Gastrointestinal germinal center B cell depletion and reduction in IgA ⁺ plasma cells in HIV-1 infection.

Autor: Cossarini F; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Shang J; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Krek A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Al-Taie Z; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hou R; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Canales-Herrerias P; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tokuyama M; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tankelevich M; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tillowitz A; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Jha D; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Livanos AE; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Leyre L; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Uzzan M; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Gastroenterology Department, Hôpital Henri Mondor, APHP, Créteil, France., Martinez-Delgado G; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Taylor MD; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Sharma K; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bourgonje AR; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Cruz M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ioannou G; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Dawson T; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., D'Souza D; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kim-Schulze S; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Akm A; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Aberg JA; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Chen BK; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kwon DS; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA., Gnjatic S; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Polydorides AD; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Cerutti A; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Translational Clinical Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.; Catalan Institute for Research and Advanced Studies (ICREA), Barcelona, Spain., Argmann C; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Vujkovic-Cvijin I; F. Widjaja IBD Institute, Division of Gastroenterology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Suarez-Fariñas M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Petralia F; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Faith JJ; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mehandru S; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Publikováno v: Science immunology [Sci Immunol] 2024 Oct 25; Vol. 9 (100), pp. eado0090. Date of Electronic Publication: 2024 Oct 25.

Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis.

Autor: Canales-Herrerias P; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Uzzan M; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Paris Est Créteil University UPEC, Assistance Publique-Hôpitaux de Paris (AP-HP), Henri Mondor Hospital, Gastroenterology Department, Fédération Hospitalo-Universitaire TRUE (InnovaTive theRapy for immUne disordErs), Créteil F-94010, France., Seki A; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Czepielewski RS; Department of Pathology, Washington University School of Medicine, St. Louis, MO, USA., Verstockt B; Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium.; Translational Research in Gastrointestinal Disorders, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium., Livanos AE; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Raso F; Department of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Dunn A; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Dai D; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wang A; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Al-Taie Z; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Martin J; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nantes Université, CHU Nantes, Inserm, Centre de Recherche Translationelle en Transplantation et Immunologie, UMR 1064, Nantes, France.; CHU Nantes, Nantes Université, Laboratoire d'Immunologie, CIMNA, Nantes, France., Laurent T; Nantes Université, CHU Nantes, Inserm, Centre de Recherche Translationelle en Transplantation et Immunologie, UMR 1064, Nantes, France.; CHU Nantes, Nantes Université, Laboratoire d'Immunologie, CIMNA, Nantes, France., Ko HM; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tokuyama M; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tankelevich M; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Meringer H; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Cossarini F; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Jha D; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Krek A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Paulsen JD; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Taylor MD; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Nakadar MZ; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wong J; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Erlich EC; Department of Pathology, Washington University School of Medicine, St. Louis, MO, USA., Mintz RL; Department of Pathology, Washington University School of Medicine, St. Louis, MO, USA., Onufer EJ; Division of Pediatric Surgery, Department of Surgery, St. Louis Children's Hospital, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Helmink BA; Department of Surgery, Section of Surgical Oncology, Washington University School of Medicine, St. Louis, MO, USA., Sharma K; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Rosenstein A; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ganjian D; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Chung G; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Dawson T; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Juarez J; Takeda Pharmaceuticals, Cambridge, MA, USA., Yajnik V; Takeda Pharmaceuticals, Cambridge, MA, USA., Cerutti A; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Translational Clinical Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.; Catalan Institute for Research and Advanced Studies (ICREA), Barcelona, Spain., Faith JJ; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Suarez-Farinas M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Argmann C; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Petralia F; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Randolph GJ; Department of Pathology, Washington University School of Medicine, St. Louis, MO, USA., Polydorides AD; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Reboldi A; Department of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Colombel JF; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mehandru S; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Publikováno v: Science immunology [Sci Immunol] 2024 Apr 19; Vol. 9 (94), pp. eadg7549. Date of Electronic Publication: 2024 Apr 19.

Myeloid cell influx into the colonic epithelium is associated with disease severity and non-response to anti-Tumor Necrosis Factor Therapy in patients with Ulcerative Colitis.

