Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver

Autor: Jean-Michel Fustin, Hao Wen Chen, Masao Doi, Hsu Wen Chao, Pei Yun Young, Hsien San Hou, Shu Hui Lin, Huatao Chen, Pei Chih King, Yen Lurk Lee, Yen Sung Huang, Hui Huang Lai, Heng Lin

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Lin, H, Huang, Y-S, Fustin, J-M, Doi, M, Chen, H, Lai, H-H, Lin, S-H, King, P-C, Hou, H-S, Chen, H-W, Young, P-Y & Chao, H-W 2021, ' Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver ', Nature Communications, vol. 12, no. 1, pp. 645 . https://doi.org/10.1038/s41467-020-20572-8
Lin, H, Huang, Y-S, Fustin, J-M, Doi, M, Chen, H, Lai, H-H, Lin, S-H, Lee, Y-L, King, P-C, Hou, H-S, Chen, H-W, Young, P-Y & Chao, H-W 2021, ' Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver ', Nature Communications, vol. 12, no. 1, 645 . https://doi.org/10.1038/s41467-020-20572-8

Hepatocellular carcinoma (HCC) is the most predominant primary malignancy in the liver. Genotoxic and genetic models have revealed that HCC cells are derived from hepatocytes, but where the critical region for tumor foci emergence is and how this tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4a90250a26229102d4437b41f7865a
https://doaj.org/article/2a6b0a8610cd4b32b27ac9dde0bc48ce

Rifampicin, not vitamin E, suppresses parenteral nutrition-associated liver disease development through the pregnane X receptor pathway in piglets

Autor: Gregory Guthrie, Charlotte Lauridsen, Douglas G. Burrin, Shaji Chacko, Barbara Stoll, Jogchum Plat

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology, 318(1), G41-G52. American Physiological Society
Guthrie, G, Stoll, B, Chacko, S, Lauridsen, C, Plat, J & Burrin, D G 2020, ' Rifampicin, not vitamin E, suppresses parenteral nutrition-associated liver disease development through the pregnane X receptor pathway in piglets ', American Journal of Physiology: Gastrointestinal and Liver Physiology, vol. 318, no. 1, pp. G41-G52 . https://doi.org/10.1152/ajpgi.00193.2019
Am J Physiol Gastrointest Liver Physiol

Infants receiving long-term parenteral nutrition (PN) develop PN-associated liver disease (PNALD). We previously (Ng K et al. JPEN J Parenter Enteral Nutr 40: 656–671, 2016. doi: 10.1177/0148607114567900 .) showed that PN containing soy-based lipid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d93c23b8e62b533153371662603600
https://doi.org/10.1152/ajpgi.00193.2019

The application of omics-based human liver platforms for investigating the mechanism of drug-induced hepatotoxicity in vitro

Autor: Theo M. de Kok, Gökhan Ertaylan, Charlie D Pieterman, Jian Jiang, Ralf Peeters

Publikováno v: Archives of Toxicology. 93:3067-3098

Drug-induced liver injury (DILI) complicates safety assessment for new drugs and poses major threats to both patient health and drug development in the pharmaceutical industry. A number of human liver cell-based in vitro models combined with toxicoge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f2bbf8ee49c1491affb3577c1e40f5
https://doi.org/10.1007/s00204-019-02585-5

Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases

Autor: Helena Zander Wodschow, Nicole Jacqueline Jensen, Malin Nilsson, Jørgen Rungby

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 8767, p 8767 (2020)
Jensen, N J, Wodschow, H Z, Nilsson, M & Rungby, J 2020, ' Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases ', International Journal of Molecular Sciences, vol. 21, no. 22, 8767 . https://doi.org/10.3390/ijms21228767
International Journal of Molecular Sciences

Under normal physiological conditions the brain primarily utilizes glucose for ATP generation. However, in situations where glucose is sparse, e.g., during prolonged fasting, ketone bodies become an important energy source for the brain. The brain’

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5c473855e864b6d72fdac48583ef9c
https://www.mdpi.com/1422-0067/21/22/8767

Suspensão oral de rutina interfere na hiperplasia hepática em ratos

Autor: Pedro Paulo BARROS, André Bernardo de Camargo EISINGER, Gisele Mara Silva GONÇALVES, Gustavo Henrique da SILVA

Publikováno v: Arquivos de Gastroenterologia v.57 n.3 2020
Arquivos de gastroenterologia
Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia
instacron:IBEPEGE
Arquivos de Gastroenterologia, Vol 57, Iss 3, Pp 296-299 (2020)
Arquivos de Gastroenterologia, Volume: 57, Issue: 3, Pages: 296-299, Published: 02 OCT 2020

BACKGROUND: Rutin is a flavonol glycoside that can be found in a wide variety of vegetables and has activity, anti-cancer, anti-inflammatory and anti-diabetic properties. OBJECTIVE: This study investigated the effect of rutin oral administration on W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c4e74862fde566194dd28b9149555b
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032020000300296