Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Liv B. Gansmo"'
Autor:
Nigar Sofiyeva, Camilla Krakstad, Mari K. Halle, Tracy A. O'Mara, Pål Romundstad, Kristian Hveem, Lars Vatten, Per E. Lønning, Liv B. Gansmo, Stian Knappskog
Publikováno v:
Cancer Medicine, Vol 12, Iss 6, Pp 6659-6667 (2023)
Abstract Background A common 30 kb deletion affecting the APOBEC3A and APOBEC3B genes has been linked to increased APOBEC activity and APOBEC‐related mutational signatures in human cancers. The role of this deletion as a cancer risk factor remains
Externí odkaz:
https://doaj.org/article/4ceaeac0dc614338b1f48747cdc9b398
Autor:
Liv B. Gansmo, Nigar Sofiyeva, Merete Bjørnslett, Pål Romundstad, Kristian Hveem, Lars Vatten, Anne Dørum, Per E. Lønning, Stian Knappskog
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract A germline 29.5-kb deletion variant removes the 3’ end of the APOBEC3A gene and a large part of APOBEC3B, creating a hybrid gene that has been linked to increased APOBEC3 activity and DNA damage in human cancers. We genotyped the APOBEC3A/
Externí odkaz:
https://doaj.org/article/12a41c4868b348eebff763953c5fbf09
Autor:
Johanna Huun, Liv B. Gansmo, Bård Mannsåker, Gjertrud T. Iversen, Jan Sommerfelt-Pettersen, Jan Inge Øvrebø, Per E. Lønning, Stian Knappskog
Publikováno v:
Translational Oncology, Vol 10, Iss 5, Pp 806-817 (2017)
BACKGROUND: MDM2 is a negative regulator of p53 and is upregulated in numerous human cancers. While different MDM2 splice variants have been observed in both normal tissues and malignant cells, their functions are poorly understood. METHODS: We evalu
Externí odkaz:
https://doaj.org/article/984fb2741bd640468078af8a1510e84f
Autor:
Johanna Huun, Liv B. Gansmo, Bård Mannsåker, Gjertrud Titlestad Iversen, Jan Inge Øvrebø, Per E. Lønning, Stian Knappskog
Publikováno v:
BMC Cell Biology, Vol 18, Iss 1, Pp 1-9 (2017)
Abstract Background The murine double minute 2 (MDM2) is an oncogene and a negative regulator of the tumor suppressor protein p53. MDM2 is known to be amplified in numerous human cancers, and upregulation of MDM2 is considered to be an alternative me
Externí odkaz:
https://doaj.org/article/f268acc168ec49dc856cd974179968ac
Autor:
Nigar Sofiyeva, Camilla Krakstad, Mari K. Halle, Tracy A. O'Mara, Pål Romundstad, Kristian Hveem, Lars Vatten, Per E. Lønning, Liv B. Gansmo, Stian Knappskog
Publikováno v:
Cancer Medicine
Background A common 30 kb deletion affecting the APOBEC3A and APOBEC3B genes has been linked to increased APOBEC activity and APOBEC-related mutational signatures in human cancers. The role of this deletion as a cancer risk factor remains controversi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234b812e89b95dc5cdcfb4006d6a201b
https://doi.org/10.1002/cam4.5448
https://doi.org/10.1002/cam4.5448
Autor:
Kathleen M. McAndrews, Daniel J. McGrail, Liv B. Gansmo, Sara P.Y. Che, Deepavali Chakravarti, Valerie S. LeBleu, Raghu Kalluri
Fibroblasts are spindle-shaped mesenchymal cells and an abundantly studied cell type that are easy to culture. Their adaptive response in culture conditions allows for use in many different cell biological experiments, including their utility in gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9473f42ab25283a2d8b5f782b19b889f
https://doi.org/10.1101/2022.08.18.504466
https://doi.org/10.1101/2022.08.18.504466
Autor:
Benedicte A. Lie, Marthe T. Maehlen, Per Eystein Lønning, Stian Knappskog, Kristian Hveem, Liv B. Gansmo, Lars J. Vatten, Pål Richard Romundstad
Publikováno v:
Gene
Background In addition to being a tumour suppressor, TP53 is a suppressor of inflammation, and dysfunction of this gene has been related to autoimmune diseases. Patients with autoimmunity, such as rheumatoid arthritis (RA) have an increased risk of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2ccafd2186ae875d974f45a23cac9ed
https://hdl.handle.net/11250/2991469
https://hdl.handle.net/11250/2991469
Autor:
Michael Tachezy, Maximilian Bockhorn, Raghu Kalluri, Jena L. Tavormina, Paul Kurywchak, Sara P.Y. Che, Amanda R. Haltom, Liv B. Gansmo, Sujuan Yang, Valerie S. LeBleu, Sonia A. Melo, Florian Gebauer, Pedro Correa de Sampaio
Publikováno v:
Cancer Biology & Therapy. 18:158-165
Pancreatic cancer presents with a dismal mortality rate and is in urgent need of methods for early detection with potential for timely intervention. All living cells, including cancer cells, generate exosomes. We previously discovered double stranded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b7a8381d17ed33407f9e4f5aeec537
https://doi.org/10.1080/15384047.2017.1281499
https://doi.org/10.1080/15384047.2017.1281499
Autor:
Stian, Knappskog, Beryl, Leirvaag, Liv B, Gansmo, Pål, Romundstad, Kristian, Hveem, Lars, Vatten, Per E, Lønning
Publikováno v:
Hereditary Cancer in Clinical Practice
Background While germline CHEK2 mutations have been linked to a moderately elevated cancer risk, to date, a limited number of such mutations have been identified. Recently, we reported a germline nonsense mutation (C283T; R95*), introducing an early
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3ac7dc3c406e206e83610fa8a01a2c0c
https://pubmed.ncbi.nlm.nih.gov/27708748
https://pubmed.ncbi.nlm.nih.gov/27708748
Autor:
Stian Knappskog, Liv B Gansmo, Pål Romundstad, Merete Bjørnslett, Jone Trovik, Jan Sommerfelt-Pettersen, Erik Løkkevik, Norwegian Breast Cancer Group trial NBCG VI, Rob A E M Tollenaar, Caroline Seynaeve, Peter Devilee, Helga B Salvesen, Anne Dørum, Kristian Hveem, Lars Vatten, Per E Lønning
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e36263 (2012)
The MDM2 proto-oncogene plays a key role in central cellular processes like growth control and apoptosis, and the gene locus is frequently amplified in sarcomas. Two polymorphisms located in the MDM2 promoter P2 have been shown to affect cancer risk.
Externí odkaz:
https://doaj.org/article/73927cc6763348dd8815069ae625c8b3