Autor: Jha D; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Al-Taie Z; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, New York City, NY, USA., Krek A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, NY, USA., Eshghi ST; Biomarker Discovery, OMNI, Genentech Inc. South SanFrancisco, CA, USA.; OMNI Biomarker Development, Genentech Inc. South SanFrancisco, CA, USA., Fantou A; Université de Nantes, Inserm, CHU Nantes, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, F-44000 Nantes, France., Laurent T; Université de Nantes, Inserm, CHU Nantes, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, F-44000 Nantes, France., Tankelevich M; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Cao X; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, NY, USA., Meringer H; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Livanos AE; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tokuyama M; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Cossarini F; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bourreille A; Université de Nantes, Inserm, CHU Nantes, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, F-44000 Nantes, France., Josien R; Université de Nantes, Inserm, CHU Nantes, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, F-44000 Nantes, France., Hou R; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, New York City, NY, USA., Canales-Herrerias P; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ungaro RC; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kayal M; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Marion J; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Polydorides AD; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ko HM; Department of Pathology and Cell Biology, Columbia University Medical Center-New York Presbyterian Hospital, New York, New York., D'souza D; Human Immune Monitoring Core, Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Merand R; Human Immune Monitoring Core, Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kim-Schulze S; Human Immune Monitoring Core, Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hackney JA; Biomarker Discovery, OMNI, Genentech Inc. South SanFrancisco, CA, USA.; OMNI Biomarker Development, Genentech Inc. South SanFrancisco, CA, USA., Nguyen A; Biomarker Discovery, OMNI, Genentech Inc. South SanFrancisco, CA, USA.; OMNI Biomarker Development, Genentech Inc. South SanFrancisco, CA, USA., McBride JM; Biomarker Discovery, OMNI, Genentech Inc. South SanFrancisco, CA, USA.; OMNI Biomarker Development, Genentech Inc. South SanFrancisco, CA, USA., Yuan GC; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, NY, USA., Colombel JF; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Martin JC; Université de Nantes, Inserm, CHU Nantes, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, F-44000 Nantes, France., Argmann C; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, New York City, NY, USA., Suárez-Fariñas M; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, New York City, NY, USA., Petralia F; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, NY, USA., Mehandru S; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jun 05. Date of Electronic Publication: 2023 Jun 05.

Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity.

Autor: Uzzan M; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Paris Est Créteil University UPEC, Assistance Publique-Hôpitaux de Paris (AP-HP), Henri Mondor Hospital, Fédération Hospitalo-Universitaire, InnovaTive theRapy for immUne disordErs (TRUE), Gastroenterology Department, Créteil, France., Martin JC; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Université de Nantes, INSERM, CHU Nantes, Centre de Recherche en Transplantation et Immunologie, Nantes, France.; CHU Nantes, Laboratoire d'Immunologie, Center for Immuno Monitoring Nantes-Atlantique (CIMNA), Nantes, France., Mesin L; Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA., Livanos AE; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Castro-Dopico T; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK., Huang R; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Petralia F; Department of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Magri G; Translational Clinical Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain., Kumar S; Washington University School of Medicine, St. Louis, MO, USA., Zhao Q; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Rosenstein AK; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tokuyama M; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Sharma K; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ungaro R; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kosoy R; Department of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, New York, NY, USA., Jha D; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Fischer J; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Singh H; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Keir ME; Biomarker Discovery, OMNI, Genentech Inc., South San Francisco, CA, USA., Ramamoorthi N; Biomarker Discovery, OMNI, Genentech Inc., South San Francisco, CA, USA., O'Gorman WE; OMNI Biomarker Development, Genentech Inc., South San Francisco, CA, USA., Cohen BL; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Rahman A; Department of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Core, Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Immunai, New York NY, USA., Cossarini F; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Seki A; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Leyre L; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Vaquero ST; Translational Clinical Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain., Gurunathan S; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Grasset EK; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine Division of Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Losic B; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, New York, NY, USA., Dubinsky M; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Greenstein AJ; Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Gottlieb Z; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Legnani P; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., George J; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Irizar H; Department of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Stojmirovic A; Janssen R&D, Spring House, Philadelphia, PA, USA., Brodmerkel C; Janssen R&D, Spring House, Philadelphia, PA, USA., Kasarkis A; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, New York, NY, USA.; Sema4, Stamford, CT, USA., Sands BE; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Furtado G; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lira SA; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tuong ZK; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.; Cellular Genetics, Wellcome Sanger Institute, Hinxton, UK., Ko HM; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Cerutti A; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Translational Clinical Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.; Catalan Institute for Research and Advanced Studies (ICREA), Barcelona, Spain., Elson CO; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Clatworthy MR; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.; Cellular Genetics, Wellcome Sanger Institute, Hinxton, UK., Merad M; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Suárez-Fariñas M; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, New York, NY, USA., Argmann C; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, New York, NY, USA., Hackney JA; Bioinformatics and Computational Biology, Genentech Inc., South San Francisco, CA, USA., Victora GD; Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA., Randolph GJ; Washington University School of Medicine, St. Louis, MO, USA., Kenigsberg E; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Colombel JF; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mehandru S; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. saurabh.mehandru@mssm.edu.; Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. saurabh.mehandru@mssm.edu.

