim of this study i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e18b6cfa6d41171d3cd99da0eff4db
https://pubmed.ncbi.nlm.nih.gov/28420441

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Gene Expression Profiling Provides Insights into Pathways of Oxaliplatin-Related Sinusoidal Obstruction Syndrome in Humans

Autor: Benoit Terris, Laura Rubbia-Brandt, Gilles Mentha, Sébastien Tauzin, Céline Delucinge-Vivier, Bertrand Dousset, Patrick Descombes, Catherine Brezault, Pietro Majno

Publikováno v: Molecular Cancer Therapeutics, Vol. 10, No 4 (2011) pp. 687-96

Sinusoidal obstruction syndrome (SOS; formerly veno-occlusive disease) is a well-established complication of hematopoietic stem cell transplantation, pyrrolizidine alkaloid intoxication, and widely used chemotherapeutic agents such as oxaliplatin. It

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee7d8c08a3145f46d1e1716aca70170
https://doi.org/10.1158/1535-7163.mct-10-1072

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Regulation of steatohepatitis and PPARgamma signaling by distinct AP-1 dimers

Autor: Hasenfuss, Sebastian C., Bakiri, Latifa, Thomsen, Martin K., Williams, Evan, Auwerx, Johan, Wagner, Erwin F.

Nonalcoholic fatty liver disease (NAFLD) affects up to 30% of the adult population in Western societies, yet the underlying molecular pathways remain poorly understood. Here, we identify the dimeric Activator Protein 1 as a regulator of NAFLD. Fos-re

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http://orbilu.uni.lu/handle/10993/43162

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Adipocyte dysfunction in a mouse model of polycystic ovary syndrome (PCOS): evidence of adipocyte hypertrophy and tissue-specific inflammation

Autor: Jennifer W. Hill, Jens C. Brüning, Jeffrey Iler, Streamson C. Chua, Joseph S. Marino, Abigail R. Dowling, Roberto Coppari

Publikováno v: PLoS ONE
PLoS ONE, Vol 7, Iss 10, p e48643 (2012)
PLOS ONE, Vol. 7, No 10 (2012) P. e48643

Clinical research shows an association between polycystic ovary syndrome (PCOS) and chronic inflammation, a pathological state thought to contribute to insulin resistance. The underlying pathways, however, have not been defined. The purpose of this s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c1002832319a9e245d6cd0578732e8
https://pubmed.ncbi.nlm.nih.gov/23119079

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Further Evidence for Amyloid Deposition in Clinical Pancreatic Islet Grafts

Autor: Franco Folli, Per Westermark, Tatsuya Kin, Arne Andersson, A. M. James Shapiro, Alberto M. Davalli, Gunnar Tufveson, Gunilla T. Westermark, Antonio Secchi, Olle Korsgren, Christian Toso

Publikováno v: Transplantation, Vol. 93, No 2 (2012) pp. 219-23

Background. The reasons for the long-term complete or partial loss of islet graft function are unknown, but there areobviously other reasons than just pure allogeneic graft rejection. Earlier studies have shown that deposition of isletamyloid polypep

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A mouse model of β-thalassemia shows a liver-specific down-regulation of Abcc6 expression

Autor: Vanessa Douet, Matthew B. Heller, Christopher M. VanWart, Olivier Le Saux, Ludovic Martin

Publikováno v: The American journal of pathology
The American journal of pathology, 2011, 178 (2), pp.774-83. ⟨10.1016/j.ajpath.2010.10.004⟩

International audience; beta-Thalassemia and pseudoxanthoma elasticum (PXE) are distinct genetic disorders. Yet, a dystrophic mineralization phenotype similar to PXE has frequently been associated with beta-thalassemia or sickle cell anemia patients

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https://pubmed.ncbi.nlm.nih.gov/21281810

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