Tacrine Induces Endoplasmic Reticulum-Stressed Apoptosis via Disrupting the Proper Assembly of Oligomeric Acetylcholinesterase in Cultured Neuronal Cells.

Autor: Liu EYL; Key Laboratory of Food Quality and Safety of Guangdong Province, College of Food Science, South China Agricultural University, Guangzhou, China (E.Y.L.L.); Institute of Pharmaceutical & Food Engineering, Chinese Medicine Master Studio of Wang Shimin, Shanxi University of Chinese Medicine, Jinzhong, China (X.K.); Shenzhen Key Laboratory of Edible and Medicinal Bioresources, SRI, The Hong Kong University of Science and Technology Shenzhen, China (S.M., X.K., Y.X., K.K.L.K., M.L.X., K.W.K.T.); and Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China (E.Y.L.L., S.M., Y.X., K.K.L.K., M.L.X., K.W.K.T.)., Mak S; Key Laboratory of Food Quality and Safety of Guangdong Province, College of Food Science, South China Agricultural University, Guangzhou, China (E.Y.L.L.); Institute of Pharmaceutical & Food Engineering, Chinese Medicine Master Studio of Wang Shimin, Shanxi University of Chinese Medicine, Jinzhong, China (X.K.); Shenzhen Key Laboratory of Edible and Medicinal Bioresources, SRI, The Hong Kong University of Science and Technology Shenzhen, China (S.M., X.K., Y.X., K.K.L.K., M.L.X., K.W.K.T.); and Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China (E.Y.L.L., S.M., Y.X., K.K.L.K., M.L.X., K.W.K.T.)., Kong X; Key Laboratory of Food Quality and Safety of Guangdong Province, College of Food Science, South China Agricultural University, Guangzhou, China (E.Y.L.L.); Institute of Pharmaceutical & Food Engineering, Chinese Medicine Master Studio of Wang Shimin, Shanxi University of Chinese Medicine, Jinzhong, China (X.K.); Shenzhen Key Laboratory of Edible and Medicinal Bioresources, SRI, The Hong Kong University of Science and Technology Shenzhen, China (S.M., X.K., Y.X., K.K.L.K., M.L.X., K.W.K.T.); and Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China (E.Y.L.L., S.M., Y.X., K.K.L.K., M.L.X., K.W.K.T.)., Xia Y; Key Laboratory of Food Quality and Safety of Guangdong Province, College of Food Science, South China Agricultural University, Guangzhou, China (E.Y.L.L.); Institute of Pharmaceutical & Food Engineering, Chinese Medicine Master Studio of Wang Shimin, Shanxi University of Chinese Medicine, Jinzhong, China (X.K.); Shenzhen Key Laboratory of Edible and Medicinal Bioresources, SRI, The Hong Kong University of Science and Technology Shenzhen, China (S.M., X.K., Y.X., K.K.L.K., M.L.X., K.W.K.T.); and Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China (E.Y.L.L., S.M., Y.X., K.K.L.K., M.L.X., K.W.K.T.)., Kwan KKL; Key Laboratory of Food Quality and Safety of Guangdong Province, College of Food Science, South China Agricultural University, Guangzhou, China (E.Y.L.L.); Institute of Pharmaceutical & Food Engineering, Chinese Medicine Master Studio of Wang Shimin, Shanxi University of Chinese Medicine, Jinzhong, China (X.K.); Shenzhen Key Laboratory of Edible and Medicinal Bioresources, SRI, The Hong Kong University of Science and Technology Shenzhen, China (S.M., X.K., Y.X., K.K.L.K., M.L.X., K.W.K.T.); and Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China (E.Y.L.L., S.M., Y.X., K.K.L.K., M.L.X., K.W.K.T.)., Xu ML; Key Laboratory of Food Quality and Safety of Guangdong Province, College of Food Science, South China Agricultural University, Guangzhou, China (E.Y.L.L.); Institute of Pharmaceutical & Food Engineering, Chinese Medicine Master Studio of Wang Shimin, Shanxi University of Chinese Medicine, Jinzhong, China (X.K.); Shenzhen Key Laboratory of Edible and Medicinal Bioresources, SRI, The Hong Kong University of Science and Technology Shenzhen, China (S.M., X.K., Y.X., K.K.L.K., M.L.X., K.W.K.T.); and Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China (E.Y.L.L., S.M., Y.X., K.K.L.K., M.L.X., K.W.K.T.)., Tsim KWK; Key Laboratory of Food Quality and Safety of Guangdong Province, College of Food Science, South China Agricultural University, Guangzhou, China (E.Y.L.L.); Institute of Pharmaceutical & Food Engineering, Chinese Medicine Master Studio of Wang Shimin, Shanxi University of Chinese Medicine, Jinzhong, China (X.K.); Shenzhen Key Laboratory of Edible and Medicinal Bioresources, SRI, The Hong Kong University of Science and Technology Shenzhen, China (S.M., X.K., Y.X., K.K.L.K., M.L.X., K.W.K.T.); and Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China (E.Y.L.L., S.M., Y.X., K.K.L.K., M.L.X., K.W.K.T.) botsim@ust.hk.

