Fetal hypoplastic lungs have multilineage inflammation that is reversed by amniotic fluid stem cell extracellular vesicle treatment.

Autor: Antounians L; Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada.; Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto M5G 1X8, Canada., Figueira RL; Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada.; Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto M5G 1X8, Canada., Kukreja B; Neurosciences and Mental Health Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada., Litvack ML; Translational Medicine Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada., Zani-Ruttenstock E; Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada.; Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto M5G 1X8, Canada., Khalaj K; Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada.; Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto M5G 1X8, Canada., Montalva L; Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada.; Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto M5G 1X8, Canada., Doktor F; Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada.; Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto M5G 1X8, Canada., Obed M; Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada.; Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto M5G 1X8, Canada., Blundell M; Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada.; Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto M5G 1X8, Canada., Wu T; Neurosciences and Mental Health Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada., Chan C; Genetics and Genome Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto M5S 1A8, Canada., Wagner R; Department of Pediatric Surgery, Leipzig University, Leipzig 04109, Germany., Lacher M; Department of Pediatric Surgery, Leipzig University, Leipzig 04109, Germany., Wilson MD; Genetics and Genome Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto M5S 1A8, Canada., Post M; Translational Medicine Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada.; Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5T 1P5, Canada., Kalish BT; Neurosciences and Mental Health Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto M5S 1A8, Canada.; Division of Neonatology, The Hospital for Sick Children, Toronto M5G 1X8, Canada., Zani A; Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada.; Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto M5G 1X8, Canada.; Department of Surgery, University of Toronto, Toronto M5T 1P5, Canada.

Publikováno v: Science advances [Sci Adv] 2024 Jul 26; Vol. 10 (30), pp. eadn5405. Date of Electronic Publication: 2024 Jul 26.

Therapeutic stem cell-derived alveolar-like macrophages display bactericidal effects and resolve Pseudomonas aeruginosa-induced lung injury.

Autor: Bouch S; Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada., Litvack ML; Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada., Litman K; Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.; Laboratory Medicine and Pathobiology, The University of Toronto, Toronto, Ontario, Canada., Luo L; Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada., Post A; Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada., Williston E; Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada., Park AJ; Department of Molecular and Cellular Biology, The University of Guelph, Ontario, Canada., Roach EJ; Department of Molecular and Cellular Biology, The University of Guelph, Ontario, Canada., Berezuk AM; Department of Molecular and Cellular Biology, The University of Guelph, Ontario, Canada., Khursigara CM; Department of Molecular and Cellular Biology, The University of Guelph, Ontario, Canada., Post M; Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.; Laboratory Medicine and Pathobiology, The University of Toronto, Toronto, Ontario, Canada.

Publikováno v: Journal of cellular and molecular medicine [J Cell Mol Med] 2022 May; Vol. 26 (10), pp. 3046-3059. Date of Electronic Publication: 2022 Apr 20.

Embryonic-Derived Myb ^- Macrophages Enhance Bacterial Clearance and Improve Survival in Rat Sepsis.

Autor: Jerkic M; Keenan Research Centre for Biomedical Science, Unity Health Toronto St. Michael's, University of Toronto, Toronto, ON M5B 1T8, Canada., Litvack ML; Translational Medicine Program, Hospital for Sick Children, University of Toronto, Toronto, ON M5G 0A4, Canada., Gagnon S; Keenan Research Centre for Biomedical Science, Unity Health Toronto St. Michael's, University of Toronto, Toronto, ON M5B 1T8, Canada., Otulakowski G; Translational Medicine Program, Hospital for Sick Children, University of Toronto, Toronto, ON M5G 0A4, Canada., Zhang H; Keenan Research Centre for Biomedical Science, Unity Health Toronto St. Michael's, University of Toronto, Toronto, ON M5B 1T8, Canada., Rotstein O; Keenan Research Centre for Biomedical Science, Unity Health Toronto St. Michael's, University of Toronto, Toronto, ON M5B 1T8, Canada., Kavanagh BP; Translational Medicine Program, Hospital for Sick Children, University of Toronto, Toronto, ON M5G 0A4, Canada.; Department of Critical Care Medicine, Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada.; Departments of Anesthesia, Physiology and Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON M5S 1A1, Canada., Post M; Translational Medicine Program, Hospital for Sick Children, University of Toronto, Toronto, ON M5G 0A4, Canada.; Departments of Anesthesia, Physiology and Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON M5S 1A1, Canada., Laffey JG; Keenan Research Centre for Biomedical Science, Unity Health Toronto St. Michael's, University of Toronto, Toronto, ON M5B 1T8, Canada.; Departments of Anesthesia, Physiology and Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON M5S 1A1, Canada.; Department of Anesthesia and Critical Care Medicine, Unity Health Toronto St. Michael's, Toronto, ON M5B 1W8, Canada.; Regenerative Medicine Institute (REMEDI) at CÚRAM Centre for Research in Medical Devices, Biomedical Sciences Building, School of Medicine, National University of Ireland Galway, H91 TK33 Galway, Ireland.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2021 Mar 20; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 20.

