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pro vyhledávání: '"Liver/*immunology/pathology"'
High Pathogenic Potential of Low-Affinity Autoantibodies in Experimental Autoimmune Hemolytic Anemia
Autor:
Jeffrey V. Ravetch, Raphael Clynes, Shozo Izui, Yves Chicheportiche, Liliane Fossati-Jimack, Luc Reininger, Tasuku Honjo
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine, Vol. 190, No 11 (1999) pp. 1689-1696
Journal of Experimental Medicine, Vol. 190, No 11 (1999) pp. 1689-1696
To assess the potency of low-affinity anti–red blood cell (RBC) autoantibodies in the induction of anemia, we generated an immunoglobulin (Ig)G2a class-switch variant of a 4C8 IgM anti–mouse RBC autoantibody, and compared its pathogenic potential