Publikováno v: Molecular pharmacology [Mol Pharmacol] 2021 Nov; Vol. 100 (5), pp. 456-469. Date of Electronic Publication: 2021 Sep 16.

Dehydrocorydaline Accounts the Majority of Anti-Inflammatory Property of Corydalis Rhizoma in Cultured Macrophage.

Autor: Kong X; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Hi-Tech Park, Shenzhen 518057, China.; Institute of Pharmaceutical and Food Engineering, Chinese Medicine Master Studio of Wang Shimin, Shanxi University of Chinese Medicine, 121 Daxue Road, Yuci District, Jinzhong 030619, China., Chen Z; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Hi-Tech Park, Shenzhen 518057, China.; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China., Xia Y; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Hi-Tech Park, Shenzhen 518057, China.; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China., Liu EYL; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Hi-Tech Park, Shenzhen 518057, China.; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China., Ren H; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Hi-Tech Park, Shenzhen 518057, China.; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China., Wang C; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Hi-Tech Park, Shenzhen 518057, China.; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China., Hu WWH; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Hi-Tech Park, Shenzhen 518057, China.; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China., Dong TTX; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Hi-Tech Park, Shenzhen 518057, China.; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China., Pi R; School of Medicine, Sun Yat-Sen University, Guangzhou 510006, China., Tsim KWK; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Hi-Tech Park, Shenzhen 518057, China.; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.

Publikováno v: Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2020 Nov 17; Vol. 2020, pp. 4181696. Date of Electronic Publication: 2020 Nov 17 (Print Publication: 2020).

Synergistic Inhibition of Acetylcholinesterase by Alkaloids Derived from Stephaniae Tetrandrae Radix, Coptidis Rhizoma and Phellodendri Chinensis Cortex.

Autor: Kong XP; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Hi-Tech Park, Shenzhen 518057, China.; Institute of Pharmaceutical & Food Engineering, Shanxi University of Chinese Medicine, 121 Daxue Road, Yuci District, Jinzhong 030619, China., Liu EYL; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Hi-Tech Park, Shenzhen 518057, China.; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China., Chen ZC; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Hi-Tech Park, Shenzhen 518057, China.; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China., Xu ML; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Hi-Tech Park, Shenzhen 518057, China.; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China., Yu AXD; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Hi-Tech Park, Shenzhen 518057, China.; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China., Wu QY; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Hi-Tech Park, Shenzhen 518057, China.; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China., Xia YJ; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Hi-Tech Park, Shenzhen 518057, China.; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China., Duan R; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Hi-Tech Park, Shenzhen 518057, China.; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China., Dong TTX; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Hi-Tech Park, Shenzhen 518057, China.; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China., Tsim KWK; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Hi-Tech Park, Shenzhen 518057, China.; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2019 Dec 13; Vol. 24 (24). Date of Electronic Publication: 2019 Dec 13.

Activation of G protein-coupled receptor 30 by flavonoids leads to expression of acetylcholinesterase in cultured PC12 cells.

Autor: Liu EYL; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, SRI, The Hong Kong University of Science and Technology Shenzhen, China; Division of Life Science, Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China., Xu ML; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, SRI, The Hong Kong University of Science and Technology Shenzhen, China; Division of Life Science, Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China., Xia Y; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, SRI, The Hong Kong University of Science and Technology Shenzhen, China; Division of Life Science, Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China., Kong X; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, SRI, The Hong Kong University of Science and Technology Shenzhen, China., Wu Q; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, SRI, The Hong Kong University of Science and Technology Shenzhen, China; Division of Life Science, Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China., Dong TTX; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, SRI, The Hong Kong University of Science and Technology Shenzhen, China; Division of Life Science, Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China., Tsim KWK; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, SRI, The Hong Kong University of Science and Technology Shenzhen, China; Division of Life Science, Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China. Electronic address: botsim@ust.hk.

Publikováno v: Chemico-biological interactions [Chem Biol Interact] 2019 Jun 01; Vol. 306, pp. 147-151. Date of Electronic Publication: 2019 Apr 26.

Erythropoietin regulates the expression of dimeric form of acetylcholinesterase during differentiation of erythroblast.

Autor: Xu ML; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China.; Shenzhen Key Laboratory of Edible and Medicinal Bioresourses, Shenzhen Research Institute, Shenzhen, China., Luk WKW; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China., Bi CWC; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China., Liu EYL; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China., Wu KQY; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China., Yao P; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China., Dong TTX; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China.; Shenzhen Key Laboratory of Edible and Medicinal Bioresourses, Shenzhen Research Institute, Shenzhen, China., Tsim KWK; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China.; Shenzhen Key Laboratory of Edible and Medicinal Bioresourses, Shenzhen Research Institute, Shenzhen, China.

Publikováno v: Journal of neurochemistry [J Neurochem] 2018 Aug; Vol. 146 (4), pp. 390-402. Date of Electronic Publication: 2018 Jul 23.