Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Liufu, Deng"'
Autor:
Yingzhi Chen, Ruike Li, Qiao Duan, Lingling Wu, Xinyi Li, Aoxiang Luo, Yongming Zhang, Na Zhao, Kai Cui, Wenwei Wu, Tize Liu, Jian‐Bo Wan, Liufu Deng, Guiying Li, Lijun Hou, Weihong Tan, Zeyu Xiao
Publikováno v:
Advanced Science, Vol 11, Iss 32, Pp n/a-n/a (2024)
Abstract The activation of cyclic GMP‐AMP (cGAMP) synthase (cGAS) and its adaptor, stimulator of interferon genes (STING), is known to reprogram the immunosuppressive tumor microenvironment for promoting antitumor immunity. To enhance the efficienc
Externí odkaz:
https://doaj.org/article/3a4fa06c0ca94787bb78c4697c2a55ef
Publikováno v:
Cancer Biology & Medicine, Vol 20, Iss 12, Pp 1035-1046 (2023)
Maintenance immunotherapy after concurrent chemoradiotherapy remains the standard therapeutic approach in patients with unresectable locally advanced non-small cell lung cancer (LA-NSCLC). The efficacy of pembrolizumab without chemotherapy in stage I
Externí odkaz:
https://doaj.org/article/5fe4afed98eb4d04b203a999fdfdcece
Autor:
Xinran Wang, Lu Lu, Xiaochuan Hong, Lingling Wu, Chao Yang, You Wang, Wenwen Li, Yuanqin Yang, Dongqing Cao, Wen Di, Liufu Deng
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113712- (2024)
Summary: Adoptive cell therapies are emerging forms of immunotherapy that reprogram T cells for enhanced antitumor responses. Although surface programmed cell death-ligand 1 (PD-L1)/programmed cell death protein 1 (PD-1) engagement inhibits antitumor
Externí odkaz:
https://doaj.org/article/c211f961db7e47afa0a8ede41e1bee65
Autor:
Lu Lu, Chao Yang, Xingyue Zhou, Lingling Wu, Xiaochuan Hong, Wenwen Li, Xinran Wang, Yuanqin Yang, Dongqing Cao, Ao Zhang, Wen Di, Liufu Deng
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113108- (2023)
Summary: Natural killer (NK) cells are cytotoxic innate lymphocytes that eradicate tumor cells. Inducing durable antitumor immune responses by NK cells represents a major priority of cancer immunotherapy. While cytosolic DNA sensing plays an essentia
Externí odkaz:
https://doaj.org/article/44425f5759c74c5aa177f82e54668fa4
Mitotic SENP3 activation couples with cGAS signaling in tumor cells to stimulate anti-tumor immunity
Autor:
Gaolei Hu, Yalan Chen, Xinyu Yang, Yang Wang, Jianli He, Tianshi Wang, Qiuju Fan, Liufu Deng, Jun Tu, Hongsheng Tan, Jinke Cheng
Publikováno v:
Cell Death and Disease, Vol 13, Iss 7, Pp 1-11 (2022)
Abstract Our previous studies show that the mitotic phosphorylation of SUMO-specific protease 3 (SENP3) can inhibit its de-SUMOylation activity in G2/M phase of the cell cycle. Inhibition of SENP3 plays a critical role in the correct separation of si
Externí odkaz:
https://doaj.org/article/61f88f0ecc4248ab8452b30e6b17e0b0
Autor:
Jianli He, Xun Shangguan, Wei Zhou, Ying Cao, Quan Zheng, Jun Tu, Gaolei Hu, Zi Liang, Cen Jiang, Liufu Deng, Shengdian Wang, Wen Yang, Yong Zuo, Jiao Ma, Rong Cai, Yalan Chen, Qiuju Fan, Baijun Dong, Wei Xue, Hongsheng Tan, Yitao Qi, Jianmin Gu, Bing Su, Y. Eugene Chin, Guoqiang Chen, Qi Wang, Tianshi Wang, Jinke Cheng
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Memory T cells are particularly reliant on fatty acid oxidation as a source of energy. Here the authors show this reliance is controlled by AMPK sensing of glucose deprivation that triggers SENP1-Sirt3 signalling, driving fatty acid oxidation and mem
Externí odkaz:
https://doaj.org/article/102b38001d4a4513871efcad72767745
Autor:
Hua Liang, Liufu Deng, Yuzhu Hou, Xiangjiao Meng, Xiaona Huang, Enyu Rao, Wenxin Zheng, Helena Mauceri, Matthias Mack, Meng Xu, Yang-Xin Fu, Ralph R. Weichselbaum
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Tumors often develop resistance to radiotherapy. Here the authors show that irradiation leads to a CCR2-dependent infiltration by myeloid derived suppressor cells that promote radio-resistance through inhibition of adaptive immune responses and that
Externí odkaz:
https://doaj.org/article/41119c097be14bc98b46b9c80e885446
Autor:
Chunyong Ding, Mengyan Du, Zhi Xiong, Xue Wang, Hongji Li, Ende He, Han Li, Yijing Dang, Qing Lu, Shicong Li, Ruoxuan Xiao, Zhiai Xu, Lili Jing, Liufu Deng, Xiyuan Wang, Meiyu Geng, Zuoquan Xie, Ao Zhang
Publikováno v:
Chemical Science.
A photo-caged STING agonist featuring a tumor-targeting carbonic anhydrase warhead was designed and synthesized for photo-controllable activation of STING signaling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdcbc15d39a638c73b2c1a85fff8b422
https://doi.org/10.1039/d3sc01896b
https://doi.org/10.1039/d3sc01896b
Autor:
Bing Su, Yalan Chen, Zi Liang, Quan Zheng, Rong Cai, Jianmin Gu, Qi Wang, Wen Yang, Qiuju Fan, Gaolei Hu, Y. Eugene Chin, Jiao Ma, Ying Cao, Liufu Deng, Yitao Qi, Guo-Qiang Chen, Tianshi Wang, Wei Zhou, Yong Zuo, Jun Tu, Wei Xue, Xun Shangguan, Cen Jiang, Shengdian Wang, Jinke Cheng, Hongsheng Tan, Baijun Dong, Jianli He
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Metabolic programming and mitochondrial dynamics along with T cell differentiation affect T cell fate and memory development; however, how to control metabolic reprogramming and mitochondrial dynamics in T cell memory development is unclear. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef708a9f8986ab939506c26806594cc6
https://doaj.org/article/102b38001d4a4513871efcad72767745
https://doaj.org/article/102b38001d4a4513871efcad72767745
Autor:
Mina Yang, Haojie Jiang, Chen Ding, Lin Zhang, Nan Ding, Guoming Li, Fei Zhang, Jing Wang, Liufu Deng, Junling Liu, Yanyan Xu
Publikováno v:
Immunity. 56:1013-1026.e6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5854864664b28273875c073c0931282
https://doi.org/10.1016/j.immuni.2023.02.015
https://doi.org/10.1016/j.immuni.2023.02.015