Publikováno v: Nature medicine [Nat Med] 2022 Apr; Vol. 28 (4), pp. 766-779. Date of Electronic Publication: 2022 Feb 21.

Intestinal Host Response to SARS-CoV-2 Infection and COVID-19 Outcomes in Patients With Gastrointestinal Symptoms.

Autor: Livanos AE; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York; The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York., Jha D; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York; The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York., Cossarini F; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Division of Infectious Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York., Gonzalez-Reiche AS; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York., Tokuyama M; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York; The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York., Aydillo T; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York., Parigi TL; Department of Biomedical Sciences, Humanitas University, Milan, Italy., Ladinsky MS; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California., Ramos I; Department of Neurology and Center for Advanced Research on Diagnostic Assays, Icahn School of Medicine at Mount Sinai, New York, New York., Dunleavy K; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York., Lee B; Human Immune Monitoring Center (HIMC) Icahn School of Medicine at Mount Sinai New York, New York, New York., Dixon RE; The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York., Chen ST; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York., Martinez-Delgado G; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York; The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York., Nagula S; The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York., Bruce EA; Division of Immunobiology, Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, Vermont., Ko HM; The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Pathology, Molecular and Cell Based Medicine Icahn School of Medicine at Mount Sinai, New York, New York., Glicksberg BS; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; The Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, New York., Nadkarni G; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; The Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, New York; The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; The Mount Sinai Clinical Intelligence Center, Icahn School of Medicine at Mount Sinai, New York, New York., Pujadas E; Department of Pathology, Molecular and Cell Based Medicine Icahn School of Medicine at Mount Sinai, New York, New York., Reidy J; Department of Pathology, Molecular and Cell Based Medicine Icahn School of Medicine at Mount Sinai, New York, New York., Naymagon S; The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York., Grinspan A; The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York., Ahmad J; The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York., Tankelevich M; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York; The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York., Bram Y; Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, New York., Gordon R; Department of Pathology, Molecular and Cell Based Medicine Icahn School of Medicine at Mount Sinai, New York, New York., Sharma K; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York; The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York., Houldsworth J; Department of Pathology, Molecular and Cell Based Medicine Icahn School of Medicine at Mount Sinai, New York, New York., Britton GJ; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York., Chen-Liaw A; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York., Spindler MP; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York., Plitt T; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York., Wang P; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York., Cerutti A; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Catalan Institute for Research and Advanced Studies, Barcelona, Spain; Program for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain., Faith JJ; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York., Colombel JF; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York; The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York., Kenigsberg E; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York., Argmann C; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York., Merad M; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; Human Immune Monitoring Center (HIMC) Icahn School of Medicine at Mount Sinai New York, New York, New York; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York., Gnjatic S; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; Human Immune Monitoring Center (HIMC) Icahn School of Medicine at Mount Sinai New York, New York, New York; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Pathology, Molecular and Cell Based Medicine Icahn School of Medicine at Mount Sinai, New York, New York., Harpaz N; Department of Pathology, Molecular and Cell Based Medicine Icahn School of Medicine at Mount Sinai, New York, New York., Danese S; Department of Biomedical Sciences, Humanitas University, Milan, Italy., Cordon-Cardo C; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Pathology, Molecular and Cell Based Medicine Icahn School of Medicine at Mount Sinai, New York, New York., Rahman A; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Human Immune Monitoring Center (HIMC) Icahn School of Medicine at Mount Sinai New York, New York, New York; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York., Schwartz RE; Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, New York., Kumta NA; The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York., Aghemo A; Department of Biomedical Sciences, Humanitas University, Milan, Italy., Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California., Petralia F; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: francesca.Petralia@mssm.edu., van Bakel H; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: harm.vanbakel@mssm.edu., Garcia-Sastre A; Division of Infectious Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: adolfo.Garcia-Sastre@mssm.edu., Mehandru S; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York; The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: saurabh.mehandru@mssm.edu.

Publikováno v: Gastroenterology [Gastroenterology] 2021 Jun; Vol. 160 (7), pp. 2435-2450.e34. Date of Electronic Publication: 2021 Mar 04.