Cystic Fibrosis Airway Mucus Hyperconcentration Produces a Vicious Cycle of Mucin, Pathogen, and Inflammatory Interactions that Promotes Disease Persistence.

Autor: Batson BD; Marsico Lung Institute/Cystic Fibrosis Research Center.; Department of Pathology and Laboratory Medicine., Zorn BT; Marsico Lung Institute/Cystic Fibrosis Research Center.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Radicioni G; Marsico Lung Institute/Cystic Fibrosis Research Center.; Department of Pathology and Laboratory Medicine., Livengood SS; Marsico Lung Institute/Cystic Fibrosis Research Center.; Department of Pathology and Laboratory Medicine., Kumagai T; Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia., Dang H; Marsico Lung Institute/Cystic Fibrosis Research Center., Ceppe A; Marsico Lung Institute/Cystic Fibrosis Research Center., Clapp PW; Marsico Lung Institute/Cystic Fibrosis Research Center., Tunney M; Queen's University, Belfast, Northern Ireland, United Kingdom; and., Elborn JS; Queen's University, Belfast, Northern Ireland, United Kingdom; and., McElvaney NG; Irish Centre for Genetic Lung Disease, Royal College of Surgeons in Ireland Education and Research Centre, Beaumont Hospital, Dublin, Ireland., Muhlebach MS; Marsico Lung Institute/Cystic Fibrosis Research Center., Boucher RC; Marsico Lung Institute/Cystic Fibrosis Research Center., Tiemeyer M; Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia., Wolfgang MC; Marsico Lung Institute/Cystic Fibrosis Research Center.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Kesimer M; Marsico Lung Institute/Cystic Fibrosis Research Center.; Department of Pathology and Laboratory Medicine.

Publikováno v: American journal of respiratory cell and molecular biology [Am J Respir Cell Mol Biol] 2022 Aug; Vol. 67 (2), pp. 253-265.