A Single Sphingomyelin Species Promotes Exosomal Release of Endoglin into the Maternal Circulation in Preeclampsia.

Autor: Ermini L; Program in Translational Medicine, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada., Ausman J; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.; Institute of Medical Sciences, University of Toronto, Toronto, Ontario, M5S 1A8, Canada., Melland-Smith M; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada., Yeganeh B; Program in Translational Medicine, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada., Rolfo A; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada., Litvack ML; Program in Translational Medicine, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada., Todros T; Department of Obstetrics and Gynecology, University of Turin, Turin, 10126, Italy., Letarte M; Program in Molecular Medicine, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada.; Department of Immunology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada., Post M; Program in Translational Medicine, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada. martin.post@sickkids.ca.; Institute of Medical Sciences, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. martin.post@sickkids.ca.; Department of Physiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. martin.post@sickkids.ca.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. martin.post@sickkids.ca., Caniggia I; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.; Institute of Medical Sciences, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.; Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.

Publikováno v: Scientific reports [Sci Rep] 2017 Sep 22; Vol. 7 (1), pp. 12172. Date of Electronic Publication: 2017 Sep 22.

IFPA Meeting 2013 Workshop Report I: diabetes in pregnancy, maternal dyslipidemia in pregnancy, oxygen in placental development, stem cells and pregnancy pathology.

Autor: Abumaree MH; King Saud Bin Abdulaziz University for Health Sciences/King Abdullah International Medical Research Centre, Riyadh, Saudi Arabia., Alahari S; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada., Albrecht C; Institute of Biochemistry and Molecular Medicine and Swiss National Center of Competence in Research, NCCR-TransCure, University of Bern, Bern, Switzerland., Aye IL; Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, TX, USA., Bainbridge S; Interdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada., Chauvin S; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada., Clifton VL; Robinson Institute, Department of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia., Desoye G; Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria., Ermini L; Department of Physiology and Experimental Medicine, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada., Giuffrida D; Department of Surgical Sciences, University of Turin, Turin, Italy., Graham CH; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada., Huang QT; Division of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China., Kalionis B; Department of Perinatal Medicine, Pregnancy Research Centre and University of Melbourne, Department of Obstetrics and Gynaecology, Royal Women's Hospital, Parkville, Victoria, Australia., Lager S; Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, TX, USA., Leach L; School of Life Sciences, Faculty of Medicine, University of Nottingham, Nottingham, UK., Li Y; Department of Pathology, University of California San Diego, La Jolla, CA, USA., Litvack ML; Department of Physiology and Experimental Medicine, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada., Nuzzo AM; Department of Surgical Sciences, University of Turin, Turin, Italy., Moretto-Zita M; Sanford Consortium for Regenerative Medicine, Department of Pathology, University of California San Diego, La Jolla, CA, USA., O'Tierney-Ginn P; Centre for Reproductive Health, MetroHealth Medical Centre at Case Western Reserve University, Cleveland, OH, USA., Powell T; Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, TX, USA., Rolfo A; Department of Surgical Sciences, University of Turin, Turin, Italy., Salomon C; University of Queensland Centre for Clinical Research, Herston, Queensland, Australia., Serov A; Laboratoire PMC, CNRS - École Polytechnique, Palaiseau Cedex, France., Westwood M; Maternal and Fetal Health Research Centre, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK; St Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK., Yung HW; Centre for Trophoblast Research, University of Cambridge, Cambridge, UK., Lash GE; Reproductive and Vascular Biology Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK. Electronic address: gendie.lash@ncl.ac.uk.

Publikováno v: Placenta [Placenta] 2014 Feb; Vol. 35 Suppl, pp. S4-9. Date of Electronic Publication: 2013 Dec 01.