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Increased expression of schizophrenia-associated gene C4 leads to hypoconnectivity of prefrontal cortex and reduced social interaction.

Autor: Comer AL; Department of Biology, Boston University, Boston, Massachusetts, United States of America.; The Graduate Program for Neuroscience, Boston University, Boston, Massachusetts, United States of America.; Neurophotonics Center, Boston University, Boston, Massachusetts, United States of America., Jinadasa T; Department of Biology, Boston University, Boston, Massachusetts, United States of America.; Neurophotonics Center, Boston University, Boston, Massachusetts, United States of America., Sriram B; Research and Early Development, Biogen, Cambridge, Massachusetts, United States of America., Phadke RA; Molecular Biology, Cell Biology and Biochemistry Program, Boston University, Boston, Massachusetts, United States of America., Kretsge LN; Department of Biology, Boston University, Boston, Massachusetts, United States of America.; The Graduate Program for Neuroscience, Boston University, Boston, Massachusetts, United States of America.; Neurophotonics Center, Boston University, Boston, Massachusetts, United States of America., Nguyen TPH; Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America., Antognetti G; Biologics Drug Discovery, Biogen, Cambridge, Massachusetts, United States of America., Gilbert JP; External Innovations and New Indications, Biogen, Cambridge, Massachusetts, United States of America., Lee J; Department of Biology, Boston University, Boston, Massachusetts, United States of America., Newmark ER; Department of Biology, Boston University, Boston, Massachusetts, United States of America., Hausmann FS; Department of Biology, Boston University, Boston, Massachusetts, United States of America., Rosenthal S; Department of Biology, Connecticut College, New London, Connecticut, United States of America., Liu Kot K; Department of Biology, Boston University, Boston, Massachusetts, United States of America., Liu Y; Biochemistry and Molecular Biology/Biotechnology Program, Boston University, Boston, Massachusetts, United States of America., Yen WW; Department of Biology, Boston University, Boston, Massachusetts, United States of America.; Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America., Dejanovic B; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America., Cruz-Martín A; Department of Biology, Boston University, Boston, Massachusetts, United States of America.; The Graduate Program for Neuroscience, Boston University, Boston, Massachusetts, United States of America.; Neurophotonics Center, Boston University, Boston, Massachusetts, United States of America.; Molecular Biology, Cell Biology and Biochemistry Program, Boston University, Boston, Massachusetts, United States of America.; Department Pharmacology and Experimental Therapeutics, Boston University, Boston, Massachusetts, United States of America.; Center for Systems Neuroscience, Boston University, Boston, Massachusetts, United States of America.

Publikováno v: PLoS biology [PLoS Biol] 2020 Jan 14; Vol. 18 (1), pp. e3000604. Date of Electronic Publication: 2020 Jan 14 (Print Publication: 2020).